High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation

Abstract

The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat+ yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fed rats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.

Beneficial Effects of Newly Isolated Akkermansia muciniphila Strains from the Human Gut on Obesity and Metabolic Dysregulation

“…The number of blue-stained goblet cells and villus length in the HFD group were significantly lower than the normal group. This concurs with previous studies, where an HFD was accompanied by a distorted microvilli structure and disoriented crypts [ 70 ] as well as a significantly lower number of goblet cells [ 71 ]. In addition, the colonic gene expression of Muc2 was significantly suppressed in the animals after being fed an HFD.…”

Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

“…Likewise, collagens are highly upregulated in adipose tissue during metabolic challenges in the db/db mouse [28]. Currently, obese models of rats are being used to study fibrosis in other tissues, such as the pancreas (Zucker rats + high fat diet) [138] and liver (wistar rats + high fat diet) [139]; however, more research needs to focus on adipose tissue fibrosis in obese animal models.…”

Anti-Obesity Attributes; UHPLC-QTOF-MS/MS-Based Metabolite Profiling and Molecular Docking Insights of Taraxacum officinale

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