High fat diet disrupts diurnal interactions between small intestinal host innate immune factor REG3γ and gut microbiota resulting in metabolic dysfunction
Abstract:Background
Circadian rhythms are ubiquitous in nature, driving many bodily processes and behaviors, including sleep‐wake cycles and feeding patterns over 24 hours. We and others revealed gut microbes and their functional outputs also exhibit diurnal rhythms that are responsive to how much, what, and when food is consumed. These microbial cues are integrated into host circadian networks, serving as key regulators of metabolism. High fat (HF) diet disrupts diurnal microbial oscillations, impacting diet‐induced o… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.