High fat diet deteriorates the memory impairment induced by arsenic in mice: a sub chronic in vivo study

Alboghobeish, Soheila; Pashmforosh, Marzieh; Zeidooni, Leila; Samimi, Azin; Rezaeian, Mohsen

doi:10.1007/s11011-019-00467-4

Cited by 13 publications

(9 citation statements)

References 90 publications

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“…The increment is consistent in studies involving heavy metals intoxication [56,57,5], and might be due to arsenic-induced increased free radicals production [5]. Indeed, lipid peroxidation due to electron abstraction by free radicals is common during heavy metals toxicity [5,58,59]. Furthermore, excessive production of ROS due to impaired mitochondrial function has been reported during exposure to arsenic in drinking water [58].…”

Section: Discussionsupporting

confidence: 80%

“…Indeed, lipid peroxidation due to electron abstraction by free radicals is common during heavy metals toxicity [5,58,59]. Furthermore, excessive production of ROS due to impaired mitochondrial function has been reported during exposure to arsenic in drinking water [58]. The ROS so generated thus, caused elevation of MDA in the rat brain due to peroxidation of the mitochondrial membrane lipids.…”

Section: Discussionmentioning

confidence: 99%

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Flavonoid-rich fractions from Clerodendrum volubile and Vernonia amygdalina extenuates arsenic-invoked hepato-renal toxicity via augmentation of the antioxidant system in rats

Ugbaja

Akinhanmi

Ugwor

et al. 2021

Clinical Nutrition Open Science

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Arsenicosis remains a global health concern due to devastating health effects. Clerodendrum volubile and vernonia amygdalina have tremendous bioactivities against oxidative stress-related diseases. The study, therefore, appraised the effects of flavonoids fractions from C. volubile and V. amygdalina (FCV and FVA respectively) against arsenic-induced oxidative stress in rats. Thirty male Wistar rats (120 ± 10 g) were divided into six groups of five each; Control (distilled water), arsenic alone (40 ppm sodium arsenite), arsenic þ FCV (100 mg/kg), arsenic þ FVA (100 mg/kg), arsenic þ FCV and FVA (50 mg/kg each), and arsenic þ vitamin C (100 mg/kg). The treatment commenced after four-week long arsenic exposure and lasted another four weeks. Blood, liver and kidneys of the rats were collected after sacrifice following an overnight fast. Arsenic caused significant (p<0.05) reductions in the total thiols levels in the plasma, liver, and kidneys, as well as the lowering of catalase and glutathione peroxidase activities.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Flavonoid-rich fractions from Clerodendrum volubile and Vernonia amygdalina extenuates arsenic-invoked hepato-renal toxicity via augmentation of the antioxidant system in rats

Ugbaja

Akinhanmi

Ugwor

et al. 2021

Clinical Nutrition Open Science

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“…A low-fat diet in women is beneficial to cardiovascular health as shown by the Women's Health Initiative Dietary Modification Trial.23 However, a high-fat diet is associated with impaired memory. 24 We found that a highfat diet with exercise suppressed the depressive state compared with a high-fat diet without exercise and also induced hippocampal RCAN1 mRNA expression.…”

Section: Discussionmentioning

confidence: 66%

Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change inRCAN1expression

Wang

Nishijo

et al. 2020

J Int Med Res

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Objective Regulator of calcineurin 1 (RCAN1) controls plasticity of the nervous system and depressive conditions by regulating brain-derived neurotropic factor (BDNF) and plays a crucial role in neural and cardiac pathways. The apolipoprotein E gene ( ApoE) is a robust risk factor for progression of Alzheimer’s disease. A fatty diet is considered detrimental for metabolic disorders, such as obesity and cardiovascular diseases. Methods We examined the neuronal and cardiac protective roles of RCAN1 in ApoE−/− mice that were fed a high- or low-fat diet with and without voluntary movement for 3 months. Organ weights, laboratory data, histology, RNA expression, and behavior were examined. Results A high-fat diet with exercise improved depressive function, as examined by the forced swimming test, and RCAN1 mRNA expression was induced in the hippocampus. A low-fat diet with exercise resulted in a reduced body weight, higher heart weight/body weight ratio, and lower circulating triglyceride levels compared with a low-fat diet without exercise. RCAN1 mRNA expression was increased in cardiomyocytes in ApoE−/− mice. Conclusions The combination of a high-fat diet and exercise might reduce depressive function, whereas a low-fat diet with exercise leads to cardioprotection. Induction of RCAN1 expression might affect neuroplasticity and cardiac function.

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“…In order to confirm whether changes in mechanical pain threshold are T cell‐dependent, we selected 20 healthy SPF male BALB/c mice and 20 BALB/c‐nu mice (athymic nude mice, weighing 18 ± 2 g) to repeat As treatment for 10 weeks. After acclimatizing, mice and nude mice were randomly divided into control group (distilled water) and As‐treated group with concentration of 50 ppm, which was chosen in the light of a combination effect study on high‐fat diet and As exposure in mice model 37 . Each groups contained 10 mice.…”

Section: Methodsmentioning

confidence: 99%

“…After acclimatizing, mice and nude mice were randomly divided into control group (distilled water) and As-treated group with concentration of 50 ppm, which was chosen in the light of a combination effect study on high-fat diet and As exposure in mice model. 37 Each groups contained 10 mice. All experiments were carried out under protocols approved by Animal Ethics Committee of Xiangya School of Public Health, Central South University.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

MBP‐activated autoimmunity plays a role in arsenic‐induced peripheral neuropathy and the potential protective effect of mecobalamin

Chen

et al. 2021

Environmental Toxicology

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Intake excessive arsenic (As) is related to the occurrence of peripheral neuropathy.However, both the underlying mechanism and the preventive approach remain largely unknown. In the present study, As treatment significantly decreased the mechanical withdrawal threshold and increased the titer of anti-myelin basic protein antibody in rats, accompanied with damaged BNB. The levels of inflammatory cytokines and proteolytic enzymes were also significantly upregulated. However, administration of MeCbl in As-treated rats significantly reversed the decline in hindfoot mechanical withdrawal threshold, as well as BNB failure and sciatic nerve inflammation. Repeated As treatment in athymic nude mice indicated that sciatic nerve inflammation and mechanical hyperalgesia were T cell-dependent. These data implicated that MBP-activated autoimmunity and the related neuroinflammation probably contributed to As-induced mechanical hyperalgesia and MeCbl exerted a protective role probably via maintenance the integrity of BNB and inhibition of neuroinflammation.

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High fat diet deteriorates the memory impairment induced by arsenic in mice: a sub chronic in vivo study

Cited by 13 publications

References 90 publications

Flavonoid-rich fractions from Clerodendrum volubile and Vernonia amygdalina extenuates arsenic-invoked hepato-renal toxicity via augmentation of the antioxidant system in rats

Flavonoid-rich fractions from Clerodendrum volubile and Vernonia amygdalina extenuates arsenic-invoked hepato-renal toxicity via augmentation of the antioxidant system in rats

Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change inRCAN1expression

MBP‐activated autoimmunity plays a role in arsenic‐induced peripheral neuropathy and the potential protective effect of mecobalamin

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