High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain

Sharma, Saurabh

doi:10.1016/j.physbeh.2021.113528

Cited by 31 publications

(19 citation statements)

References 236 publications

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“…Lipids play an important role in neuronal membrane composition and function. HFD alters the neuronal and vascular components of the brain (Sharma 2021 ). In the current study, Res treatment nearly normalized different lipid profile parameters of the treated group, where treated rats showed decreased total serum cholesterol and serum TG, and increased HDL in comparison to diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action

et al. 2022

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Cognitive impairment is considered as a typical feature of neurodegenerative diseases in diabetes mellitus (DM). However, the exact link between cognitive dysfunction and diabetes mellitus is still vague. This study aims to investigate some of the mechanisms underlying cognitive impairment that associates diabetes mellitus and insulin resistance. We investigated the role of resveratrol as well on cognitive function in experimentally induced type 2 diabetes highlighting on its influence on the expression of brain miRNA 21. Resveratrol is a naturally occurring, biologically active compound that has numerous significant impacts on the body. Type 2 diabetes mellitus was induced by high fat diet followed a single dose of streptozotocin. Diabetic rats were treated with resveratrol for four weeks. Rats were sacrificed after neurobehavioral testing. Hippocampal tissues were used to assess expression of miRNA 21, GSK and oxidative stress markers. Serum samples were obtained to determine glucose levels, lipid profile and insulin levels. Hippocampal and serum AGEs were measured as well and HOMA IR was calculated. We detected memory impairment and disturbed insulin signaling in diabetic rats. These derangements were reversed by resveratrol treatment partially due to increased expression of miRNA-21. Our study pins the role of miRNA-21 in modulating brain insulin signaling and hence alleviating cognitive dysfunction accompanying diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action

et al. 2022

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“…Moreover, A 2A R deserves special attention in numerous neurological disorders since its pharmacological inhibition prevents memory deficits [17,20,[64][65][66]. Intake of HFD is associated with cognitive dysfunction, as recently reviewed in rodents [67], and recapitulates some AD-like features in mice [68]. In the present study, we found increased A 2A R levels in HFD fed C57BL/6J mice, a diet that also induces hippocampal-dependent memory deficits in C57BL/6J mice treated since their weaning until 6 months of age [69] and favors the formation of βA depositions in the DG area of the hippocampus when treated since their weaning until 16 months of age [70].…”

Section: Discussionmentioning

confidence: 99%

High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice

et al. 2021

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Neurodegenerative disorders are devastating diseases in which aging is a major risk factor. High-fat diet (HFD) seems to contribute to cognition deterioration, but the underlying mechanisms are poorly understood. Moreover, resveratrol (RSV) has been reported to counteract the loss of cognition associated with age. Our study aimed to investigate whether the adeno-synergic system and plasma membrane cholesterol are modulated by HFD and RSV in the cerebral cortex of C57BL/6J and SAMP8 mice. Results show that HFD induced increased A1R and A2AR densities in C57BL/6J, whereas this remained unchanged in SAMP8. Higher activity of 5′-Nucleotidase was found as a common effect induced by HFD in both mice strains. Furthermore, the effect of HFD and RSV on A2BR density was different depending on the mouse strain. RSV did not clearly counteract the HFD-induced effects on the adeno-synergic system. Besides, no changes in free-cholesterol levels were detected in the plasma membrane of cerebral cortex in both strains. Taken together, our data suggest a different modulation of adenosine receptors depending on the mouse strain, not related to changes in plasma membrane cholesterol content.

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“…Among the factors that lead to the development of neurodegenerative processes and cognitive deficit in T2DM and MS, the most important are cerebrovascular dysfunctions [ 256 , 257 ], reduced glucose metabolism in brain structures [ 258 ], neuroinflammation [ 259 , 260 , 261 , 262 , 263 ], as well as central IR, which is also observed in patients with AD [ 258 , 262 , 264 ]. Impaired insulin signaling may affect only certain areas of the brain, which is due to region-specific changes in the expression, distribution, and activity of INSR and downstream components of the insulin signaling system [ 37 , 265 , 266 , 267 ].…”

Section: Intranasal Insulin and Diabetes Mellitusmentioning

confidence: 99%

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

Zorina

Derkach

2023

IJMS

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A decrease in the activity of the insulin signaling system of the brain, due to both central insulin resistance and insulin deficiency, leads to neurodegeneration and impaired regulation of appetite, metabolism, endocrine functions. This is due to the neuroprotective properties of brain insulin and its leading role in maintaining glucose homeostasis in the brain, as well as in the regulation of the brain signaling network responsible for the functioning of the nervous, endocrine, and other systems. One of the approaches to restore the activity of the insulin system of the brain is the use of intranasally administered insulin (INI). Currently, INI is being considered as a promising drug to treat Alzheimer’s disease and mild cognitive impairment. The clinical application of INI is being developed for the treatment of other neurodegenerative diseases and improve cognitive abilities in stress, overwork, and depression. At the same time, much attention has recently been paid to the prospects of using INI for the treatment of cerebral ischemia, traumatic brain injuries, and postoperative delirium (after anesthesia), as well as diabetes mellitus and its complications, including dysfunctions in the gonadal and thyroid axes. This review is devoted to the prospects and current trends in the use of INI for the treatment of these diseases, which, although differing in etiology and pathogenesis, are characterized by impaired insulin signaling in the brain.

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High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain

Cited by 31 publications

References 236 publications

Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action

Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action

High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice

Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium

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