High expression of UBE2T predicts poor prognosis and survival in multiple myeloma

Zhang, Weilong; Zhang, Ye; Yang, Zuozhen; Liu, Xiaoni; Yang, Ping; Wang, Jing; Hu, Kai; He, Xue; Zhang, Xiuru; Jing, Hongmei

doi:10.1038/s41417-018-0070-x

Cited by 34 publications

(30 citation statements)

References 40 publications

(41 reference statements)

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“…Therefore, UBE2T may be considered as a potential drug target for patients with gallbladder cancer. Numerous studies demonstrated that UBE2T is overexpressed in various types of cancer, including multiple myeloma ( 20 ), hepatocellular carcinoma ( 54 ), bladder cancer ( 24 ) and osteosarcoma ( 25 ), suggesting that it may be an attractive drug target. The results from the present study indicated that UBE2T may be considered as a prognostic factor for patients with gallbladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Among all hub genes identified, ubiquitin conjugating enzyme E2T (UBE2T) was firstly highlighted in a patient with Fanconi anemia (18). It has been reported that hypoxia may disrupt the Fanconi anemia pathway and sensitize tumor cells to chemotherapy by regulating UBE2T (19,20). Furthermore, UBE2T overexpression is associated with poor prognosis of patients with various types of cancer, including breast cancer and multiple myeloma (21,22).…”

Section: Introductionmentioning

confidence: 99%

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Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer

Zhu

Li²,

Niu

et al. 2020

Oncol Lett

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Gallbladder cancer is the most common biliary tract malignant tumor, with unfavorable patient outcomes. The present study aimed to identify potential diagnostic or prognostic biomarkers for gallbladder cancer. To do so, differentially expressed genes in the gallbladder walls and tumor tissues of patients with gallbladder cancer were analyzed via microarray. Furthermore, a protein-protein interaction network was constructed and genes with a degree score >10 were selected as hub genes. As ubiquitin conjugating enzyme E2T (UBE2T) was considered to be a hub gene, its expression was assessed via reverse transcription-quantitative (RT-q)PCR and immunohistochemistry (IHC). In addition, the association between UBE2T expression and the clinicopathological characteristics of patients with gallbladder cancer was analyzed using the χ 2 test. Furthermore, all patients were divided into high-and low groups based on UBE2T expression level and overall survival analysis was performed. Univariate and multivariate Cox regression analyses were performed to determine whether UBE2T may serve as an independent risk factor for gallbladder cancer. The results demonstrated that UBE2T expression was upregulated in the gallbladder walls and tumor tissues of patients with gallbladder cancer. Furthermore, UBE2T expression level was confirmed to be upregulated following RT-qPCR, and results from IHC demonstrated that UBE2T was predominantly expressed in the cytoplasm of gallbladder cancer cells. In addition, high UBE2T expression level was associated with clinical stage, T classification, N classification and M classification. The results from Univariate and multivariate analyses indicated that UBE2T expression level may be considered as an independent risk factor for gallbladder cancer. Taken together, the findings from this study suggested that high UBE2T expression level may contribute to the poor prognosis of patients with gallbladder cancer, and that UBE2T may act as an independent prognostic biomarker for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer

Zhu

Li²,

Niu

et al. 2020

Oncol Lett

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“…For example, UBE2T is remarkably upregulated in MM cells, especially in the early stage. UBE2T level is signi cantly associated with IgG serotype of MM and UBE2T upregulation predicts poor prognosis, including OS and event-free survival time, of patients with MM [29]. Furthermore, UBE2T is upregulated in gastric cancer tissues and cells, positively associated with poor differentiation, advanced T stage, and short OS time in patients with gastric cancer [9,10].…”

Section: Discussionmentioning

confidence: 98%

UBE2T is upregulated, predicts poor prognosis, and promotes cell proliferation and invasion via inhibiting autophagy in ovarian cancer

Huang

Xiao

et al. 2020

Preprint

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Background: Aberrant upregulation and oncogenic roles of UBE2T have been revealed in several cancers. However, the expression, clinical significance, and functions of UBE2T has not been explored in ovarian cancer (OC).Methods: In this study, the mRNA and protein expression of UBE2T in OC were detected via analyzing the online databases and immunohistochemical staining. Moreover, relations of UBE2T expression with clincopathological features and prognosis OC patients were further analyzed. Besides, the effects of UBE2T knockdown on growth, proliferation, and invasion of OC cells were investigated by CCK-8, plate clone formation, and Transwell assays. Finally, the underlying mechanism of UBE2T associated functions in OC was analyzed.Results: The results indicated that UBE2T was significantly upregulated in OC tissues. UBE2T expression was notably correlated with clinical features such as primary T stage, TNM stage in OC patients. UBE2T, acting as an independent prognostic indicator, was inversely associated with prognosis of OC patients. UBE2T knockdown remarkably suppressed the growth, proliferation, and invasion of OC cells indicating by impaired cell viability, less cell clones and invasive cells. Mechanistically, the oncogenic roles of UBE2T was exerted by inhibiting autophagy via maintaining AKT/mTOR activity in OC.Conclusion: Collectively, our findings confirm UBE2T upregulation predicts poor prognosis and promotes malignant progression via suppressing autophagy in OC, suggesting the promising values of UBE2T both in diagnosis and treatment of OC.

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“…In addition to DNA crosslinkers, the FA pathway also confers resistance to DNA alkylating agents in glioma [110]. Alongside FA-mediated drug resistance are observations that FANCA and FANCT/UBE2T correlate with poor prognosis and survival of cancer patients [111,112]. These pre-clinical data highlight the need for development of FA targeted drugs in circumstances where chemotherapy resistance emerges as a result of elevated FA pathway expression and function.…”

Section: Association Of the Fa Pathway With Drug Resistancementioning

confidence: 99%

Fanconi anemia pathway as a prospective target for cancer intervention

Liu

Palovcak

et al. 2020

Cell Biosci

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Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a genetic vulnerability for cancer predisposition. The cancer relevance of the FA pathway is further established with the pervasive occurrence of FA gene alterations in somatic cancers and observations of FA pathway activation-associated chemotherapy resistance. In this article we describe the role of the FA pathway in canonical interstrand crosslink (ICL) repair and possible contributions of FA gene alterations to cancer development. We also discuss the perspectives and potential of targeting the FA pathway for cancer intervention.

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High expression of UBE2T predicts poor prognosis and survival in multiple myeloma

Cited by 34 publications

References 40 publications

Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer

Identification of UBE2T as an independent prognostic biomarker for gallbladder cancer

UBE2T is upregulated, predicts poor prognosis, and promotes cell proliferation and invasion via inhibiting autophagy in ovarian cancer

Fanconi anemia pathway as a prospective target for cancer intervention

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