High Expression of TTYH3 is Related to Poor Clinical Outcomes in Human Gastric Cancer

Saha, Subbroto Kumar; Biswas, Polash Kumar; Gil, Minchan; Cho, Ssang-Goo

doi:10.3390/jcm8111762

Cited by 24 publications

(18 citation statements)

References 65 publications

(81 reference statements)

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“…42,43 A study revealed that the upregulation of the TTYH3 in gastric cancer was associated with shorter survival. 44 Nevertheless, little is known about the expression and function of TTYH3 in any other tumors. Our data revealed a potentially important role for TTYH3 in the development of HPV-negative cervical cancer, because higher expression of TTYH3 was observed in HPV-negative cervical cancer cells and tissues.…”

Section: Discussionmentioning

confidence: 99%

Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer

Liu

Jiang

et al. 2021

Molecular Therapy - Methods & Clinical Development

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Cervical cancer is a common female malignancy that is mainly caused by human papillomavirus (HPV) infection. However, the incidence of HPV-negative cervical cancer has shown an increasing trend in recent years. Because the mechanism of HPV-negative cervical cancer development is unclear, this study aims to find the pattern of differential gene expression in HPV-negative cervical cancer and verify the underlying potential mechanism. Differentially expressed genes were compared among HPV-positive cervical cancer, HPV-negative cervical cancer, and normal cervical tissues retrieved from TCGA. Subsequently, dysregulated differentially expressed genes specifically existed in HPV-negative cervical cancer tissues and HPV-negative cell lines were validated by qRT-PCR, western blotting, and immunohistochemical staining. We found seventeen highly expressed genes that were particularly associated with HPV-negative cervical cancer from analysis of TCGA database. Among the 17 novel genes, 7 genes (preferentially expressed antigen in melanoma [PRAME], HMGA2, ETS variant 4 [ETV4], MEX3A, TM7SF2, SLC19A1, and tweety-homologs 3 [TTYH3]) displayed significantly elevated expression in HPV-negative cervical cancer cells and HPV-negative cervical cancer tissues. Additionally, higher expression of MEX3A and TTYH3 was associated with a shorter overall survival of patients with HPV-negative cervical cancer. Our study implies that these seven genes are more likely to provide novel insights into the occurrence and progression of HPV-negative cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer

Liu

Jiang

et al. 2021

Molecular Therapy - Methods & Clinical Development

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“…In addition to central nervous system-associated cancers and colon cancers, tweety is implicated in other cancers including breast, clear cell sarcoma, gastric, histiocytic sarcoma, kidney, osteosarcoma, and thyroid cancers. Expression from immunohistochemistry images and clinical outcome data in patients with gastric cancer analyzed using various databases (e.g., Human Protein Atlas, Oncomine, UALCAN, and Gene Expression Omnibus) revealed upregulated TTYH3 in gastric cancer compared to normal tissue (Rhodes et al, 2004 ; Saha et al, 2019 7 ). Furthermore, Kaplan-Meier analysis (modeling patient survival probability over time) demonstrated a correlation between TTYH3 upregulation and decreased patient survival (Saha et al, 2019 ).…”

Section: The Role Of Tweety Genes In Diseasementioning

confidence: 99%

“…Expression from immunohistochemistry images and clinical outcome data in patients with gastric cancer analyzed using various databases (e.g., Human Protein Atlas, Oncomine, UALCAN, and Gene Expression Omnibus) revealed upregulated TTYH3 in gastric cancer compared to normal tissue (Rhodes et al, 2004 ; Saha et al, 2019 7 ). Furthermore, Kaplan-Meier analysis (modeling patient survival probability over time) demonstrated a correlation between TTYH3 upregulation and decreased patient survival (Saha et al, 2019 ). These findings suggest TTYH3 facilitates gastric cancer pathology.…”

Section: The Role Of Tweety Genes In Diseasementioning

confidence: 99%

The tweety Gene Family: From Embryo to Disease

Nalamalapu

Yue

Stone

et al. 2021

Front. Mol. Neurosci.

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The tweety genes encode gated chloride channels that are found in animals, plants, and even simple eukaryotes, signifying their deep evolutionary origin. In vertebrates, the tweety gene family is highly conserved and consists of three members—ttyh1, ttyh2, and ttyh3—that are important for the regulation of cell volume. While research has elucidated potential physiological functions of ttyh1 in neural stem cell maintenance, proliferation, and filopodia formation during neural development, the roles of ttyh2 and ttyh3 are less characterized, though their expression patterns during embryonic and fetal development suggest potential roles in the development of a wide range of tissues including a role in the immune system in response to pathogen-associated molecules. Additionally, members of the tweety gene family have been implicated in various pathologies including cancers, particularly pediatric brain tumors, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Here, we review the current state of research using information from published articles and open-source databases on the tweety gene family with regard to its structure, evolution, expression during development and adulthood, biochemical and cellular functions, and role in human disease. We also identify promising areas for further research to advance our understanding of this important, yet still understudied, family of genes.

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“…Oncomine database 1 , a cancer microarray database and webbased data mining platform (Saha et al, 2019), was used to analyze the expression level of the SPP1 gene in various types of cancers. The threshold was set as 0.001 for P value, 1.5 for fold change (FC), and gene ranking of all.…”

Section: Oncomine Database Analysismentioning

confidence: 99%

The Significance of Secreted Phosphoprotein 1 in Multiple Human Cancers

Wei

Bian

et al. 2020

Front. Mol. Biosci.

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Malignant tumor represents a major reason for death in the world and its incidence is growing rapidly. Developing the tools for early diagnosis is possibly a promising way to offer diverse therapeutic options and promote the survival chance. Secreted phosphoprotein 1 (SPP1), also called Osteopontin (OPN), has been demonstrated overexpressed in many cancers. However, the specific role of SPP1 in prognosis, gene mutations, and changes in gene and miRNA expression in human cancers is unclear. In this report, we found SPP1 expression was higher in most of the human cancers. Based on Kaplan-Meier plotter and the PrognoScan database, we found high SPP1 expression was significantly correlated with poor survival in various cancers. Using a large dataset of colon adenocarcinoma (COAD), head and neck cancer (HNSC), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC) patients from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases, this study identified 22 common genes and 2 common miRNAs. GO, and KEGG paths analyses suggested that SPP1 correlated genes were mainly involved in positive regulation of immune cell activation and infiltration. SPP1-associated genes and miRNAs regulatory networks suggested that their interactions may play a role in the progression of four selected cancers. SPP1 showed significant positive correlation with the immunocyte and immune marker sets infiltrating degrees. All of these data provide strong evidence that SPP1 may promote tumor progress through interacting with carcinogenic genes and facilitating immune cells’ infiltration in COAD, HNSC, LUAD, and LUSC.

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High Expression of TTYH3 is Related to Poor Clinical Outcomes in Human Gastric Cancer

Cited by 24 publications

References 65 publications

Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer

Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer

The tweety Gene Family: From Embryo to Disease

The Significance of Secreted Phosphoprotein 1 in Multiple Human Cancers

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