High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma

Zhu, Xinghua; Wu, Yong; Miao, Xiaobing; Li, Chunsun; Yin, Haibing; Yang, Shuyun; Lu, Xiaoyun; Liu, Yushan; Chen, Yali; Shen, Rong; Chen, Xudong; He, Song

doi:10.1007/s13277-016-5316-3

Cited by 43 publications

(60 citation statements)

References 32 publications

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“…Published studies have also reported that increased TRIM44 expression promoted cell migration and invasion in NSCLC and hepatocellular carcinoma by regulating key components of EMT . We therefore investigated whether TRIM44 similarly mediated EMT to promote cell migration and invasion in HEC cell lines.…”

Section: Resultsmentioning

confidence: 94%

“…TRIM44 overexpression facilitates cell proliferation, migration, and invasion in gastric cancer, hepatocellular carcinoma, testicular germ cell tumors, and non‐small cell lung cancer (NSCLC) . In addition, knocking down endogenous TRIM44 expression inhibits proliferation and motility in cancer cells . Moreover, TRIM44 has been identified as an independent prognostic marker in patients with different types of cancer .…”

Section: Introductionmentioning

confidence: 99%

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TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway

Xiong

Chun

et al. 2018

Cancer Science

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Aberrant expression of TRIM‐containing protein 44 (TRIM44) acts as a promoter in multiple cancers. Here, we investigated the biological functions and clinical significance of TRIM44 in human esophageal cancer (HEC). TRIM44 expression was significantly higher in HEC tissues than corresponding normal tissues at both the mRNA (2.42 ± 0.52 vs 0.99 ± 0.25) and protein (1.01 ± 0.27 vs 0.30 ± 0.13) levels. Patients with high TRIM44 expression showed poor differentiation (P = 1.39 × 10−5), advanced TNM stage (P = 3.87 × 10−4) and, most importantly, significantly poorer prognosis (P = 2.80 × 10−5). TRIM44 played a crucial role in epithelial mesenchymal transition (EMT). A significant correlation was observed between TRIM44 and Ki67 expression. We demonstrated that TRIM44 markedly enhanced HEC cell proliferation, migration, and invasion. Additionally, TRIM44 was involved in the AKT/mTOR signaling pathway and its downstream targets, such as STAT3 phosphorylation. Thus, elevated TRIM44 expression promotes HEC development by EMT via the AKT/mTOR pathway, and TRIM44 may be a novel prognostic indicator for HEC patients after curative resection.

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Section: Resultsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway

Xiong

Chun

et al. 2018

Cancer Science

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“…A previous study indicated that a high expression of TRIM44 was associated with poor prognosis and that TRIM44 may be involved in cell proliferation, migration, and anti-apoptotic effects in testicular germ cell tumors (7). Zhu et al (4) demonstrated that the overexpression of TRIM44 enhanced the invasive and migratory capacities of hepatocellular carcinoma cells. Kashimoto et al (5) suggested that TRIM44 may be crucial in tumor cell proliferation through its overexpression, and indicated its usefulness as a predictor and potential therapeutic target in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have suggested that TRIM44 may have an oncogenic role in the invasion and metastases of several types of human cancer, including prostate cancer (3), hepatocellular carcinoma (4), gastric carcinoma (5), non-small cell lung cancer (6) and testicular germ cell tumors (7). However, at present, the precise function of TRIM44 and its underlying carcinogenic mechanism in ovarian cancer remain to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

Liu

Yin

et al. 2018

Exp Ther Med

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Tripartite motif-containing 44 (TRIM44) has been demonstrated to be important in tumor metastasis and progression. However, the expression pattern and prognostic value of the expression of TRIM44 in epithelial ovarian cancer (EOC) remain to be fully elucidated. In the present study, the aim was to investigate the expression and clinical role of TRIM44 in EOC. A total of 109 patients, who underwent primary surgery with the goal of maximal tumor resection followed by standard combination chemotherapy with carboplatin and paclitaxel, were analyzed in the present study. The expression level of TRIM44 was determined by western blot analysis and immunohistochemistry in 109 ECO tissues. It was found that the expression of TRIM44 was low in normal tissues and high in EOC tissues. Univariate survival analysis showed that the overexpression of TRIM44 was significantly associated with International Federation of Gynecology and Obstetrics stage and lymph node metastasis (P<0.05). Kaplan-Meier analysis suggested that there was a significant difference in overall survival and disease-free survival rates between patients with a high expression of TRIM44 and patients with a low expression of TRIM44. Patients with a high expression level of TRIM44 exhibited poorer overall survival and disease-free survival rates, compared with patients expressing a low level of TRIM44 (P<0.001). In addition, the results of the multivariate analysis revealed that the predictive value of the expression of TRIM44 was independent of other clinicopathological factors for predicting prognosis. These findings demonstrated that a high expression of TRIM44 was associated with the progression and prognosis of EOC.

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“…Palmbos et al reported that TRIM29 overexpression in invasive bladder cancer was associated with poor prognosis (Palmbos et al, 2015). In HCC, the expression of several TRIM proteins, such as TRIM44 and TRIM26, was able to predict the overall survival of patients Zhu et al, 2016). The upregulation of TIMR65 in lung cancer was reported to be correlated with unfavorable outcome (Wang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

TRIM65 triggers β-Catenin signaling via ubiquitination of Axin1 to promote hepatocellular carcinoma

Yang

Zhang

Qing

et al. 2017

Journal of Cell Science

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Deregulation of ubiquitin ligases contributes to the malignant progression of human cancers. Tripartite motif-containing protein 65 (TRIM65) is an E3 ubiquitin ligase and has been implicated in human diseases, but its role and clinical significance in hepatocellular carcinoma (HCC) remain unknown. Here, we showed that TRIM65 expression was increased in HCC tissues and associated with poor outcome in two independent cohorts containing 888 patients. In vitro and in vivo data demonstrated that overexpression of TRIM65 promoted cell growth and tumor metastasis, whereas knockdown of TRIM65 resulted in opposite phenotypes. Further studies revealed that TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the β-catenin signaling pathway. TRIM65 directly bound to Axin1 and accelerated its degradation through ubiquitylation. Furthermore, HMGA1 was identified as an upstream regulator of TRIM65 in HCC cells. In clinical samples, TRIM65 expression was positively correlated with the expression of HMGA1 and nuclear β-catenin. Collectively, our data indicate that TRIM65 functions as an oncogene in HCC. The newly identified HMGA1/TRIM65/β-catenin axis serves as a promising prognostic factor and therapeutic target.

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High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma

Cited by 43 publications

References 32 publications

TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway

TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway

Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

TRIM65 triggers β-Catenin signaling via ubiquitination of Axin1 to promote hepatocellular carcinoma

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