High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma

Abstract

High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein expression is associated with the prognosis of stage IIIB cervical carcinoma. Methods: sixty-three patients with stage IIIB squamous cell cervical carcinoma were included. The evaluation of SOD2 expression by immunohistochemistry was based on a positive cell ratio score and the staining intensity score. Taking disease recurrence and death as endpoints, receiver operating characteristic curves were used to discriminate between high and low SOD2 expression. Results: high SOD2 expression was associated with recurrence (p = 0.001), distant recurrence (p = 0.002), and death (p = 0.005). A multivariate analysis showed that patients with high SOD2 expression had a threefold increased risk for recurrence (HR = 3.16; 1.33–7.51) and death (HR = 2.98; 1.20–7.40) compared with patients who had low SOD2 expression. Patients with high SOD2 expression had shorter disease-free survival (p = 0.001) and overall survival (p = 0.003) than patients with low SOD2 expression. Conclusion: high SOD2 expression is a strong prognostic factor for stage IIIB squamous cell carcinoma of the cervix and could be used as a prognostic marker in women with cervical carcinoma.

Extracellular Vesicles Derived from Neutrophils Accelerate Bone Regeneration by Promoting Osteogenic Differentiation of BMSCs

“…Although the enrichment of key pathways that direct osteogenic differentiation was not observed, SOD2 and GJA1 were identified as proteins with significant differences in expression between BMSCs treated with PMN-EVs versus PBS; these have been reported as key osteogenic proteins with notable expression in BMSCs during osteogenic induction. − The upregulation of SOD2 and GJA1 proteins was verified by Western blot analysis (Figure f and g), suggesting that PMN-EVs potentially promote osteogenic differentiation by increasing the expression of SOD2 and GJA1. Furthermore, SOD2 is the principal antioxidant enzyme found in mitochondria and contributes to the protection of cells from ROS-induced oxidative damage; it is therefore essential for the survival of aerobic organisms , and interacts with several important proteins, including GJA1 (Figure h). Thus, the effect of PMN-EVs treatment on the protection of BMSCs against oxidative damage was assessed; the treatment with PMN-EVs were found to significantly limit the ROS activity in BMSCs irrespective of the addition of H 2 O 2 (Figure i), indicating that PMN-EVs not only promote the osteogenic differentiation of BMSCs but also afford protection from ROS-induced oxidative damage by increasing SOD2 expression.…”

Propofol modulates glycolysis reprogramming of ovarian tumor via restraining circular RNA-zinc finger RNA-binding protein/microRNA-212-5p/superoxide dismutase 2 axis

“…Antioxidant SOD2, a conserved antioxidant enzyme, is available to remove mitochondria-produced reactive oxygen species and exerts a critical role in maintaining cell homeostasis [ 30 ]. Elevated SOD2 is associated with unpleasing prognosis, metastasis, and malignant progression of diversified cancers [ 31 ]. Several foregoing researches have illuminated SOD2 as augmented by epithelial ovarian cancer (EOC) tissues and cells, accelerating EOC cell advancement with chemical sensitivity [ 32 ].…”

Combined Transcriptomic and Proteomic Profiling to Unravel Osimertinib, CARP-1 Functional Mimetic (CFM 4.17) Formulation and Telmisartan Combo Treatment in NSCLC Tumor Xenografts

“…High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cancer [48].…”