2016
DOI: 10.1038/bcj.2015.107
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High expression of PTPN21 in B-cell non-Hodgkin’s gastric lymphoma, a positive mediator of STAT5 activity

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Cited by 12 publications
(11 citation statements)
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“…PTPN14 is a well-known tumor suppressor, and our previous study demonstrated that E7 binding-defective mutations remarkably enhance the ability of PTPN14 to delay HeLa cell proliferation, migration, and invasion ( Yun et al, 2019 ). On the other hand, the physiological function of PTPN21 in cervical cancer development is not yet clearly understood, although PTPN21 was reported to be upregulated in several particular cancer types, such as B-cell non-Hodgkin’s gastric lymphoma and bladder cancer ( Carlucci et al, 2010 ; Plani-Lam et al, 2016 ). Unlike PTPN14, PTPN21 exhibited a proteasomal degradation-evasive character, and E7-binding capability did not notably affect its protein level ( Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…PTPN14 is a well-known tumor suppressor, and our previous study demonstrated that E7 binding-defective mutations remarkably enhance the ability of PTPN14 to delay HeLa cell proliferation, migration, and invasion ( Yun et al, 2019 ). On the other hand, the physiological function of PTPN21 in cervical cancer development is not yet clearly understood, although PTPN21 was reported to be upregulated in several particular cancer types, such as B-cell non-Hodgkin’s gastric lymphoma and bladder cancer ( Carlucci et al, 2010 ; Plani-Lam et al, 2016 ). Unlike PTPN14, PTPN21 exhibited a proteasomal degradation-evasive character, and E7-binding capability did not notably affect its protein level ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Our previous study also revealed that PTPN21 or PTPD1 can directly interact with CR3 of HPV18 E7 ( Yun et al, 2019 ), consistent with previous systematic proteomic analyses ( Rozenblatt-Rosen et al, 2012 ; White et al, 2012 ). However, unlike PTPN14, which is defined as a tumor suppressor and particularly controls the Hippo signaling pathway ( Huang et al, 2013 ; Liu et al, 2013 ; Mello et al, 2017 ; Michaloglou et al, 2013 ; Wilson et al, 2014 ), PTPN21 is known to be upregulated in several types of cancer cells and is associated with EGFR activation and intracellular trafficking, implying that this protein might be potentially oncogenic rather than tumor-suppressive ( Carlucci et al, 2010 ; Plani-Lam et al, 2016 ; Roda-Navarro and Bastiaens, 2014 ; Wu et al, 2010 ). While the association between p53 and PTPN21 remains elusive, PTPN21 was reported to inhibit nuclear factor-κB transcriptional activity ( Cho et al, 2017 ), which is known to play a pivotal role in immune responses and be negatively regulated by p53 ( Carra et al, 2020 ; Jang et al, 2020 ; Pal et al, 2014 ; Schneider et al, 2010 ).…”
Section: Introductionmentioning
confidence: 99%
“…PTPN11 was suggested to impact the tumorigenesis and metastasis of CRC [31] and termed as a potential prognostic marker [32]. The data in one report showed that in patients with gastric B cell non-Hodgkin's lymphoma, PTPN21 is over expressed [33]. In ESCA, the expression levels of PTPN1, PTPN4, and PTPN12 were increased.…”
Section: Discussionmentioning
confidence: 99%
“…PTPN11 was also suggested to impact the tumorigenesis and metastasis of CRC (30) and termed as a potential prognostic marker (31). The data in one report showed that in patients with gastric B-cell non-Hodgkin's lymphoma, PTPN21 is over expressed (32). In ESCA, the expression levels of PTPN1, PTPN4, and PTPN12 were increased.…”
Section: Discussionmentioning
confidence: 99%