High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer

Chen, Zaiping; Wu, Guiyang; Ye, Fubo; Chen, Guoping; Fan, Qinghao; Dong, Hao; Zhu, Xiongwen; Wu, Chongshan

doi:10.1186/s12885-019-5673-6

Cited by 21 publications

(13 citation statements)

References 28 publications

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“…Furthermore, high expression levels of miR-203 and miR-21 in serum are associated with poor survival of patients with CRC ( 10 , 11 ). Analysis of The Cancer Genome Atlas (TCGA) database revealed that MMP19 is upregulated in patients with CRC and is associated with tumor progression ( 12 ). However, to the best of our knowledge, no study has directly screened mRNA profiles based on prognosis.…”

Section: Introductionmentioning

confidence: 99%

DEFB4A is a potential prognostic biomarker for colorectal cancer

Wang

Zhang

et al. 2020

Oncol Lett

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Colorectal cancer (CRC) is the third leading cause of cancer-associated mortality. The present study aimed to investigate novel biomarkers to predict prognosis and provide a theoretical basis for studies of the pathogenesis and the development of therapies for CRC. The present study compared mRNA expression levels of patients with CRC with short- and long-term prognosis and of individuals with and without tumors in The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were identified via volcano plot and Venn diagram analysis. Gene Ontology (GO) analysis and gene set enrichment analysis (GSEA) were performed to identify the functions of the DEGs, and the DEGs were further verified using clinical CRC samples. A total of 10 DEGs were identified as candidate genes using the TCGA database, and four DEGs [defensin β 4A ( DEFB4A ), hyaluronan binding protein 2 ( HABP2 ), oleoyl-ACP hydrolase and TBC1 domain family member 3G] were associated with poor prognosis of patients with CRC. Two DEGs ( DEFB4A and HABP2 ) were upregulated in tumor tissues of patients with CRC in the TCGA database. GO and GSEA analyses revealed that DEFB4A was highly associated with immunosuppression, participates in ‘myeloid leukocyte differentiation’, ‘leukocyte proliferation’ and ‘positive regulation of leukocyte-mediated immunity’, and was positively correlated with CD11b, CD14, CD45, CD163 and IL17A. Furthermore, DEFB4A expression was significantly upregulated in patients with large tumors, advanced cancer stage, lymph node metastasis and liver metastasis. Survival analysis revealed that DEFB4A upregulation was associated with poor prognosis. DEFB4A gene knockdown experiments demonstrated that DEF4BA promotes cell migration. These results indicated that DEFB4A potentially promotes tumor growth by regulating immunosuppressive activity and provided novel insights into the diagnosis and treatment of CRC.

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Section: Introductionmentioning

confidence: 99%

DEFB4A is a potential prognostic biomarker for colorectal cancer

Wang

Zhang

et al. 2020

Oncol Lett

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“…We also measured the expression of hyaluronic receptor CD44 [ 36 ] and metalloproteinase MMP19 [ 37 ] transcripts since they are associated to the metastatic potential of the PDAC. One is making bounds with the glycosaminoglycan while the other is degrading the proteins leading the way through the extracellular matrix.…”

Section: Resultsmentioning

confidence: 99%

Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice

Bintz

Abuelafia

Gerbe

et al. 2020

Biology

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TUFT cells have been described as strong modulators of inflammatory cells in several tissues including pancreas. TUFT cells, also known as DCLK1+ cells, are dependent of the transcriptional factor POU2F3. Several works report DCLK1+ cells in early stages of PDAC development suggesting an important role of TUFT cells in PDAC development. Therefore, we developed a mice model (PDX1-Cre;KrasG12D;Ink4afl/fl), known as PKI model, deficient or not of POU2F3. In this animal model, deficiency of POU2F3 results in the absence of TUFT cells in PDAC as expected. Although, tumor development and growth are not significantly influenced, the development of liver metastasis was almost completely inhibited in POU2F3-deficient mice. Surprisingly, the absence of metastasis was associated with a higher expression of epithelial-to-mesenchymal transition markers, but to a lower inflammatory microenvironment suggesting that inflammation influences metastasis production more than epithelial-to-mesenchymal transition in this animal model. We can conclude that POU2F3 could be a new therapeutic target for control PDAC progression.

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“…Expression levels of MMP10, MMP19, MMP24, and MMP25 were associated with prognosis in TCGA cohort of head and neck cancer by Kaplan-Meier analysis. Chongshan Wu demonstrated that the high expression of MMP19 was determined to be a poor prognostic factor in colorectal cancer (20). Trever G Bivona also suggested that MMP24 was a biomarker of tumor progression and worse outcomes in lung and/or gastric cancer patients (21).…”

Section: Discussionmentioning

confidence: 99%

MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients

Liang

Guan

et al. 2020

Front. Oncol.

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Background: MMP25 is a critical gene of matrix metalloproteinases (MMPs). However, the molecular mechanism of MMP25 in head and neck cancer pathogenesis remains unclear. Methods: MMP25 expression was analyzed using The Cancer Genome Atlas (TCGA) database, and its influence on clinical prognosis was performed using Kaplan-Meier and Cox regression analyses. The correlation between MMP25 and immune infiltration was investigated by CIBERSORT, TIMER, and ESTIMATE. In addition, the relationship between MMP25 expression and molecular mechanisms was analyzed by gene set enrichment analysis (GSEA), gene ontology (GO), and weighted gene co-expression network analysis (WGCNA). Results: MMP25 expression level correlated with prognosis and immune infiltrating levels, especially activated CD4 + memory T cells, in head and neck cancer. Moreover, MMP25 expression potentially mediated genes, such as IRF8, IKZF1, and DOCK2, and tumor-associated pathways, including p53 signaling, PI3K/AKT/mTOR signaling, and JAK/STAT signaling pathway. Conclusions: These findings suggested that MMP25 plays a critical role in the prognosis and immune infiltration level of head and neck cancer. In addition, MMP25 expression significantly correlated with the regulation of various oncogenes and tumor-related pathways.

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High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer

Cited by 21 publications

References 28 publications

DEFB4A is a potential prognostic biomarker for colorectal cancer

DEFB4A is a potential prognostic biomarker for colorectal cancer

Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice

MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients

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