High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma

Gu, Xuefeng; Fu, Maoying; Zhang, Ge; Zhan, Feng; Ding, Yuqin; Ni, Huihui; Zhang, Wei; Zhu, Yanfang; Tang, Xiaojun; Xiong, Lin; Jiang, Li; Qiu, Liang; Yuan, Man; Zhu, Jin

doi:10.1038/srep06625

Cited by 46 publications

(39 citation statements)

References 25 publications

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“…Increased MAGE-A9 expression was associated with a poor prognosis in patients with ESCC. The results of the present study were consistent with previous studies carried out in hepatocellular carcinoma and non-small cell lung cancer (7,11). Additionally, the Kaplan-Meier estimator analysis demonstrated that patients with ESCC with increased MAGE-A9 expression exhibited a markedly unfavorable outcome.…”

Section: Discussionsupporting

confidence: 94%

“…The biological functions of MAGE genes remain unknown, therefore MAGE-A may be identified as a target for cancer immunotherapy. MAGE-A9 has been studied in a number of types of cancer, including hepatocellular carcinoma, breast cancer, renal carcinoma, non-small cell lung cancer and laryngeal squamous cell carcinoma (11–14). MAGE-A9 has been associated with tumor recurrence and progression in bladder cancer (15).…”

Section: Introductionmentioning

confidence: 99%

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High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma

Cao

Xing

et al. 2017

Oncology Letters

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Melanoma-associated antigens (MAGEs) are a group of well-characterized members of the cancer/testis antigen family, which are expressed in a variety of malignant tumors. MAGE-A9, a subfamily of MAGE-As, has been studied in a number of types of cancer and have been associated with unfavorable survival outcome. However, the expression of MAGE-A9 in human esophageal squamous cell carcinoma (ESCC) and association of MAGE-A9 with the clinicopathological characteristics of ESCC, particularly prognostic characteristics, remains unknown. The present study aimed at determining the expression level of MAGE-A9 and at evaluating its clinical significance in human ESCC. Quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC) analyses were performed to characterize the expression of MAGE-A9 in ESCC tissues. Kaplan-Meier estimator survival and Coxs regression analyses were used to evaluate the prognosis of 103 patients with ESCC. The results of qPCR and IHC analysis revealed that the expression of MAGE-A9 was significantly increased in ESCC tissues, compared with that in healthy tissues. Furthermore, the expression level of MAGE-A9 protein in ESCC was significantly associated with the pathological grade (P=0.008), tumor size (P=0.027) and lymph node metastasis (P=0.009). Multivariate analysis using Coxs regression model identified that the expression level of MAGE-A9 and lymph node metastasis were independent prognostic factors for the overall survival rate of patients with ESCC (P=0.006 and P=0.001, respectively). The results of the present study are, to the best of our knowledge, the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for ESCC and that it may serve as a targeted therapy in the treatment of ESCC. Increased expression of MAGE-A9 indicated an unfavorable survival outcome in patients with ESCC.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma

Cao

Xing

et al. 2017

Oncology Letters

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“…Recently, it has been shown that MAGE-A9 expression in laryngeal, hepatocellular and renal cell carcinoma, as well as in breast, ovarian, lung and colorectal cancer, is a negative prognostic marker (20)(21)(22)(23)(24)(25)(26). Based on our patient cohort, we can confirm a significant correlation (P= 0.0468) between high MAGE-A9 expression levels and lower overall patient survival.…”

Section: Discussionsupporting

confidence: 74%

“…Han et al showed that there is a significant correlation between high MAGE-A9 expression levels and a low overall survival in laryngeal squamous cell carcinoma patients (20). Similar findings were reported for hepatocellular and renal cell carcinoma as well as breast, ovarian, lung and colorectal cancer (21)(22)(23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 60%

MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation

et al. 2018

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Abstract. Radiotherapy alone, or as an addition to surgery is important for the treatment of head and neck squamous cell carcinoma (HNSCC). In addition to their expression in germ cells, melanoma associated antigens-A (MAGE-A) are only expressed in malignant tissue. Notably, there is a known correlation between MAGE-A9 expression and poor prognosis in HNSCC patients. However, current knowledge regarding the function of MAGE-A9 expression, particularly in the context of irradiation, is limited. MAGE-A9 expression in 37 oral squamous cell carcinoma patents was immunohistochemically determined and analyzed for overall survival by the Kaplan-Meier log-rank test. Next, the expression of MAGE-A9 was determined by reverse transcription-quantitative polymerase chain reaction in HNSCC cell lines prior to and following irradiation with 2 Gray. The radiosensitivity of each cell line was determined using a clonogenic survival assay. There was a significantly (P=0.0468) longer overall survival in patients with a low level of MAGE-A9 expression. The median overall survival in patients with high MAGE-A9 expression was 47% compared to 73% in the group with low MAGE-A9 expression. The cell lines revealed a distinct expression pattern of MAGE-A9. Following irradiation of the cell lines, a significant enhancement of MAGE-A9 mRNA expression levels was observed. The most prominent alteration in MAGE-A9 expression was observed in the most radioresistant cell line. A high MAGE-A9 expression level correlates significantly with lower overall survival in HNSCC patients. Additionally, irradiation increased the MAGE-A9 mRNA levels in all five HNSCC cell lines, and the most resistant cell line demonstrated the greatest increase in MAGE-A9 expression following irradiation.

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“…All 100 HCC samples of TMA were entered into the survival analyses. Clinical staging was classified according to the 2002 American Joint Committee on Cancer/International Union Against Cancer TNM staging system [24]. All enrolled patients signed written informed consent and all experimental procedures were implemented following the approved protocols of Qiqhar Medical University.…”

Section: Methodsmentioning

confidence: 99%

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

Chen

Yan²,

Lang

et al. 2017

Diagn Pathol

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BackgroundSESN2 plays important roles in the regulation of cell survival, cell protection, and tumor suppression. However, the relationship between SESN2 expression and the clinicopathological attributes of hepatocellular carcinoma (HCC) is barely investigated.MethodsOne-step quantitative reverse transcription PCR, Western blotting analysis in 15 fresh HCC tissues, and immunohistochemistry (IHC) analysis in a tissue microarray (TMA) containing 100 HCC cases were performed to examine SESN2 expression. Survival analyses by Cox regression method and Kaplan-Meier curve were performed to describe the overall survival of 100 HCC patients.ResultsThe SESN2 expression in HCC tissues declined dramatically compared with the corresponding noncancerous tissues, and SESN2 expression was remarkably associated with HBV infection (p = 0.019), HCV infection (p = 0.001), and lymph node metastasis (p = 0.033). Survival analysis further demonstrated that SESN2 expression could serve as an independent prognostic biomarker for overall survival in univariate (p = 0.001) and multivariate analyses (p = 0.003).ConclusionThe data are the first to indicate that SESN2 might be a novel prognostic marker for HCC and that elevated SESN2 expression predicts advantageous outcomes in HCC patients.

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High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma

Cited by 46 publications

References 25 publications

High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma

High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma

MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

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