High expression of MACC1 predicts poor prognosis in patients with osteosarcoma

Abstract

Increasing evidence has demonstrated that high metastasis-associated in colon cancer-1 (MACC1) level is tightly associated with the development, progression, and poor prognosis of a variety of tumors. However, the relationship between MACC1 and the occurrence, development, and progression of osteosarcoma (OS) remains to be clarified. To facilitate and deepen the understanding of the associations of MACC1 with the development and progression of OS, in the current study, we detected the expressions of MACC1 mRNA and protein, and investigated the relationship between MACC1 expression and prognosis of the patients with OS. Our findings demonstrated that expressions of MACC1 mRNA and protein in OS tissues were significantly higher than those in paired normal bone tissues (P < 0.05). Additionally, the level of MACC1 mRNA in the patients with higher clinical stage and distant metastasis was markedly higher than those with lower clinical stage and without metastasis (P < 0.05). Furthermore, high MACC1 level was closely correlated with clinical stage and distant metastasis (P < 0.05), but not related to the patients' age, gender, tumor size, and anatomical location (P > 0.05). Stepwise investigation revealed that survival time of the patients with high MACC1 level was obviously lower than that with low MACC1 level (P < 0.05). Collectively, our data suggest that MACC1 may play important roles in the development and progression of OS, and thus may be considered as a novel molecular target for therapy of the patients with OS.

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis

“…58 It was later shown that this gene plays a significant role in a number of other cancers, such as ovarian, liver, pancreatic, lung, breast, and gastric cancers; esophageal osteosarcoma; and glioma. [59][60][61][62][63][64][65][66][67] This gene is not known to play a role in thyroid cancer at this time.…”

Genetic Variation in Metastasis-Associated in Colon Cancer-1 and the Risk of Breast Cancer Among the Chinese Han Population

“…These features designate MACC1 as a gene that can be used to predict the risk of metastasis and guide further diagnostic and therapeutic decisions. Originally discovered in colon cancer, MACC1 overexpression has been demonstrated to promote tumor proliferation, invasion, and metastasis in a wide spectrum of solid tumors including colon cancer, 15 gastric carcinoma, 16 hepatocellular carcinoma, 17 , 18 osteosarcoma, 19 glioma, 20 , 21 lung, 22 , 23 esophageal, 24 pancreatic, 25 ovarian, 26 , 27 cervical cancer, and BC. 9 , 28 …”

MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells

“…Metastasis-associated in colon cancer-1 (MACC1) is an oncogene first discovered in colon cancer [ 11 ], where its main action was thought to be promotion of metastasis. MACC1 was subsequently shown to be overexpressed in many other cancers [ 12 - 15 ], including GC [ 16 ]. Previous studies in our laboratory verified that patients exhibiting high MACC1 expression have poor outcomes, and that MACC1 enhances GC cell proliferation, invasion and migration in vitro and in vivo [ 16 ].…”