High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma

Shen, An; Ma, Jingfei; Hu, Xiaolin; Cui, Xinjiang

doi:10.3892/ol.2020.11490

Cited by 16 publications

(10 citation statements)

References 27 publications

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“…We found that over-expression of SNHG12 and SNHG20 in LIHC ( Figure 3 ) had significant alteration across cancer stages, representing their roles in cancer progression and invasion. These lncRNAs identified in our study were previously reported in their corresponding cancers ( Yang et al, 2015 ; Zhang et al, 2016 ; Li et al, 2019 ; Tamang et al, 2019 ; Feng et al, 2020a ; Niu et al, 2020a ; Martinez-Barriocanal et al, 2020 ; Shen et al, 2020 ; Zeng et al, 2020 ; Zhang et al, 2020b ; Zheng et al, 2020 ) but a comprehensive investigation of distinct or shared lncRNAs in these cancers has not yet been conducted.…”

Section: Discussionsupporting

confidence: 51%

LncRNA–miRNA–mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs

et al. 2022

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Gastrointestinal (GI) cancers are responsible for approximately half of cancer-related deaths, highlighting the need for the identification of distinct and common features in their clinicopathological characteristics. Long ncRNA (lncRNAs), which are involved in competitive endogenous RNA (ceRNA) networks with critical roles in biological processes, constitute a substantial number of non-coding RNAs. Therefore, our study aimed to investigate the similarities and differences in the ceRNA networks of The Cancer Genome Atlas (TCGA)-GI cancers. We performed a comprehensive bioinformatics analysis of ceRNA networks for TCGA-GI cancers in terms of the deferential mRNA, lncRNA, and miRNA expression levels, ceRNA networks, overall survival analysis, correlation analysis, pathological cancer stages, and gene set enrichment analysis. Our study revealed several common and distinct mRNAs and lncRNAs with prognostic values in these networks. It was specifically noteworthy that MAGI2-AS3 lncRNA was found to be shared in almost all GI cancers. Moreover, the most common shared mRNAs between GI cancers were MEIS1, PPP1R3C, ADAMTSL3, RIPOR2, and MYLK. For each cancer ceRNA network, we found that the expression level of a number of lncRNAs and mRNAs was specific. Furthermore, our study provided compelling evidence that several genes, most notably KDELC1, can act as novel proto-oncogenes in cancers. This, in turn, can highlight their role as new prognostic and therapeutic targets. Moreover, we found cell cycle and extracellular matrix structural constituent as the top shared KEGG and molecular function, respectively, among GI cancers. Our study revealed several known lncRNAs and known and unknown mRNAs in GI cancers with diagnostic and prognostic values.

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Section: Discussionsupporting

confidence: 51%

LncRNA–miRNA–mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs

et al. 2022

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“…In recent years, according to detecting the tissues and plasma of cancer patients by real-time reverse transcription-polymerase chain reaction (RT-PCR), a high quantity of aberrantly expressed lncRNAs is found to participate in tumor metabolism to promote tumor development in different ways [57]. It has been found that only 1.5% of nucleic acid sequences were coding that is they make proteins while the rest 98.5% of the sequences are noncoding RNAs in three billion base pairs of the human genome, the latter regulated gene expression and maintained intracellular homeostasis through chromosome alteration, regulation of transcription, Zhang 2020 [28] Zhang 2020 [29] Dong 2016 [24] Shi 2015 [25] Shen2020 [27] Jiao2020 [30] Xiao2020 [31] Zeng2019 [53] Bai2019 [54] Nie2019 [33] Fu2019 [34] Zhao2019 [35] Pan2019 [36] Wang2019 [37] Guo2019 [38] Wang2019 [39] Zhou2019 [41] Yu2020 [42] Huang2018 [43] Jin2018 [46] Li2018 [48] Zeng2018 [51] Liang2021 [52] Overall, DL (I 2 = 0.0%, p = 0.829) Overall, IV and posttranscriptional regulation. LncRNA dysregulation can cause chromosome loss and translocation, leading to the occurrence of cancer [58,59].…”

Section: Discussionmentioning

confidence: 99%

The Association between Long Noncoding RNA over Expression and Poor Prognosis of Liver Cancer: A Meta-Analysis

Wang

Sheng

Zhang

et al. 2021

Journal of Healthcare Engineering

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Background. Long noncoding RNA (lncRNA) is considered to be a mediator of carcinogenesis, which may be associated with liver cancer survival. However, the relationship remains inconclusive. Meta-analysis was conducted to analytically review the association between the lncRNA expression level and clinicopathological characteristics and prognostic value of hepatic carcinoma. Materials and Methods. Four databases including Embase, PubMed, Web of Science, and the Cochrane Library were searched to collect studies about the relation between lncRNA overexpression and prognosis of liver cancer, dating from the earliest records of these databases to March 2021. Two researchers independently screened the data and literature to perform a stringent evaluation of the quality of material involved in the study. Meta-analysis was performed by Stata 16.0 software on 42 case-control studies with 6293 samples. Results. The outcomes of meta-analysis are presented as follows: lncRNA overexpression patients had later TNM stage (OR = 0.36, 95% CI (0.31, 0.41), P < 0.001), lower histological grade (OR = 0.56, 95%CI (0.49, 0.65), P < 0.001), more vascular invasion (OR = 2.02, 95% CI (1.74, 2.35), P < 0.001), bigger tumor size (OR = 2.28, 95% CI (2.00, 2.60), P < 0.001), more severe liver cirrhosis (OR = 1.39, 95% CI(0.1.16, 1.66), P < 0.001), more likely to metastasize (OR = 1.80, 95%CI(1.49, 2.18), P < 0.001), and more tumor numbers (OR = 0.72, 95% CI (0.62, 0.84), P < 0.05). lncRNA over expression patients had shorter OS (HR = 2.32, 95 CI% (2.08, 2.59), P < 0.01, RFS (HR = 2.19, 95 CI% (1.72, 2.78), P < 0.01), and DFS (HR = 2.01, 95 CI% (1.57, 2.57), P < 0.01). Conclusions. Overexposure of lncRNA is a poor prognostic feature for patients with hepatic carcinoma. The scope of our study was limited because of a lack of relevant research and the poor representativeness and varying quality of the studies involved in the current meta-analysis. Our conclusion still requires higher studies for further validation. This trial is clinically registered with CRD4201920620.

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“…Interestingly, Cox regression analyses confirm the predictive value of SNHG7 as an independent prognostic factor among cancerous patients. This is particularly reported in several district experiments on human malignancies such as gastric cancer, cervical cancer, HCC, and liver metastasis following hepatectomy in CRC patients ( Table 2 ) ( Zeng et al, 2019 ; Zhang et al, 2020a ; Zhang et al, 2020c ; Shen et al, 2020 ). As for diagnostic values, an area under curve (AUC) of 0.84 in the receiver operating characteristic (ROC) curve is reported for SNHG7 in CRC patients ( Hu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 70%

Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials

Najafi

Ghafouri‐Fard

Hussen

et al. 2022

Front. Cell Dev. Biol.

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Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts characterized with more than 200 nucleotides of length. Unlike their names, some short open reading frames are recognized for them encoding small proteins. LncRNAs are found to play regulatory roles in essential cellular processes such as cell growth and apoptosis. Therefore, an increasing number of lncRNAs are identified with dysregulation in a wide variety of human cancers. SNHG7 is an lncRNA with upregulation in cancer cells and tissues. It is frequently reported with potency of promoting malignant cell behaviors in vitro and in vivo. Like oncogenic/tumor suppressor lncRNAs, SNHG7 is found to exert its tumorigenic functions through interaction with other biological substances. These include sponging target miRNAs (various numbers are identified), regulation of several signaling pathways, transcription factors, and effector proteins. Importantly, clinical studies demonstrate association between high SNHG7 expression and clinicopathological features in cancerous patients, worse prognosis, and enhanced chemoresistance. In this review, we summarize recent studies in three eras of cell, animal, and human experiments to bold the prognostic, diagnostic, and therapeutic potentials.

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High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma

Cited by 16 publications

References 27 publications

LncRNA–miRNA–mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs

LncRNA–miRNA–mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs

The Association between Long Noncoding RNA over Expression and Poor Prognosis of Liver Cancer: A Meta-Analysis

Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials

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