High expression of KNL1 in prostate adenocarcinoma is associated with poor prognosis and immune infiltration

Abstract

Prostate adenocarcinoma (PRAD) is a common malignancy with increasing morbidity and mortality. Kinetochore scaffold 1 (KNL1) has been reported to be involved in tumor progression and prognosis in other tumors, but its role in PRAD has not been reported in detail. KNL1 expression analysis, clinicopathological parameters analysis, prognostic correlation analysis, molecular interaction network and functional abdominal muscle analysis and immune infiltration analysis by using multiple online databases and downloaded expression profile. The results suggest that KNL1 is highly expressed in PRAD, which is associated with worse prognosis in PRAD patients. KnL1-related genes are highly enriched in mitotic function, which is considered to be highly related to the development of cancer. Finally, KNL1 expression is associated with a variety of tumor infiltrating immune cells, especially Treg and Th2 cells. In conclusion, our findings provide preliminary evidence that KNL1 may be an independent prognostic predictor of PRAD and is associated with immune infiltration.

KNL1 is a lung cancer prognostic biomarker associated with the immune microenvironment

“…[10,11] This gene may be crucial in immunotherapy and is linked to the clinical prognosis of individuals with prostate cancer. [12] According to bioinformatics research, KNL1 is signi cantly expressed in gastric cancer and plays a pivotal role in the tumour development. [13] The research ndings indicates that KNL1 is a signi cant predictor of prognosis in LUAD and is linked to the miR-139-5p target.…”