High expression of Ki-67 acts a poor prognosis indicator in locally advanced nasopharyngeal carcinoma

Zhao, Yajie; Shen, Lin; Huang, Xinqiong; Jiang, Di; Huang, David; Fu, Jun; Li, Zhanzhan; Zhang, Guangying; Shen, Liangfang

doi:10.1016/j.bbrc.2017.09.118

Cited by 22 publications

(23 citation statements)

References 42 publications

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“…And 30 patient specimens in the validation cohort (including 16 radiosensitive NPC patients and 14 radioresistant NPC patients) were used for RT-qPCR. Here, we defined the patients with <40% reduction of tumour size after radiation treatment as radioresistant NPC patients, and the patients with >60% reduction of tumour size as radiosensitive NPC patients 13,14 . It must be noted that, all patients defined as radiosensitive were treated with definitive radiation therapy only, while the patients defined as radioresistant were treated with radiotherapy with or without chemotherapy.…”

Section: Methodsmentioning

confidence: 99%

Identification of non-invasive biomarkers for predicting the radiosensitivity of nasopharyngeal carcinoma from serum microRNAs

Zhu

et al. 2020

Sci Rep

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Serum microRNAs (miRNAs) have been reported as novel biomarkers for various diseases. But circulating biomarkers for predicting the radiosensitivity of nasopharyngeal carcinoma (NPC) have not been used in clinical practice. To screen out of differently expressed serum miRNAs from NPC patients with different radiosensitivity may be helpful for its individual therapy. NPC patients with different radiosensitivity were enrolled according to the inclusion and exclusion criteria. RNA was isolated from serum of these NPC patients before treatment. We investigated the differential miRNA expression profiles using microarray test (GSE139164), and the candidate miRNAs were validated by reverse transcription-quantitative real time polymerase chain reaction (RT-qPCR) experiments. Receiver operating characteristic (ROC) analysis has been applied to estimate the diagnostic value. In this study, 37 serum-specific miRNAs were screened out from 12 NPC patients with different radiosensitivity by microarray test. Furthermore, RT-qPCR analysis confirmed that hsa-miR-1281 and hsa-miR-6732-3p were significantly downregulated in the serum of radioresistant NPC patients (P < 0.05), which was consistent with the results of microarray test. ROC curves demonstrated that the AUC for hsa-miR-1281 was 0.750 (95% CI: 0.574–0.926, SE 87.5%, SP 57.1%). While the AUC for hsa-miR-6732-3p was 0.696 (95% CI: 0.507–0.886, SE 56.3%, SP 78.6%). These results suggested that hsa-miR-1281 and hsa-miR-6732-3p in serum might serve as potential biomarkers for predicting the radiosensitivity of NPC.

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Section: Methodsmentioning

confidence: 99%

Identification of non-invasive biomarkers for predicting the radiosensitivity of nasopharyngeal carcinoma from serum microRNAs

Zhu

et al. 2020

Sci Rep

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“…A total dose of 62.72-80.64 Gy in 33 fractions to the PGTVnx (GTVnx + 3 mm margin), 69.96-72.6 Gy in 33 fractions to the PGTVnd (GTVnd + 3 mm margin), 59.4-64.0 Gy in 33 fractions to the PTV1 and 50.0-54.0 Gy in 28 fractions to the PTV2 were prescribed. All patients were treated with 1 fraction daily, 5 days/week, for 5-6 weeks (23,24). Dose limits for the critical tissue structures and the plan evaluation were designed according to the Radiation Therapy Oncology Group 0225 (25).…”

Section: Patient Characteristicsmentioning

confidence: 99%

Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy

et al. 2018

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Abstract. The present study retrospectively analyzed the prognostic factors of 135 patients with locally advanced nasopharyngeal carcinoma (NPC) who received intensity modulated radiation therapy between August 2008 and January 2012 at Xiangya Hospital of Central South University. Patients were staged from III-IVA according to the 7th American Joint Committee on Cancer staging system. Using Statistical Analysis System 9.3 software, the present study demonstrated that, among these 135 patients, the 5-year overall survival, the 5-year local relapse-free survival, and the 5-year disease metastasis-free survival were 84, 82, and 78%, respectively. Multivariate Cox regression analysis identified that targeted treatment [hazard ratio (95% confidence interval), 2.642 (1.001, 6.972); P=0.0497] served as an independent negative prognostic factor in locally advanced NPC. The results of immunostaining revealed that the staining intensity of the radiation-resistant group was increased compared with that of the radiation-sensitive group. These results demonstrate that a high expression of EGFR may be associated with radiation resistance, and targeted treatment may not be effective in patients with locally advanced nasopharyngeal carcinoma with low expression of EGFR.

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“…The results revealed that the survival rate of patients with high expression of Ki67 was lower, which is similar to our results. In another study, the high expression of Ki67 was considered to be beneficial to anti-radiation, leading to local recurrence and distant metastasis, which would result in poor prognosis (26). By analyzing the patients' clinicopathologic features, it was also found, in the present study, that the patients in stages I and Ⅱ have lower expression of Ki67 and higher expression of miR-34a Exp(B) 95% CI ----------------------------------------------------------- compared with those in stage Ⅲ and Ⅳ.…”

Section: Correlation Analysis Of Mir-34a and Ki67 Expression Levels Imentioning

confidence: 99%

Expression of miR‑34a and Ki67 in nasopharyngeal carcinoma and the relationship with clinicopathological features and prognosis

2019

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Expression levels of miR-34a and Ki67 in nasopharyngeal carcinoma (NPC) and the relationship with clinicopathological features and prognosis were studied. A prospective study was performed on 56 cases of NPC tissues and 56 cases of adjacent tissues collected in Xiangyang No. 1 People's Hospital. The expression levels of miR-34a, Ki67 in NPC and adjacent tissues were detected by RT-qPCR. The association among the expression levels of miR-34a and Ki67, the clinicopathological features and prognosis of patients was analyzed. The relative expression levels of miR-34a in 56 cases of NPC were lower than those of the adjacent tissues. The expression of miR-34a in NPC was significantly associated with bone metastasis and TNM staging (P<0.001). The relative expression of Ki67 in 56 cases of NPC was higher than that of the adjacent tissues. The expression of Ki67 in NPC was significantly associated with lymphatic metastasis and TNM staging (P<0.001). The 5-year survival of patients with low expression of miR-34a was significantly lower than that of patients with high expression, and the survival of patients with high expression of Ki67 was significantly lower than that of patients with low expression. According to Pearson's correlation analysis, Ki67 expression was negatively correlated with miR-34a expression in NPC tissues. In conclusion, the expression of Ki67 in NPC was upregulated, while the expression of miR-34a in NPC was downregulated. miR-34a expression in NPC was significantly associated with bone metastasis and TNM staging, and Ki67 expression in NPC was significantly associated with lymphatic metastasis and TNM staging. In addition, there was a negative correlation between miR-34a and Ki67 expression levels, and the two can be used as predictors of NPC-associated mortality. The expression levels of miR-34a and Ki67, as well as TNM staging were associated with the prognosis of NPC patients.

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High expression of Ki-67 acts a poor prognosis indicator in locally advanced nasopharyngeal carcinoma

Cited by 22 publications

References 42 publications

Identification of non-invasive biomarkers for predicting the radiosensitivity of nasopharyngeal carcinoma from serum microRNAs

Identification of non-invasive biomarkers for predicting the radiosensitivity of nasopharyngeal carcinoma from serum microRNAs

Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy

Expression of miR‑34a and Ki67 in nasopharyngeal carcinoma and the relationship with clinicopathological features and prognosis

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