High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma

Jiang, Si‐Cong; Li, Daojing; Liang, Zhongxing; Wang, Yanhua; Pei, Xin; Tang, Jianjun

doi:10.1177/1724600819896374

Cited by 5 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47,48 Recently it also showed that IGBP1 is upregulated in esophageal squamous cell carcinoma (ESCC), and its expression is significantly associated with ESCC patient survival. 49 IGBP1 is also expressed in the heart, but its function has not been studied in the heart yet. In our study, we have identified that IGBP1P1 is upregulated in the human disease model in vitro , and its depletion could reduce hypoxia-induced cell size and improve cardiac contractility in human cardiac tissue mimetics.…”

Section: Discussionmentioning

confidence: 99%

CVD-associated SNPs with regulatory potential drive pathologic non-coding RNA expression

Zhu

Baumgarten

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) appearing in non-coding genomic regions in CVDs. The SNPs may alter gene expression by modifying transcription factor (TF) binding sites and lead to functional consequences in cardiovascular traits or diseases. To understand the underlying molecular mechanisms, it is crucial to identify which variations are involved and how they affect TF binding. Methods: The SNEEP (SNP exploration and analysis using epigenomics data) pipeline was used to identify regulatory SNPs, which alter the binding behavior of TFs and link GWAS SNPs to their potential target genes for six CVDs. The human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CMs), monoculture cardiac organoids (MCOs) and self-organized cardiac organoids (SCOs) were used in the study. Gene expression, cardiomyocyte size and cardiac contractility were assessed. Results: By using our integrative computational pipeline, we identified 1905 regulatory SNPs in CVD GWAS data. These were associated with hundreds of genes, half of them non-coding RNAs (ncRNAs), suggesting novel CVD genes. We experimentally tested 40 CVD-associated non- coding RNAs, among them RP11-98F14.11, RPL23AP92, IGBP1P1, and CTD-2383I20.1, which were upregulated in hiPSC-CMs, MCOs and SCOs under hypoxic conditions. Further experiments showed that IGBP1P1 depletion rescued expression of hypertrophic marker genes, reduced hypoxia-induced cardiomyocyte size and improved hypoxia-reduced cardiac contractility in hiPSC-CMs and MCOs. Conclusions: IGBP1P1 is a novel ncRNA with key regulatory functions in modulating cardiomyocyte size and cardiac function in our disease models. Our data suggest ncRNA IGBP1P1 as a potential therapeutic target to improve cardiac function in CVDs.

show abstract

Section: Discussionmentioning

confidence: 99%

CVD-associated SNPs with regulatory potential drive pathologic non-coding RNA expression

Zhu

Baumgarten

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…IGBP1 is a novel biomarker in lupus nephritis (LN) patients, its expression level is increased in the plasma and urine of patients with LN compared with systemic lupus erythematosus (SLE) patients without nephritis and healthy controls [ 54 , 55 ]. Recently it also showed that IGBP1 is upregulated in esophageal squamous cell carcinoma (ESCC), and its expression is significantly associated with ESCC patient survival [ 56 ]. IGBP1 is also expressed in the heart, but its function has not been studied in the heart yet.…”

Section: Discussionmentioning

confidence: 99%

CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

Zhu¹,

Baumgarten²,

Wu³

et al. 2023

Hum Genomics

View full text Add to dashboard Cite

Background Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) appearing in non-coding genomic regions in CVDs. The SNPs may alter gene expression by modifying transcription factor (TF) binding sites and lead to functional consequences in cardiovascular traits or diseases. To understand the underlying molecular mechanisms, it is crucial to identify which variations are involved and how they affect TF binding. Methods The SNEEP (SNP exploration and analysis using epigenomics data) pipeline was used to identify regulatory SNPs, which alter the binding behavior of TFs and link GWAS SNPs to their potential target genes for six CVDs. The human-induced pluripotent stem cells derived cardiomyocytes (hiPSC-CMs), monoculture cardiac organoids (MCOs) and self-organized cardiac organoids (SCOs) were used in the study. Gene expression, cardiomyocyte size and cardiac contractility were assessed. Results By using our integrative computational pipeline, we identified 1905 regulatory SNPs in CVD GWAS data. These were associated with hundreds of genes, half of them non-coding RNAs (ncRNAs), suggesting novel CVD genes. We experimentally tested 40 CVD-associated non-coding RNAs, among them RP11-98F14.11, RPL23AP92, IGBP1P1, and CTD-2383I20.1, which were upregulated in hiPSC-CMs, MCOs and SCOs under hypoxic conditions. Further experiments showed that IGBP1P1 depletion rescued expression of hypertrophic marker genes, reduced hypoxia-induced cardiomyocyte size and improved hypoxia-reduced cardiac contractility in hiPSC-CMs and MCOs. Conclusions IGBP1P1 is a novel ncRNA with key regulatory functions in modulating cardiomyocyte size and cardiac function in our disease models. Our data suggest ncRNA IGBP1P1 as a potential therapeutic target to improve cardiac function in CVDs.

show abstract

Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress

Hali

Wadzinski

Kowluru

2022

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma

Cited by 5 publications

References 25 publications

CVD-associated SNPs with regulatory potential drive pathologic non-coding RNA expression

CVD-associated SNPs with regulatory potential drive pathologic non-coding RNA expression

CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes

Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress

Contact Info

Product

Resources

About