High expression of FOXC1 is associated with poor clinical outcome in non-small cell lung cancer patients

Abstract

The aim of this study was to detect FOXC1 expression in human non-small cell lung cancer (NSCLC) and to analyze its association with prognosis of NSCLC patients. Expressional levels of FOXC1 mRNA and protein in 30 cases of NSCLC and corresponding non-tumor tissue samples were examined by quantitative real-time PCR and Western blotting. Immunohistochemistry was performed to detect the expression of FOXC1 in 125 NSCLC tissues. We found that the expression levels of FOXC1 mRNA and protein in NSCLC tissues were significantly higher than those in corresponding non-tumor tissues. High-level FOXC1 expression was correlated with poor tumor differentiation, tumor-node-metastasis stage, and lymph node metastasis. Patients with high expression levels of FOXC1 showed lower overall survival rate than those with low expression levels. Multivariate analysis showed that high FOXC1 protein expression was an independent prognostic factor for NSCLC patients. Our study suggests that over-expression of FOXC1 may play an important role in the progression of NSCLC, and FOXC1 expression may offer a valuable marker for predicting the outcome of patients with NSCLC.

Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice

“…Recent studies reported that FoxC1 is a master regulator of cancer invasion and metastasis. High expression of FoxC1 was associated with microvascular invasion, tumor-node-metastasis (TNM) stage, and poor prognosis in several human cancers 12,13 . We previously reported that FoxC1 promotes HCC metastasis through up-regulating Snai1 and NEDD9 expression, and high expression of FoxC1 indicates poor prognosis in human HCC patients 14 .…”

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

“…Elevated expression of FOXC1 also predicts poor overall survival in other cancers such as lung cancer (Wei et al, 2012) and hepatocellular carcinoma (Xia et al, 2013). A recent study has shown that NF-κB signaling mediates the function of FOXC1 in BLBC cell proliferation and invasion (Wang et al, 2012).…”

The expression and functional role of a FOXC1 related mRNA-lncRNA pair in oral squamous cell carcinoma

“…Several recent studies have reported that FOXC1 overexpression is strongly correlated with poor survival in the patients of multiple cancers such as breast cancer, pancreatic ductal adenocarcinoma, non-small cell lung cancer, or hepatocellular carcinoma [6–11]. However, overexpression of FOXC1 has not been reported in OSCC yet.…”