High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer

Zhang, Shengjie; Wang, Yi; Li, Yuan; Hu, Can; Xu, Zhiyuan; Cheng, Xiuzhen

doi:10.21037/tcr-22-1348

Cited by 3 publications

(1 citation statement)

References 40 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CerS4 exhibits high expression levels in several cancers. Analysis of cancer tissues from patients has revealed elevated levels of CerS5, both in mRNA expression and protein levels, in many cancers, such as colorectal and gastric cancer (Fitzgerald et al, 2015;Zhang et al, 2022). CerS5 is reported as a marker in colorectal cancer (Kijanka et al, 2010).…”

Section: Ceramide Synthasesmentioning

confidence: 99%

Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

Hernandez-Corbacho,

Canals

2023

Mol Pharmacol

View full text Add to dashboard Cite

Acyltransferase enzymes (EC 2.3.) are a large group of enzymes that transfer acyl groups to a large variety of substrates. This review focuses on fatty acyltransferases involved in the biosynthetic pathways of glycerolipids and sphingolipids and how these enzymes have been pharmacologically targeted in their biological context. Glycerolipids and sphingolipids, commonly treated independently in their regulation and biological functions, are put together to emphasize the parallelism in their metabolism and bioactive roles.Furthermore, a newly considered signaling molecule, 1-O-acylceramide, resulting from the acylation of ceramide by DGAT2 enzyme, is discussed. Finally, the implications of DGAT2 as a putative Ceramide AcylTransferase (CAT) enzyme, with a putative dual role in TAG and 1-O-acylceramide generation, are explored.

show abstract

Section: Ceramide Synthasesmentioning

confidence: 99%