High expression of astrocyte elevated gene-1 (AEG-1) is associated with progression of cervical intraepithelial neoplasia and unfavorable prognosis in cervical cancer

Abstract

BackgroundAstrocyte elevated gene-1(AEG-1) plays an important role in the development and progression of certain types of human cancers. However, the expression dynamics of AEG-1 in cervical cancer and its clinical/prognostic significance are unclear.MethodIn present study, the methods of tissue microarrays (TMA) and immunohistochemistry (IHC) were utilized to investigate AEG-1 expression in cervical intraepithelial neoplasia (CIN) and cervical cancer. Receiver operating characteristic (ROC) curve analysis, χ2 test, Kaplan-Meier plots, and multivariate Cox regression analysis were used to analyze the data.ResultsThe expression level of AEG-1 was increased from CIN I to CIN III. High expression of AEG-1 could be observed in 61.1% (55/90) of cervical cancer. Moreover, high expression of AEG-1 correlated with tumor size and lymph node metastasis (all P <0.05). More importantly, high expression of AEG-1 was closely associated with cervical cancer patient shortened survival time as evidenced by univariate and multivariate analysis (P <0.05).ConclusionsOur data suggest for the first time that high expression of AEG-1 is associated significantly with progression of cervical cancer. AEG-1 overexpression, as examined by IHC, has the potential to be used as an immunomarker to predict prognosis of cervical cancer patients.

Astrocyte Elevated Gene-1 Promotes Progression of Cervical Squamous Cell Carcinoma by Inducing Epithelial-Mesenchymal Transition via Wnt Signaling

“…6,9,10,18,19 In our study, AEG-1 overexpression was found to be significantly associated with lymph node metastasis, parametrial involvement, submucosa stromal invasion, and vascular invasion of CSCC. The results partly accorded with the studies of Huang et al 20 and Long et al 21 Huang et al 20 reported that a high level of AEG-1 correlated with lymphatic metastasis and tumor size of cervical cancer, but they did not present the correlation of AEG-1 with the parametrial involvement, stromal invasion, and vascular invasion of cervical cancer. Long et al 21 reported that AEG-1 was related to the clinical stage of cervical carcinoma.…”

Metadherin is required for the proliferation, migration, and invasion of esophageal squamous cell carcinoma and its meta-analysis

“…Additionally, multiple studies have suggested that MTDH was associated with tumor invasion and migration. [19][20][21][22][23] We confirmed that MTDH inhibited ESCC cell migration and invasion in vitro, indicating that upregulation of MTDH was significantly associated with metastasis and poorer prognosis of patients with ESCC, which was further verified with meta-analysis carried out on the studies regarding MTDH in SCC. [19][20][21][22][23][24][25][26][27][28] In our meta-analysis, we found that there were significant relationships between MTDH expression in SCC and NAT; SCC tissues with and without lymph node metastasis; clinical stage I and II vs clinical stage III and IV; and T1-T2 vs T3-T4 tissues, [19][20][21][22][23][24][25][26][27][28] which may imply the possibility of using the MTDH expression level as a clinical biomarker of SCC.…”

“…Consequently, we had meta-analyzed the expression of MTDH in SCC through retrieving the relevant literature. Eventually, the 10 eligible studies 6,11,[19][20][21][22][23][24][25][26] were identified and selected (Table III). MTDH positivity and overexpression were significantly different between SCC and its paired normal 0.53]) (Fig 6, C and D).…”

MicroRNA-1297 inhibits metastasis and epithelial-mesenchymal transition by targeting AEG-1 in cervical cancer

“…AEG-1, which is also called astrocyte elevated gene-1, has been recognized as a key regulator in cancer initiation, development and progression in different types of cancer (28). AEG-1 promoted cell proliferation through the FOXO1/PI3K/AKT signaling pathway in breast cancer (29).…”