High Expression of AhR and Environmental Pollution As AhR Linked Ligands Impact on Oncogenic Signaling Pathways in Western Patients With Diffuse Gastric Cancers. A Pilot Study
Martine Perrot-Applanat,
Cynthia Pimpie,
Sophie Vacher
et al.
Abstract:Diffuse type of gastric cancer (GC) has an increasing prevalence worldwide, especially in Western countries, is usually diagnosed at advanced stages, and has no efficacious treatment options. Epidemiological studies have reported an increased mortality from GC after occupational exposure to well-studied pro-carcinogen that are metabolically activated by Cyp P450 enzymes through aryl hydrocarbon receptor (AhR). Substantial studies support the involvement of AhR in gastric carcinogenesis. However, little is know… Show more
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