High expression levels of circulating <scp>microRNA</scp>‐122 and <scp>microRNA</scp>‐222 are associated with obesity in children with Mayan ethnicity

González-Arce, Larissa Michelle; Lara-Riegos, Julio; Pérez-Mendoza, Gerardo; Rubí-Castellanos, Rodrigo; Vega-Marcín, Miguel; Valencia-Pacheco, Guillermo; Torres‐Romero, Julio César; González-Herrera, Lı́zbeth

doi:10.1002/ajhb.23540

Cited by 12 publications

(8 citation statements)

References 36 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these, miR-122 is the most studied since it comprises ∼70% of the total pool of miRNAs in liver (Lagos-Quintana et al 2002;Jopling, 2012). miR-122 expression is upregulated in hepatocytes (Long et al 2019), adipose tissue (Liao et al 2018) and the blood (Frias et al 2016) of mice fed a high fat diet, as well as obese humans (Thompson et al 2017;Willeit et al 2017;Gonzalez-Arce et al 2020). Elevated circulating levels of this miRNA strongly associated with hepatic steatosis (Wang et al 2015;Long et al 2019) and risk of metabolic syndrome and type 2 diabetes (T2D) (Willeit et al 2017).…”

Section: Tissue Of Origin Of Obesity-associated Mirnasmentioning

confidence: 99%

See 1 more Smart Citation

Extracellular miRNAs as mediators of obesity‐associated disease

Brandão

Lino

Kahn

2021

The Journal of Physiology

View full text Add to dashboard Cite

Extracellular miRNAs are found in a variety of body fluids and mediate intercellular and interorgan communication, thus regulating gene expression and cellular metabolism. These miRNAs are secreted either in small vesicles/exosomes (sEV) or bound to proteins such as Argonaute and high-density lipoprotein. Both exosomal and protein-bound circulating miRNAs are altered in obesity. Although all tissues can contribute to changes in circulating miRNAs, adipose tissue itself is an important source of these miRNAs, especially those in sEVs. These are derived from both adipocytes and macrophages and participate in crosstalk between these cells, as well as peripheral tissues, including liver, skeletal muscle and pancreas, whose function may be impaired in obesity. Changes in levels of circulating miRNAs have also been linked to the beneficial effects induced by weight loss interventions, including diet, exercise and bariatric surgery, further indicating a role for these miRNAs as mediators of disease pathogenesis. Here, we review the role of circulating miRNAs in the pathophysiology of obesity and explore their potential use as biomarkers and in therapy of obesity-associated metabolic syndrome.

show abstract

Section: Tissue Of Origin Of Obesity-associated Mirnasmentioning

confidence: 99%

“…2017; Gonzalez‐Arce et al . 2020). Elevated circulating levels of this miRNA are strongly associated with hepatic steatosis (Wang et al .…”

Section: Introductionmentioning

confidence: 99%

Extracellular miRNAs as mediators of obesity‐associated disease

Brandão

Lino

Kahn

2021

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…The y-axis represents the KEGG pathways and the x-axis shows the six target genes that participate in each selected pathway percentage, triglycerides and metabolic index; and low levels of serum high-density lipid levels. 32 Some studies have also assessed the relationship between obesity-related miRNAs and physical exercise. In this context, miR-126, miR-21, miR-146a, miR-221 and miR-223 participates in molecular signalling pathways related to cellular adaptation to exercise in people with obesity.…”

Section: Discussionmentioning

confidence: 99%

“…The high expression levels of miR‐122 and miR222 conferred a 3.11‐fold increase in the risk for obesity in children with Mayan ethnicity. Moreover, the increased expression levels of these miRNAs were also associated with higher BMI, waist to height ratio (WHR), fat percentage, triglycerides and metabolic index; and low levels of serum high‐density lipid levels 32 …”

Section: Discussionmentioning

confidence: 99%

Circulating miRNAs in girls with abdominal obesity: miR‐221‐3p as a biomarker of response to weight loss interventions

et al. 2022

View full text Add to dashboard Cite

Summary Background Recent studies have associated several microRNAs (miRNAs) with childhood obesity and energy homeostasis, suggesting that an individual miRNA profile could be used as an early predictor to estimate the response to weight loss interventions in the design of precision nutrition. Objective To investigate associations between the expression of circulating adiposity‐related miRNAs and the response to a weight loss intervention. Methods A total of 51 Spanish girls (age 7–16 years) with abdominal obesity underwent 8 weeks of a multidisciplinary intervention for weight loss. Participants were stratified into two groups in accordance with changes in body mass index (BMI) standard deviation score: low‐responders (LR) and high‐responders (HR). The expression of 39 circulating miRNAs (c‐miRNAs) was evaluated in plasma of all subjects before the intervention. Results Six miRNAs were differentially expressed between LR and HR. However, after adjustment for Tanner stage, the association was maintained only for miR‐126‐3p and miR‐221‐3p with a higher expression in HR group compared to LR group. After the intervention, miR‐221‐3p expression decreased in all subjects with a significant difference in the change within groups. However, changes in miR‐126‐3p levels were not significant. The expression of miR‐221‐3p was positively correlated with body weight, BMI and waist circumference, and negatively correlated with quantitative insulin sensitivity check index. Conclusions Bioinformatic analysis evidenced that miR‐221‐3p participates in several obesity‐related pathways, and more interestingly, this miRNA targets several candidate genes to childhood obesity according to DisGeNet database. Thus, miR‐221‐3p could be used for predicting the response to a multidisciplinary intervention for weight loss in young girls.

show abstract

“…Gender-specific variations can also lead to a change in miRNA expression profiles recorded in the literature [27]. The high circulating miR-122 expression levels increase the risk of obesity, which has also been correlated with higher anthropometric or biochemical parameters, such as body mass index, waist to height ratio, fat percentage, serum high-density lipid levels, triglycerides [28]. For a complete understanding of obesity-related miRNAs, these variables should be regarded.…”

Section: Micrornas and Obesitymentioning

confidence: 99%

Micro RNAS And Potential Role as Obesity Predictors At Period Of Covid-19

Finelli¹

2021

BJSTR

View full text Add to dashboard Cite

The continued rise in obesity is a serious worry, and in many countries it has approached epidemic rates. Elevated concentrations of endocrine peptides such as leptin, insulin, and adiponectin, which are standard characteristic markers for obesity, are created by increased White Adipose Tissue (WAT) in obese people. Significant research approaches are focused at identifying variables that impact obesity directly, which could promote earlier and more precise prediction of obesity and provide therapeutic goals for obesity remediation [1]. This overall prevalence happens early in life as well. 110 million children and teenagers between the ages of 2-19 have obesity in general [1,2]. Obesity increases the susceptibility to an increased risk of complications in this demographic, with a greater number of cardio-respiratory, musculoskeletal and psychological disorders during puberty and adulthood, with an increased possibility of developing diabetes, impairment and even premature death [3,4]. The obesity-related complications are connected to the chronic inflammation in the adipose tissue that actually occurs in a low grade. In this tissue, its normal function is modified throughout obesity with changes in its cytokine development [5,6].Proteins such as IL-6, IL-8, IL-18, leptin, TNF-α, CCL2, and resistin have been correlated with pro-inflammatory conditions and the progression of obesity-related complications, among others [5,7,8]. Setting up the pathway involved in the regulation of genes correlated with this immune response at the molecular level will allow an advancement in early-stage obesity treatment in order to minimize complications in adulthood. By binding to a complementary sequence of mRNA, molecules such as microRNAs (miRNAs) regulate gene expression [6,9,10]. Mechanisms that depend on miRNAs control up to 30% of all human genes [6,11,12]. Multiple pathways are affected by miRNAs, like insulin production, immune-mediated inflammation, adipokine expression, adipogenesis, lipid metabolism and food intake control

show abstract

High expression levels of circulating microRNA‐122 and microRNA‐222 are associated with obesity in children with Mayan ethnicity

Cited by 12 publications

References 36 publications

Extracellular miRNAs as mediators of obesity‐associated disease

Extracellular miRNAs as mediators of obesity‐associated disease

Circulating miRNAs in girls with abdominal obesity: miR‐221‐3p as a biomarker of response to weight loss interventions

Micro RNAS And Potential Role as Obesity Predictors At Period Of Covid-19

Contact Info

Product

Resources

About