High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma

Kuo, H.P.; Lin, Ruey‐Jen; Hung, Jung‐Tung; Hsieh, Chung-Bao; Hung, Tsai-Hsien; Lo, Fei-Yun; Ho, Ming‐Yi; Yeh, Chau‐Ting; Huang, Yen‐Lin; Yu, John; Yu, Alice L.

doi:10.1038/s41598-017-11136-w

Cited by 34 publications

(34 citation statements)

References 56 publications

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“…78 There is evidence that altered expression of fucosyltransferase 1 and b-1,3galactosyltransferase 5 contribute to development of HCC. 79 High expression of these enzymes in HCC tissues was associated with shorter survival times of patients. 80 B3GALT5 mediates synthesis of a precursor of the SLe a antigen, which might contribute to HCC development and metastasis.…”

Section: Glycosylation Alterations In Liver Diseasesmentioning

confidence: 97%

Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases

et al. 2020

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Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions. For example, specific glycans regulate T-cell activation, structures, and functions of immunoglobulins; interactions between microbes and immune and epithelial cells; and malignant transformation in the intestine and liver. We review the effects of protein glycosylation in regulation of gastrointestinal and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors, or as targets for therapy.

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Section: Glycosylation Alterations In Liver Diseasesmentioning

confidence: 97%

Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases

et al. 2020

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“…In particular, fucosylated carbohydrates play an important role in the regulation of multiple cellular functions such as cell trafficking, immune cell development, and interaction with gut microbes and are generated through fucosylation mediated by fucosyltransferases (FUTs) [2][3][4] . Thus far, 13 FUT genes have been identified in human genome based on their acceptor specificities and protein sequences 5 . Among them, Fut1 and Fut2 genes encode galactoside 2-alpha-L-fucosyltransferase that mediates the addition of L-fucose to the terminal β-D-galactose residues of glycan via α1,2 linkage.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that FUT1 mediates diverse biologic processes by inducing angiogenesis and macrophage polarization in rheumatoid arthritis [8][9][10] , promoting keratinocyte migration 11 , and increasing cancer cell survival in breast and liver cancers 12,13 . In the ocular surface, several types of glycoproteins have been reported to be expressed on the corneal epithelium of rats, rabbits, and humans [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress

Kim

Ryu

et al. 2020

Cell Death Dis

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Fucosylation is a biological process that plays a critical role in multiple cellular functions from cell adhesion to immune regulation. Fucosyltransferases (FUTs) mediate fucosylation, and dysregulation of genes encoding FUTs is associated with various diseases. FUT1 and its fucosylated products are expressed in the ocular surface and ocular adnexa; however, the role of FUT1 in the ocular surface health and disease is yet unclear. Here, we investigated the effects of FUT1 on the ocular surface in steady-state conditions with age and under desiccating stress using a Fut1 knockout (KO) mouse model. We found that corneal epithelial defects and stromal opacity developed in Fut1 KO mice. Also, inflammatory responses in the ocular surface and Th1 cell activation in ocular draining lymph nodes (DLNs) were upregulated. Desiccating stress further aggravated Th1 cell-mediated immune responses in DLNs, lacrimal gland, and ocular surface in Fut1 KO mice, leading to severe corneal epithelial disruption and opacity. Mixed lymphocyte reaction assays revealed that the activity of splenocytes to stimulate CD4 T-cell proliferation was increased in Fut1 KO mice. Together, these data demonstrate that FUT1 deficiency induces immune dysregulation in the ocular surface and corneal opacity in steady state and under desiccating stress.

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“…Lai et al reported that Fut1 and Fut2 were upregulated in breast cancer (6)(7). High expression of Fut1 was also reported in small cell lung cancer (8), leukemia (9), ovarian cancer (10)(11), prostate cancer (12)(13) and hepatocellular carcinoma (14). Mass spectrometry analysis revealed the higher level of expression of a1,2 fucosylated structures including Globo-H in primary hepatocellular carcinoma (15).…”

Section: Introductionmentioning

confidence: 96%

Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice

Chen

Zhang³

et al. 2019

Preprint

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Abbreviations:Fut1, a-2 fucosyltransferase I; Fut2, a-2 fucosyltransferase II; Sec1, a-2 fucosyltransferase III; Blood group H, Fuc a2 Gal b; Blood group A, GalNAc a3 Fuc a2 Gal b; Blood group B, Gal a3 Fuc a2 Gal b; CFG, consortium of functional glycomics; Lewis y, Fuc a2 Gal b4 (a3) GlcNAc b; Type I H, Fuc a2 Gal b3 GlcNAc b; Type II H, Fuc a2 Gal b4 GlcNAc b; Type III H, Fuc a2 Gal b3 GalNAc a;Type IV H, Fuc a2 Gal b3 GalNAc b;Type VI H, Fuc a2 Gal b4 Glc b AbstractThe fucose alpha(1,2) galactose structure (H antigen) is synthesized by a1,2 fucosyltransferases Fut1, Fut2 and Sec1. H antigen has been reported to be involved in cancer progression, neurite migration, synaptic plasticity, host-microbe interaction, blastocyst implantation, and the maintenance of gut microbiome. Genetic depletion of Fut1 or Fut2 only cause defects of alpha1,2 fucosylation in limited tissues because of enzyme redundancy. In this study, we generated mice with deficiencies in Fut1, Fut2, and Sec1 genes to deplete H antigen through BAC Engineering for the generation of ES Cell-Targeting construct. The homogenous triple knockout mice showed no significant decrease of viability or development. Mass spectrometry and Western blot analysis confirmed the absence of H blood group antigen in multiple organs. These results indicate normal development and fertility of mice devoid of blood group H. The fine pathophysiological alterations in these mice remain to be carefully studied, and they may serve as valuable tools to study gut microbiome and host-microbe interactions.

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High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma

Cited by 34 publications

References 56 publications

Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases

Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress

Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice

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