High-efficiency antibacterial calcium alginate/lysozyme/AgNPs composite sponge for wound healing

Chen, Liang-Liang; Shi, Wen-Pu; Zhou, Ya-Qing; Zhang, Tuo-Di; Lin, Wen-Juan; Guo, Wei-Hong; Zhou, Ren-Bin; Yin, Da-Chuan

doi:10.1016/j.ijbiomac.2023.128370

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…The cylindrical hydrogels (diameter = 5 mm, height = 5 mm) were sterilized by ultraviolet radiation for 15 min before testing, and then they were placed on the surface of the solid medium and incubated with bacteria at 37°C for 24 h. The diameter of the inhibition zones was compared to verify the antibacterial effect of hydrogel. 24…”

Section: Methodsmentioning

confidence: 99%

The effect of Bletilla striata polysaccharide on the physical and healing properties of curdlan-based hydrogel for wound healing

Shang,

Duan,

Zhang

et al. 2024

J Biomater Appl

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Bletilla striata polysaccharide (BSP) was added to curdlan to form a blend hydrogel through a simple heating-cooling procedure to improve the hydrophilicity and healing efficacy of curdlan-based hydrogel used in wound healing. We explored the interplay between BSP and curdlan, studied how BSP concentration affects the physical properties and microstructures of hydrogels, and examined the biocompatibility and healing properties of the blend hydrogel. It was proved that the hydrogel framework was primarily formed by ordered arranged curdlan molecules, with BSP uniformly dispersed and intertwined with curdlan through hydrogen bonding. This effectively improved its hydrophilicity and strengthened the microstructure. Curdlan was found to be compatible with BSP. The blend hydrogel B3Cd3 (containing 1.5% BSP and 1.5% curdlan, w/v) was identified as the optimal formulation based on its higher water adsorption, water retention, thermal stability and interconnected microstructure, and was thus selected for further research. In vitro experiments revealed the highest cell viability of L929 in B3Cd3 extracts compared to those extracts of single-component curdlan hydrogel (Cd). In vivo, animal studies indicated that the B3Cd3 accelerated wound healing compared to the control group by improving re-epithelialization and blood vessel regeneration. On Days 3 and 11, the therapeutic benefits of B3Cd3 exceeded those of the Cd group, and no significant differences were observed in wound healing rates between the B and B3Cd3 groups from Day 7. The study proves that BSP enhances the physical and healing properties, as well as cell proliferation, of the curdlan-based hydrogel. The blend hydrogel B3Cd3, with its exceptional properties, holds potential for future application as a material for non-infected wound healing.

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Section: Methodsmentioning

confidence: 99%