High efficiency and flexible construction of hydrophilic polymer brushes on polyether ether ketone hollow-fiber membrane surface for improving permeability separation, and anti-fouling performances

Zhang, Shengchang; Chen, Chaofeng; Su, Zhen; Qin, Xiangpu; Jiang, Mengjin; Liu, Pengqing

doi:10.1016/j.cej.2022.140176

Cited by 14 publications

(13 citation statements)

References 57 publications

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“…Polyether imide (PEI1000, Shaber Basic Innovation Plastics) was used as a pore-forming agent. According to our previous publications, , PEEK-HFM was prepared via a combination of melt spinning and thermally induced phase separation (TIPS) method. First, 40 wt % of PEEK and 60 wt % of PEI were fabricated into hollow blended fibers at 370 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Polyether imide (PEI1000, Shaber Basic Innovation Plastics) was used as a pore-forming agent. According to our previous publications, 35,36 21−23 High-voltage mercury lamp (HB-26103BY-1, Ushio Inc., Tokyo, Japan) was used as the ultraviolet irradiation light source, and the hydrophilic components used are PEG200, AA, and MPC. In our experiments, the PEEK-HFMs were cleaned with ethanol overnight; then, each component was dissolved in water and adjusted to 0.1 mol/L.…”

Section: Methodsmentioning

confidence: 99%

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Improving the Blood Compatibility and the Gas Permeability of Polyether Ether Ketone Hollow Fiber Membrane Used for Membrane Oxygenator via Grafting Hydrophilic Components

Qin

Zhou

Zhang

et al. 2023

ACS Appl. Polym. Mater.

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As the core component of extracorporeal membrane oxygenation (ECMO) therapy for patients with severe cardiopulmonary failure, the structures and the properties of membrane oxygenator play a crucial role in determining both the efficiency of the gas exchange and the safety of the patients. Herein, with the aim of enhancing the blood compatibility, gas permeability, and durability of the membrane oxygenator, a porous polyether ether ketone hollow fiber membrane (PEEK-HFM) was prepared via a combination of melt spinning and thermally induced phase separation method. Subsequently, three different hydrophilic components including a nonionic polymer (poly(ethylene glycol), PEG), an ionic monomer (acrylic acid, AA), and a zwitterionic monomer (2-methacryloyloxyethyl phosphorylcholine, MPC) were introduced onto the PEEK-HFM surface by UVinduced grafting. The effects of different hydrophilic modifications on the surface characteristics (such as surface water wettability, surface potential, and porous morphologies) and the related properties (including mechanical performance, blood compatibility, and gas exchange permeability) were studied in detail. After grafting different hydrophilic components, not only the pore size of the corresponding PEEK-HFMs decreased compared to the unmodified PEEK-HFMs but also the surface roughness. Meanwhile, although the hydrophilic modifications resulted in the deterioration of the tensile strength of resulting PHFMs, it enhanced the blood compatibility of modified PEEK-HFMs. Moreover, among these modified membranes, the one grafted with MPC showed the best blood compatibility due to its more hydrophilic surface. Additionally, the modified membranes still maintained excellent gas permeability, ensuring the gas exchange performance between carbon dioxide and oxygen. Furthermore, a comprehensive comparison between the modified PEEK-HFMs and a commercial membrane oxygenator (poly(4-methyl-1-pentene), PMP) demonstrated that the modified PEEK-HFMs exhibited higher gas permeability, better blood compatibility, stronger gas exchange ability, and comparable tensile strength, indicating their potential as a high-efficiency option for membrane oxygenators.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Improving the Blood Compatibility and the Gas Permeability of Polyether Ether Ketone Hollow Fiber Membrane Used for Membrane Oxygenator via Grafting Hydrophilic Components

Qin

Zhou

Zhang

et al. 2023

ACS Appl. Polym. Mater.

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“…Prolonged reaction times utilizing the DMSO-based reduction protocol led to a high degree of modification and dissolution of hydroxyl-modified PEEK molecules in the DMSO solvent media. 15 In the work reported here, mild synthetic methodologies were developed to functionalize preformed porous PEEK materials with hydroxyl surface groups. The methodology was optimized toward the preservation of both the preformed porous structure and the degree of crystallinity of the porous PEEK precursors.…”

Section: Introductionmentioning

confidence: 99%

Reduction of mesoporous poly(ether ether ketone) materials, preserving pore size

Weintraub,

Gellerman,

Bazylevich

et al. 2024

Polymer International

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Polyether ether ketone (PEEK) is an important high‐performance engineering polymer that is used extensively in numerous engineering applications that require chemical, solvent, and thermal resistance. These attributes make PEEK attractive for the preparation of porous materials and membranes. Chemical modifications of preformed porous PEEK materials can expand the utilization of PEEK in a range of applications. It is desirable to carry out chemical functionalization without affecting the preformed porous structure or the degree of polymer crystallinity responsible for the sought‐after properties. We report here on the heterogeneous functionalization of preformed mesoporous PEEK materials with hydroxyl groups using sodium borohydride as a reductive agent in a PEG‐400/THF solvent mixture. The pore structure of functionalized materials was characterized, and the degree of modification with functional groups was measured as a function of reaction protocol. The methodology was applied to the preparation of porous PEEK materials in the form of beads and hollow fibers (HF) that differed in semi‐crystalline morphology and pore structure. The degree of surface modification by ‐OH groups in reduced PEEK (PEEK‐OH) porous materials was determined quantitatively by measuring the carbocation adduct concentration formed upon the dissolution of PEEK‐OH in sulfuric acid using UV–VIS spectroscopy. Bis(4‐(4‐methoxyphenoxy)phenyl)methanone was used to optimize the reaction condition protocol. The degree of crystallinity and pore structure of the functionalized articles were largely preserved following modification.This article is protected by copyright. All rights reserved.

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“…Furthermore, to meet the long-term antibiofouling demands of practical biosensing applications, various hydrophilic polymers have been developed as anticontamination materials. , However, these methods often encounter limitations, such as complex synthesis processes and poor conductivity of the modified layers, affecting electrode sensing sensitivity. In recent years, hydrogel networks composed of three-dimensional cross-linked hydrophilic polymers have garnered widespread attention for their applications in chemical and biological sensing. − Hydrogels possess a high water content, excellent flexibility, biocompatibility, and ease of synthesis.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel/MOF Dual-Modified Photoelectrochemical Biosensor for Antibiofouling and Biocompatible Dopamine Detection

Xu,

Lu,

Zhang

2024

Langmuir

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For accurate in vivo detection, nonspecific adsorption of biomacromolecules such as proteins and cells is a severe issue. The adsorption leads to electrode passivation, significantly compromising both the sensitivity and precision of sensing. Meanwhile, common antibiofouling modifications, such as polymer coatings, still grapple with issues related to biocompatibility, electrode passivation, and miniaturization. Herein, we propose a composite antibiofouling coating strategy based on zwitterionic metal−organic frameworks (Z-MOFs) and a combination of acrylamide hydrogels. On a well-designed TiO 2 /Z-MOF/hydrogel photoelectrode, we achieve highly sensitive and selective detection of dopamine in complex biological environments. The hydrogel's three-dimensional porous structure combined with unique microporous architecture of Z-MOF ensures effective sieving of interfering macromolecules while preserving efficient small molecules and electron transport. This innovative approach paves the way for constructing miniature, in vivo antibiofouling sensors for molecule monitoring in living organisms with complicated chemical environments.

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High efficiency and flexible construction of hydrophilic polymer brushes on polyether ether ketone hollow-fiber membrane surface for improving permeability separation, and anti-fouling performances

Cited by 14 publications

References 57 publications

Improving the Blood Compatibility and the Gas Permeability of Polyether Ether Ketone Hollow Fiber Membrane Used for Membrane Oxygenator via Grafting Hydrophilic Components

Improving the Blood Compatibility and the Gas Permeability of Polyether Ether Ketone Hollow Fiber Membrane Used for Membrane Oxygenator via Grafting Hydrophilic Components

Reduction of mesoporous poly(ether ether ketone) materials, preserving pore size

Hydrogel/MOF Dual-Modified Photoelectrochemical Biosensor for Antibiofouling and Biocompatible Dopamine Detection

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