High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury

Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats

“…For example, F13640, a novel and highly selective agonist of 5-HT 1A receptors, has proved a potent antinociceptive in various experimental models of acute and chronic pain (Bardin et al 2001;Colpaert et al 2002Colpaert et al , 2004. However, our present results fit with the hypothesis of a nociceptive effect due to the activation of spinal 5-HT 1A receptors.…”

Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats

“…Previous studies have shown that stimulation of spinal 5-HT 1A (Colpaert et al, 2004;Aira et al, 2010) and 5-HT 1B/1D (Kayser et al, 2002(Kayser et al, , 2011 receptors produces antiallodynic effects, whereas activation of spinal 5-HT 2 (Aira (Rahman et al, 2006;Chen et al, 2009;Wei et al, 2010;Marshall et al, 2012), 5-HT 4 and 5-HT 6 (Rocha-González, personal communication) and 5-HT 7 (Amaya-Castellanos et al, 2011) receptors instead elicits pronociceptive effects. Nevertheless, to the best of our knowledge, no study has investigated directly the role of spinal 5-HT 5A receptors in neuropathic pain models in rats.…”

“…Accordingly, our group reported that intrathecal 5-HT, the 5-HT 1 /5-HT 5 /5-HT 7 receptor agonist 5-carboxamidotryptamine (5-CT), and the 5-HT re-uptake inhibitor fluoxetine produce antinociception in several inflammatory pain models through activation of 5-HT 5A receptors based on antagonism by a selective 5-HT 5A receptor antagonist (SB-699551) (Cervantes-Durán et al, 2013;Muñoz-Islas et al, 2014). There is also evidence that spinal 5-HT 1A (Colpaert et al, 2004;Aira et al, 2010) and 5-HT 1B/1D (Kayser et al, 2002) receptors play an antinociceptive role in neuropathic pain. Thus, the present study set out to determine the participation of spinal 5-HT 1A/1B/1D and 5-HT 5A receptors in neuropathic pain in rats.…”

Redetermination of the structure of N-(2-benzoyl-4-chlorophenyl)-2- chloroacetamide, C15H11Cl2NO2

“…Benzophenone and related compounds have been reported to show antiallergic, antiinflammatory, antiasthmatic, antimalarial, anti-microbial and antianaphylactic activity [1]. 4-Aminobenzophenones have high anti-inflammatory activity [2], a benzophenyl cyano derivative acts as a vasorelaxant [3] and the piperidinyl derivative produces analgesia [4]. Certain aminothiophenes of phenylmethanone are positive allosteric regulators of the human A1 adenosine receptor [5] and biphenyl derivatives show moderate to high activity against Mycobacterium tuberculosis in in vitro studies [6].…”