High dynamic range optical coherence tomography angiography (HDR-OCTA)

Wei, Xiang; Hormel, Tristan T.; Pi, Shaohua; Guo, Yukun; Jian, Yifan; Jia, Yali

doi:10.1364/boe.10.003560

Cited by 21 publications

(17 citation statements)

References 35 publications

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“…Furthermore, the B-frame rate is limited by the frequency of the scanner (<500 Hz at large scanning angles). Instead of slowing the system to achieve the desired 3-5 ms interval [25] to detect capillary blood flow with OCTA, we recently developed a stepped bidirectional scanning pattern [26,27] that enables faster B-frame rate (up to 1 kHz at 30°). In this project, we designed an OCTA scanning pattern (Fig.…”

Section: Image Acquisition Protocolmentioning

confidence: 99%

High-speed widefield handheld swept-source OCT angiography with a VCSEL light source

Wei

et al. 2021

Preprint

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Optical coherence tomography (OCT) and OCT angiography (OCTA) enable noninvasive structural and angiographic imaging of the eye. Portable handheld OCT/OCTA systems are required for imaging patients in the supine position. Examples include infants in the neonatal intensive care unit (NICU) and operating room (OR). The speed of image acquisition plays a pivotal role in acquiring high quality OCT/OCTA images, particularly with the handheld system, since both the operator hand tremor and subject motion can cause significant motion artifacts. In addition, having a large field of view and the ability of real-time data visualization are critical elements in rapid disease screening, reducing imaging time, and detecting peripheral retinal pathologies. The arrangement of optical components is less flexible in the handheld system due to the limitation of size and weight. In this paper, we introduce a 400-kHz, 55-degree field of view handheld OCT/OCTA system that has overcome many technical challenges as a portable OCT system as well as a high-speed OCTA system. We demonstrate imaging premature infants with retinopathy of prematurity (ROP) in the NICU, and patients with incontinentia pigmenti (IP) in the OR using our handheld OCT system. Our design may have potential for improving the diagnosis of retinal diseases and help provide a practical guideline for designing a flexible and portable OCT system.

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Section: Image Acquisition Protocolmentioning

confidence: 99%

High-speed widefield handheld swept-source OCT angiography with a VCSEL light source

Wei

et al. 2021

Preprint

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“…Multimodal imaging approaches which combine Doppler OCT and OCTA are able to add this information, by adding velocimetry to the depth encoded OCTA image (93). In addition, novel high dynamic range OCTA systems are a promising extension to the technology that are sensitive to flow speeds, and are not compromised by angle issues present in Doppler OCT systems (94).…”

Section: Advantages and Disadvantages Of Octamentioning

confidence: 99%

Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

et al. 2020

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Vascular changes are increasingly recognized as important factors in the pathophysiology of neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel technology of optical coherence tomography angiography (OCTA) images the retinal and choroidal vasculature non-invasively and in a depth-resolved manner. OCTA provides an alternative quantitative measure of retinal damage, by measuring vascular density instead of structural atrophy. Preliminary results suggest OCTA is sensitive to retinal damage in early disease stages, while also having less of a “floor-effect” compared with commonly used OCT metrics, meaning it can pick up further damage in a severely atrophied retina in later stages of disease. Furthermore, it may serve as a surrogate marker for vascular pathology in the central nervous system. Data to date consistently reveal lower densities of the retinal microvasculature in both MS and neuromyelitis optica spectrum disorder (NMOSD) compared with healthy controls, even in the absence of prior optic neuritis. Exploring the timing of vascular changes relative to structural atrophy may help answer important questions about the role of hypoperfusion in the pathophysiology of neuroinflammatory disease. Finally, qualitative characteristics of retinal microvasculature may help discriminate between different neuroinflammatory disorders. There are however still issues regarding image quality and development of standardized analysis methods before OCTA can be fully incorporated into clinical practice.

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“…Currently, commercial instruments and most OCTA studies are limited in the assessment of vascular patterns and organization, without the ability to measure vascular velocity. Experimental devices have been implemented with complex algorithms that allow one to quantify the flow velocity [9,10].…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 99%

Guidelines on Optical Coherence Tomography Angiography Imaging: 2020 Focused Update

et al. 2020

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Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. In this review, we provide a discussion of the fundamental principles of OCTA and the application of this imaging modality to study the retinal and choroidal vessels. These guidelines are focused on 2020, and include updates since the 2019 publication. Importantly, we will comment on recent findings on OCTA technology with a special focus on the three-dimensional (3D) OCTA visualization.

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High dynamic range optical coherence tomography angiography (HDR-OCTA)

Cited by 21 publications

References 35 publications

High-speed widefield handheld swept-source OCT angiography with a VCSEL light source

High-speed widefield handheld swept-source OCT angiography with a VCSEL light source

Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Guidelines on Optical Coherence Tomography Angiography Imaging: 2020 Focused Update

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