High-dose zolpidem abuse in a patient with insomnia comorbid with major depressive disorder

Furihata, Ryuji; Kizuki, Jun; Yamano, Yuya; Mizoguchi, Yasuhide; Nakajima, Suguru; Nagai, Kou; Kaneko, Yoshiyuki; Yamada, Koju; Suzuki, Masahiro; Uchiyama, Makoto

doi:10.1007/s41105-019-00250-z

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Hypnotic and sedative effects by binding to GABAA to lower neural excitability, but aggravate OSA [136] Both neuroprotection (low dosage) and neurotoxicity (high dosage) [36] Mianserin Tetracyclic antidepressant and anxiolytic effects by antagonizing histamine and serotonin receptors [137,138] Delaying neuronal death on ischemic stroke animal model [139,140] Zolpidem Hypnotic by inhibiting GABA receptor [141,142] Increasing BDNF secretion and protecting the neurovascular unit in acute stroke but harmful at high doses [35]…”

Section: Bzdmentioning

confidence: 99%

Sleep Disorders in Stroke: An Update on Management

2021

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Stroke is a leading cause of disability and mortality all over the world. Due to an aging population, the incidence of stroke is rising significantly, which has led to devastating consequences for patients. In addition to traditional risk factors such as age, hypertension, hyperlipidemia, diabetes and atrial fibrillation, sleep disorders, as independent modifiable risk factors for stroke, have been highlighted increasingly. In this review, we provide an overview of common types of current sleep disturbances in cerebrovascular diseases, including insomnia, hypersomnia, breathing-related sleep disorders, and parasomnias. Moreover, evidence-based clinical therapeutic strategies and pitfalls of specific sleep disorders after stroke are discussed. We also review the neurobiological mechanisms of these treatments as well as their effects on stroke. Since depression after stroke is so prevalent and closely related to sleep disorders, treatments of post-stroke depression are also briefly mentioned in this review article.

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Section: Bzdmentioning

confidence: 99%

Sleep Disorders in Stroke: An Update on Management

2021

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“…Experimental sleep deprivation and intervention studies support a causal relationship between sleep disturbances and experiences (Tzischinsky et al, 2018). Sleep disturbance is one of many risk factors for developing psychosis, dissociation, or mania, and risk reduction should include improving sleep along with other interventions (Furihata et al, 2020). Future studies are needed to explore mechanisms associated with sleep disturbances and dissociative experiences.…”

Section: Discussionmentioning

confidence: 99%

Can We Predict Dissociative Experiences Based on Inner Speech in Nonclinical Population by Mediating Role of Sleep Disturbance?

et al. 2022

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Dissociative experiences include various experiences and behaviors that can cause people to feel disturbed and disconnected from reality. Individuals with dissociative experiences may exhibit various symptoms, particularly in their inner speech. The present study examined how we can predict dissociative experiences based on inner speech in nonclinical populations by mediating the role of sleep disturbance. In this cross-sectional study, data were collected from university students aged 18 to 40 years (N = 400). They were asked to complete online self-report questionnaires: Varieties of the Inner Speech Questionnaire, Dissociative Experiences Scale, and Pittsburgh Sleep Quality Index. Results showed that there was a relationship between dissociative experiences and sleep disturbance (r = 0.29, p < 0.001), dialogic inner speech (r = 0.39, p < 0.001), condensed inner speech (r = 0.31, p < 0.001), other people's inner speech (r = 0.46, p < 0.001), evaluative/motivational inner speech (r = 0.28, p < 0.001), and total inner speech score (r = 0.48, p < 0.001). Thus, the current study showed a significant relationship among inner speech, dissociative experiences, and sleep disturbances. Inner speech was found to predict dissociative experiences by mediating sleep disturbances in the nonclinical population. Individuals with strong dissociative experiences had high scores for inner speech and sleep disturbance. The present study highlights a new area of research and its relationship to inner speech and dissociation. Future studies could further explore this new area to validate the findings reported here and support the authors' theoretical interpretation.

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Zolpidem abuse/withdrawal

2020

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High-dose zolpidem abuse in a patient with insomnia comorbid with major depressive disorder

Cited by 3 publications

References 9 publications

Sleep Disorders in Stroke: An Update on Management

Sleep Disorders in Stroke: An Update on Management

Can We Predict Dissociative Experiences Based on Inner Speech in Nonclinical Population by Mediating Role of Sleep Disturbance?

Zolpidem abuse/withdrawal

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