High-dose vs low-dose oxytocin for labor augmentation: a systematic review

Wei, Shuqin; Luo, Zhong‐Cheng; Qi, Hui-Ping; Xu, Hairong; Fraser, William D.

doi:10.1016/j.ajog.2010.03.007

Cited by 91 publications

(58 citation statements)

References 34 publications

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“…Furthermore, in the present study, oxytocin was administered for labor stimulation in doses ranging between 1 and 2 mIU/min (starting dose) and 20 mIU/min (upper limit). A very recent systematic review of the literature has shown that low-dose oxytocin, as applied in this study, is associated with an increase in CS rate [18]. Our results further support this finding and reinforce the need for further elucidation of the causes underlying the association between low-dose oxytocin and labor arrest in older pregnant women.…”

Section: Discussionsupporting

confidence: 88%

Increased rate of cesarean section in primiparous women aged 40 years or more: a single-center study in Japan

Takahashi

Watanabe

Sugibayashi

et al. 2011

Arch Gynecol Obstet

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Section: Discussionsupporting

confidence: 88%

Increased rate of cesarean section in primiparous women aged 40 years or more: a single-center study in Japan

Takahashi

Watanabe

Sugibayashi

et al. 2011

Arch Gynecol Obstet

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“…While some authors have reported that oxytocin infusion is effective in cervical ripening and labor induction [10,11,12], a Cochrane review of 58 trials involving more than 11,000 women concluded that, although oxytocin reduced the rate of unsuccessful delivery within 24 h compared with expectant management (8.3 vs. 54%), the cesarean section rate was increased (10.4 vs. 8.9%) [13]. Furthermore, comparison with other agents revealed that oxytocin was less effective than prostaglandins at inducing labor, and the cesarean section rate was higher with oxytocin than with prostaglandins [14].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Akay

Hızlı

Yılmaz

et al. 2012

Gynecol Obstet Invest

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Aims: The aim of this study was to compare the efficacy of oxytocin and dinoprostone in achieving successful labor induction and vaginal delivery in postterm women with an unfavorable cervix. Methods: Postterm women with an uncomplicated pregnancy and a Bishop score of ≤6 were randomized to receive either dinoprostone vaginal pessary (Propess®) or low-dose oxytocin. The primary outcomes were the length of the induction-to-delivery period and the incidence of vaginal delivery. Results: A total of 144 women were available for the analysis. The overall vaginal delivery rates were 75% (54/72) for the dinoprostone group and 80.6% (58/72; p = 0.35) for the oxytocin group; the mean induction-to-vaginal delivery interval was 13.3 and 10.3 h in the dinoprostone and the oxytocin group, respectively (p = 0.003). Uterine hyperstimulation was 7.4% compared with 6.8% (p = 0.8), and abnormal fetal heart rate was 26.4% compared with 18% (p = 0.2), respectively. Conclusion: Both oxytocin and dinoprostone seem to have similar obstetric outcomes in postterm pregnancies with an unfavorable cervix, except for a significant superiority of oxytocin for delivery in a shorter period.

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“…Around the onset of labor, uterine sensitivity to oxytocin markedly increases, which is associated with both an upregulation of OXTR mRNA levels and a strong increase in the density of myometrial oxytocin receptors [6,14]. Therefore in modern obstetric practice, oxytocin is widely used to induce and augment contractions during labor [28]. Furthermore, associations between several maternal gene polymorphisms, such as tumor necrosis factor, interleukin (IL)-4, IL-1ß receptor antagonist, matrix metalloproteinase 9, ß2-adrenergic receptor, vascular endothelial growth factor and for Factor V Leiden [11] and PTB have been described.…”

Section: Discussionmentioning

confidence: 99%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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Abstract.Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04-9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

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High-dose vs low-dose oxytocin for labor augmentation: a systematic review

Cited by 91 publications

References 34 publications

Increased rate of cesarean section in primiparous women aged 40 years or more: a single-center study in Japan

Increased rate of cesarean section in primiparous women aged 40 years or more: a single-center study in Japan

Comparison of Low-Dose Oxytocin and Dinoprostone for Labor Induction in Postterm Pregnancies: A Randomized Controlled Prospective Study

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

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