High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

Tukvadze, Nestan; Sanikidze, Ekaterina; Kipiani, Maia; Hebbar, Gautam; Easley, Kirk A.; Shenvi, Neeta; Kempker, Russell R.; Frediani, Jennifer K.; Mirtskhulava, Veriko; Alvarez, Jessica A.; Lomtadze, Nino; Vashakidze, Lamara; Li, Hao; Rı́o, Carlos del; Tangpricha, Vin; Blumberg, Henry M.; Ziegler, Thomas R.

doi:10.3945/ajcn.115.113886

Cited by 108 publications

(113 citation statements)

References 29 publications

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“…Indeed, previous studies have shown an inverse correlation between 25(OH)D concentrations and LDL cholesterol with an independent effect of solar UV radiation (32 (39)(40)(41)(42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 96%

“…In the UV group, n = 58 at months 0-2, n = 53 at month 3, n = 46 at month 4, n = 42 at month 5, and n = 40 at month 6. D3, vitamin D 3 ; UV, narrow-band UV type B; 25(OH)D, 25-hydroxyvitamin D. 44 oral vitamin D would likely have a stronger effect on enterohepatic metabolism. Another plausible explanation for the disparate actions of the 2 modes of raising 25(OH)D concentrations is that UVB exposure generates bioactive molecules that, similar to vitamin D, can exert systemic effects.…”

Section: Discussionmentioning

confidence: 99%

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A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

Ponda

Liang

Kim

et al. 2017

The American Journal of Clinical Nutrition

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Design: We performed a randomized clinical trial in vitamin Ddeficient adults and compared vitamin D replenishment between subjects who received oral vitamin D 3 (n = 60) and those who received narrow-band UVB exposure (n = 58) #6 mo. Results: There was no difference in the change from baseline LDLcholesterol concentrations between oral vitamin D 3 and UVB groups (difference in median of oral vitamin D 3 minus that of UVB: 1.5 mg/dL; 95% CI: 25.0, 7.0 mg/dL). There were also no differences within groups or between groups for changes in total or HDL cholesterol or triglycerides. Transcriptional profiling of skin and blood, however, revealed significant upregulation of immune pathway signaling with oral vitamin D 3 but significant downregulation with UVB. Conclusions: Correcting vitamin D deficiency with either oral vitamin D 3 or UVB does not improve the lipid profile. Beyond cholesterol, these 2 modalities of raising 25(OH)D have disparate effects on gene transcription. This trial was registered at clinicaltrials.gov as NCT01688102.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

Ponda

Liang

Kim

et al. 2017

The American Journal of Clinical Nutrition

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“…However, studies examining the effect of vitamin supplementation on pulmonary diseases have shown diverse results. The response to tuberculosis treatment with and without vitamin D was not different (14,15). Even though low vitamin D levels was associated with impaired lung function and to an inadequate response to treatment in patients with asthma, the addition of vitamin D did not modify the progression of the disease, compared to controls (16,17).…”

mentioning

confidence: 86%

Vitamin D: the tricky hormone

Borba

2017

Arch. Endocrinol. Metab.

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Vitamin D, a pre-hormone produced in the skin under sunlight exposure, undergoes various metabolic steps until its active form, 1,25-dihydroxyvitamin D3, is formed. The intermediary form, 25-hydroxyvitamin D (25OHD), is the recommended form for monitoring vitamin D status. The presence of 1α-hydroxylase (CYP27B1) and the vitamin D receptor (VDR) in many cells indicates a possible local ability to synthesize 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, which has turned the attention of the medical community to the noncalcemic effects of vitamin D (1). In recent decades, several studies have demonstrated the association of circulating 25OHD levels with different diseases, their activity, and health conditions. A positive association was found in several disorders such as systemic lupus erythematosus (SLE) and its activity (2); chronic obstructive pulmonary disease (COPD) (3); inflammatory bowel disease (IBD) (4); systemic sclerosis; endocrine disorders; cancer; immune; cardiovascular and other chronic diseases (1,5); despite the presence of numerous positive observational studies, causation studies are lacking. A few good-quality randomized controlled studies on vitamin D supplementation in diverse disease endpoints show a modest effect on blood pressure, glycemic control, cancer, and immune response (5,6).Hypovitaminosis D is highly frequent worldwide and in Brazil, the prevalence ranges from 16% to 80% depending on the latitude and the population studied (1,7). Although low levels of vitamin D are present in different diseases, infertile women studied in the article by Lopes and cols. (8) and also by others (9) did not show lower levels compared to controls. The literature in the field is ambiguous, showing both the importance of its adequate level and the lack of effect in infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques (10,11). Interestingly, however, Lopes and cols. (8) pointed out the high prevalence of hypovitaminosis D in a young premenopausal population, which is in agreement with the low vitamin D levels described for postmenopausal and older women in Brazil. Vitamin D and its level of impact on fertility is a matter to be defined. This controversy points out the wide effect of vitamin D and the need for a better understanding of its metabolism.Nolasco and cols. (12) showed a positive effect of vitamin D on pulmonary function in healthy postmenopausal women participating in an aquatic exercise program. Low vitamin D levels were previously described in pulmonary diseases as well as their

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“…При этом ТТ-генотип был ассоциирован с более тяжелым течением заболевания по сравнению с СС-и ТС-вариантами [24]. Исследование TagI поли-морфизма гена VDR у взрослых, страдающих легочным туберкулезом, показало преобладание аллеля Т в груп-пе больных, соотношение генотипов ТТ, Тt и tt соста-вило соответственно 29, 45 и 26% [25]. При исследова-нии влияния TagI и FokI полиморфизмов на скорость очищения мокроты у больных легочным туберкулезом при введении им добавок витамина D было выявлено, что при генотипе CC TagI полиморфизма скорость очи-щения мокроты выше (р=0,02), чем при других вариан-тах генотипа данного полиморфизма.…”

Section: обзоры литературыunclassified

Significance of Gene Polymorphism of Vitamin D Receptor in Human Pathology

Бухалко¹,

Скрипченко²,

Скрипченко³

et al. 2017

Ross. vestn. perinatol. pediatr.

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Долгое время с момента открытия в 1913 г. ви-тамин D рассматривался только с точки зре-ния фосфорно-кальциевого обмена. Результаты многочисленных исследований последних лет показали, что витамин D в виде его гормональ-но-активной формы 1,25-дигидроксихолекальци-ферола или кальцитриола (1,25(ОH) 2 D) имеет ряд не связанных с костной системой эффектов. Био-логическое действие (эндокринное, аутокринное, паракринное) 1,25(ОН) 2 D реализуется путем свя-зывания с рецепторами витамина D, которые лока-лизованы в большинстве клеток и тканей организ-ма, таких как кости, почки, кишечник, иммунная система (Т-клетки, макрофаги и моноциты), ре-продуктивная система (матка, яички, яичники, предстательная железа, плацента и молочные же-лезы), эндокринная система (поджелудочная желе-за, гипофиз, щитовидная железа и надпочечники), © Коллектив авторов, 2017Адрес для корреспонденции: Бухалко Марина Александровна -аспирант отдела нейроинфекций и органической патологии нервной системы Детского научно-клинического центра инфекционных болезней у детей; старший лаборант кафедры инфекционных болезней Санкт-Петербург-ского государственного педиатрического медицинского университета Скрипченко Наталья Викторовна -засл. деятель науки РФ, д.м.н. проф., зам. директора Детского научно-клинического центра инфекционных бо-лезней у детей; зав. кафедрой инфекционных заболеваний у детей 197022 Санкт-Петербург, ул. Профессора Попова, д. 9, ORCID: 0000-0001-8927-3176 Скрипченко Елена Юрьевна -к.м.н., ст. н.с. отдела нейроинфекций и ор-ганической патологии нервной системы Детского научно-клинического центра инфекционных болезней у детей; доц. кафедры психоневрологии Санкт-Петербургского государственного педиатрического медицинского университета; зав. детским неврологическим отделением Институт мозга человека им. Н.П.Бехтеревой Имянитов Евгений Наумович -чл.-корр. РАН, д.м.н. проф., зав. кафедрой общей и молекулярной медицинской генетики Санкт-Петербургского го-сударственного педиатрического медицинского университета; зав. отделом биологии опухолевого роста НИИ онкологии им. Н.Н. Петрова 194100 Санкт-Петербург, Литовская ул., д.2 62:(6): 23-28. DOI: 10.21508/1027 62:(6): 23-28. DOI: 10.21508/ -4065-2017 The literature review presents information on the role of gene polymorphism of vitamin D receptor in human pathology. According to modern data, vitamin D is a hormone which has numerous pleiotropic effects on the human body by binding to its specific receptors (VDR). These effects can greatly determine the role of vitamin D in the occurence and the course of a number of widespread diseases of a modern man, including infectious pathology, autoimmune diseases, neuropsychiatric disorders. Special importance is currently attached to the receptor gene of vitamin D, VDR, which is characterized by a genetic polymorphism that can determine the features of implementation of the biological effects of calcitriol in the human body. The article presents the review data supporting the contribution of certain single nucleotide polymorphisms of gene VDR in the formatio...

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High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

Abstract: A high-dose vitamin D3 regimen safely corrected vitamin D deficiency but did not improve the rate of sputum Mtb clearance over 16 wk in this pulmonary tuberculosis cohort. This trial was registered at clinicaltrials.gov at NCT00918086.

Cited by 108 publications

References 29 publications

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

A randomized clinical trial in vitamin D–deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood ,

Vitamin D: the tricky hormone

Significance of Gene Polymorphism of Vitamin D Receptor in Human Pathology

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