High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescents

Abstract

Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received nine high-dose vitamin D supplements (as 50,000 IU/week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in four categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (p < .001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well as decrement in pain severity of dysmenorrhea (p < .05). High dose vitamin D supplementation can reduce the prevalence of PMS and dysmenorrhea as well as has positive effects on the physical and psychological symptoms of PMS.

Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents

“…A recent review demonstrated limited effectiveness for fenugreek, fish oil, fish oil and vitamin B1, ginger, valerian, vitamin B1, sataria, and zinc sulfate (31). Small studies indicate benefit to Omega-3 fatty acid supplementation, high-dose vitamin D supplementation, and low-fat vegetarian diet (21,32). Further research is needed to support acupuncture, acupressure, and TENS (11,33).…”

A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation

“…Biochemical factors including serum serum calcium (Ca),and phosphate (P), , fasting blood glucose (FBG), creatinie, blood urea nitrogen (BUN) and lipid profile; total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C), measured by using commercial kits (Pars Azmun, Karaj, Iran) and the BT-3000 auto-analyzer (Biotechnica, Rome, Italy). Lowdensity lipoprotein cholesterol (LDL-C) was estimated using Friedewald formula if serum TGs concentrations < 4.52 mmol/L [29][30][31]. High sensitivity C-reactive protein (Hs-CRP) was quantified using an immunoturbidimetry method, with limit of detection (LoD) 0.06 mg/L (Biosystems, Spain).…”

The Impact of Dysmenorrhea on Quality of Life Among Spanish Female University Students

“…According to a systematic review by Song et al [18], aromatherapy was found to be an effective intervention for reducing menstrual pain in dysmenorrhea. Likewise, the use of supplements has also spread as a complementary treatment for menstrual pain associated with dysmenorrhea [19].…”