High-dose transdermal nicotine replacement for tobacco cessation

Brokowski, Laurie; Chen, Jiahui; Tanner, Sara J.

doi:10.2146/ajhp130543

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…This study adds to existing research establishing the safety of combination and higher-dose NRT among patients with multiple comorbidities, 47 , 48 even if they continue to smoke. Although many participants continued to smoke while receiving high dosages of supplemental NRT, major adverse cardiovascular events were rare and appeared to have no association with the use of NRT.…”

Section: Discussionmentioning

confidence: 92%

Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease

et al. 2018

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Key Points Question Compared with standard cessation approaches, can long-term nicotine replacement therapy lead to higher rates of cessation or reductions in carcinogen exposure among smokers with chronic obstructive pulmonary disease? Findings In this randomized clinical trial of 398 smokers with chronic obstructive pulmonary disease, 23 of 197 (11.7%) receiving a standard smoking cessation intervention had quit at 12 months, compared with 24 of 197 (12.2%) receiving long-term nicotine replacement therapy. Both groups had comparable reductions in carcinogen and smoke exposure. Meaning Long-term nicotine replacement therapy provides an option for smokers with chronic obstructive pulmonary disease but does not result in greater rates of cessation or harm reduction.

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Section: Discussionmentioning

confidence: 92%

Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease

et al. 2018

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“…It is recommended that it should be used for at least 8 to 12 weeks before progressively reducing the number of tablets [12]. For people who are very dependent on nicotine, 16 to 24 sublingual tablets per day (i.e., a maximum of 302 mg tablets dispersed throughout the day) are recommended, whereas 8 to 12 tablets per day are recommended for those who have a low reliance [15]. It should be taken with caution in persons who are addicted to nicotine.…”

Section: Nicotine Sublingual Tabletmentioning

confidence: 99%

Pharmacotherapy in Tobacco Cessation: A Narrative Review

Pajai¹,

Paul²,

Reche³

2023

Cureus

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A chronic, recurring illness, known as nicotine addiction and dependence, is defined by a person's dependence on the substance up to the extent that their normal day-to-day activities are compromised in the absence of the substance. This paper will highlight first-line smoking cessation treatments, such as nicotine replacement therapy (NRT), bupropion, and varenicline, and second-line medications, such as clonidine, nortriptyline, anxiolytics, mecamylamine, naltrexone, and NicVAX (Nabi Biopharmaceuticals, Rockville, MD, USA). NRT offers many options for nicotine delivery methods, comprising nicotine gum, rapid-release gum, lozenges, transdermal patches, high-dose nicotine patches, oral inhalers, nasal sprays, electronic nicotine delivery systems (ENDS), and sublingual tablets. Pharmacotherapies for quitting tobacco should lessen withdrawal symptoms and stop nicotine's reinforcing effects without having too many side effects.

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“…Zaleca się jej stosowanie przez co najmniej 12 tygodni a po upływie tego czasu stopniowe zmniejszanie dawki [23]. Dla osób uzależnionych od palenia tytoniu w dużym stopniu zaleca się stosowanie od 16 do 24 tabletek, natomiast dla osób uzależnionych w mniejszym stopniu od 8 do 12 tabletek [24].…”

Section: Tabletka Podjęzykowaunclassified

“…Systemy transdermalne występują w różnych dawkach, standardowo dochodząc do około 20mg/dobę. Testowano również zastosowanie plastrów nikotynowych w znacznie wyższych dawkach, nie osiągnięto jednak jednoznacznych wyników, które wskazywałyby na celowość ich zastosowania jako NTZ [24].…”

Section: System Transdermalnyunclassified

Smoking cessation strategies: An in-depth analysis of nicotine replacement therapy and alternatives

Mrozek,

Hajduk,

Puchalski

et al. 2023

J Educ Health Sport

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Introduction and purpose: The primary objective of this literature review is to thoroughly investigate the topic of nicotine replacement therapy, considering the latest discoveries and detailing various forms of available nicotine substitution. Materials and methods: Literature review of PubMed and Google Scholar databases. State of Knowledge: Tobacco smoking remains one of the leading causes of premature death worldwide, accounting for millions of deaths each year. Nicotine, the addictive component of tobacco, is responsible for sustaining cigarette smoking patterns and making smoking cessation particularly challenging. Nicotine replacement therapy (NRT) is now considered one of the primary methods to help individuals quit smoking by reducing withdrawal symptoms and cravings associated with cessation. Conclusions: Over the years, extensive research has confirmed the effectiveness and safety of NRT, resulting in the development of different forms of nicotine substitution. The outcomes of using these various forms are similar and premature discontinuation by patients remains a primary reason for NRT failure. Therefore, it is crucial for each patient to select the form of NRT that meets their individual preferences. The best results are obtained by combining multiple forms of substitution simultaneously, as well as integrating them with other therapeutic methods.

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High-dose transdermal nicotine replacement for tobacco cessation

Abstract: The safety and efficacy of high-dose transdermal NRT for tobacco cessation have not been established in the medical literature.

Cited by 10 publications

References 13 publications

Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease

Effect of Long-term Nicotine Replacement Therapy vs Standard Smoking Cessation for Smokers With Chronic Lung Disease

Pharmacotherapy in Tobacco Cessation: A Narrative Review

Smoking cessation strategies: An in-depth analysis of nicotine replacement therapy and alternatives

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