“…Fourteen studies were dedicated to elderly patients [4, 5, 7, 9, 12, 24-33], and 7 studies accrued adult patients of all ages but contained information on outcome of the elderly subgroup [6, 13-16, 34, 35]. One retrospective study [3] described the outcome of thiotepa-based chemotherapy with ASCT administered to 52 elderly lymphoma patients, of whom 15 were PCNSL treated by this protocol as first-line approach. Nine of the 14 studies dedicated to elderly patients [7, 12, 25, 26, 28-32] were retrospective, and 4 were phase II studies [4, 5, 9, 27], with one of them designed as a randomized phase II study [4].…”