High-Dose Therapy and Autologous Hematopoietic Progenitor Cells Transplantation for Recurrent or Refractory Hodgkin's Lymphoma: Analysis of King Hussein Cancer Center Results and Prognostic Variables

Abdel-Rahman, Fawzi; Hussein, Ayad Ahmed; Aljamily, Mohammad; Al-Zaben, Abdulhadi; Hussein, Nilly; Addasi, Alaa

doi:10.5402/2012/249124

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…This case describes our attempt at modifying the conditioning regimen for relapsed Hodgkin's lymphoma. In the absence of the BCNU component of the BEAM (BCNU, etoposide, cytarabine, and melphalan) [ 15 , 22 ] or BEAC (BCNU, etoposide, Ara-cytarabine, and cyclophosphamide) [ 14 ], the second most important consideration was drug availability while still maintaining effectiveness. The regimen should facilitate a successful transplant, create enough space for preharvested stem cell to regrowth, repopulate, and restore hematopoietic reconstitution or engraftment.…”

Section: Discussionmentioning

confidence: 99%

The Use of Etoposide, Ara-Cytarabine, and Melphalan (EAM) Conditioning Chemotherapy in Autologous Stem Cell Transplantation (ASCT) for a Patient with Relapsed Hodgkin’s Lymphoma

Pangarsa

Naibaho

Yunarvika

et al. 2021

Case Reports in Hematology

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Up to 20–40% of patients with Hodgkin’s lymphoma will eventually relapse after treatment, among which early relapse confers a poor outcome. With salvage chemotherapy followed by autologous stem cell transplantation (ASCT), the long-term remission rate is 30%. We report our experience of using a modified-BEAM conditioning regimen without BCNU consisting of etoposide, cytarabine, and melphalan (EAM) in a patient with relapsed Hodgkin’s lymphoma. Before transplantation, the patient achieved second complete remission (CR2) using brentuximab vedotin and ESHAP (BR-ESHAP) chemotherapy. The ASCT went well without significant complications. This case demonstrated the considerable efficacy of EAM protocol as a conditioning regimen in terms of sufficient ablative capabilities, and the patient showed a successful hematopoietic engraftment. Although durability of the disease-free survival needs further observation, it had nearly 18 months of complete remission and the patient was in good performance status at the time of writing this manuscript.

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Section: Discussionmentioning

confidence: 99%

The Use of Etoposide, Ara-Cytarabine, and Melphalan (EAM) Conditioning Chemotherapy in Autologous Stem Cell Transplantation (ASCT) for a Patient with Relapsed Hodgkin’s Lymphoma

Pangarsa

Naibaho

Yunarvika

et al. 2021

Case Reports in Hematology

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“…Although many different conditioning regimens for relapsed/refractory HL and NHL have been proposed, none of them can be considered as a standard of care [8,9,10,11,12]. Different types of hICE conditioning regimens were described according to large ranges of cumulative dosages and administrations of drugs [10,29].…”

Section: Discussionmentioning

confidence: 99%

“…High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (AHCT) is an accepted treatment option for relapsed/refractory chemosensitive NHL/HL patients [3,4]. Predictive markers for post-AHCT outcome are chemosensitivity, number of chemotherapy lines before AHCT, disease status at the time of AHCT, relevant prognostic scores for histological subtypes of lymphoma, and time of relapse following first-line therapy (<12 months vs. >12 months) [5,6,7,8]. The best conditioning regimen before AHCT in patients with relapsed/refractory lymphoma is an undefined issue.…”

Section: Introductionmentioning

confidence: 99%

“…The best conditioning regimen before AHCT in patients with relapsed/refractory lymphoma is an undefined issue. Commonly used regimens in this scenario are BEAM (BCNU, etoposide, cytarabine, and melphalan) [8,9], BEAC (BCNU, etoposide, cytarabine, cyclophosphamide) [9], high-dose ICE (hICE; ifosfamide, carboplatin, and etoposide) [10], CMV (cyclophosphamide, melphalan, and etoposide) [11], CBV (cyclophosphamide, BCNU, and etoposide), combination regimens including total body irradiation (TBI) [12], and rituximab or I131-tositumomab combined with BEAM [13]. Few studies were reported comparing conditioning regimens in terms of toxicity and efficacy [9,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Finding the Optimal Conditioning Regimen for Relapsed/Refractory Lymphoma Patients Undergoing Autologous Hematopoietic Cell Transplantation: A Retrospective Comparison of BEAM and High-Dose ICE

Eşbah¹,

Tekgündüz²,

Demiriz³

et al. 2016

Tjh

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Objective:High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHCT) is a well-defined treatment modality for relapsed/refractory non-Hodgkin’s lymphoma (NHL) and Hodgkin’s lymphoma (HL). Although there are several options in terms of conditioning regimens before AHCT, no one treatment is accepted as a standard of care. This study aimed to compare different conditioning regimens for the treatment of NHL and HL. Materials and Methods:Medical records of 62 patients who had undergone AHCT following BEAM (BCNU, etoposide, cytarabine, and melphalan) and high-dose ICE (hICE; ifosfamide, carboplatin, and etoposide) conditioning regimens were analyzed retrospectively and compared in terms of efficacy and adverse effects.  Results:The study included a total of 29 and 33 patients diagnosed with relapsed/refractory NHL and HL, respectively. Patients received BEAM (n=37) or hICE (n=25) regimens for conditioning. One-year overall survival was 73±6% in all patients. One-year overall survival was 71±8% and 74±9% in the BEAM and hICE groups, respectively (p=0.86). The incidences of nausea/vomiting (grade ≥2) (84% vs. 44.7%; p=0.04) and mucositis (grade ≥2) (13% vs. 3%; p=0.002) were higher in the hICE group compared to the BEAM group. In addition, we witnessed significantly more hepatotoxicity of grade ≥2 (40% vs. 2.7%; p<0.005) and nephrotoxicity of grade ≥2 (48% vs. 2.7%; p<0.005) among patients who received hICE. Significantly more patients (n=4; 25%) in the hICE group experienced veno-occlusive disease (VOD) compared to the BEAM arm, where no patients developed VOD (p=0.01).Conclusion:There was no difference in terms of overall survival between the BEAM and hICE groups. We observed significantly more adverse effects among patients treated with hICE. The BEAM regimen seems to be superior to hICE in terms of toxicity profile with comparable efficacy in patients with relapsed/refractory NHL and HL.

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Urban Subalterns in the Arab Revolutions: Cairo and Damascus in Comparative Perspective

Ismail

2013

Comp Stud Soc Hist

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This paper investigates the role of urban subalterns both as participatory agents in the Arab revolutions and as mediating forces against revolutionary action. It argues that during revolutionary periods the positioning of subalterns as a political force should be understood in relation to their socio-spatial location in the urban political configuration. Looking at the protest movements in Cairo and Damascus, the paper examines the differentiated locations of subaltern actors in each to demonstrate how their positioning in relation to state and government has shaped their engagement in the revolutions. In Cairo, the mobilization of subaltern forces was anchored in spatialized forms of everyday interaction between popular forces and agents of government. These interactions were formative of urban subjectivities that entered into the making of “the people” as the subject of the Revolution. In Damascus, the configuration of the urban space and the Syrian regime's modes of control made it difficult for subaltern forces to mobilize on the same scale as in Cairo or to form a unified opposition. The regime instrumentalized socio-spatial fragmentation among subalterns, in effect turning some segments, as buffers for the regime, against others. In analytical terms, the paper underscores the common conceptual ground between the categories of “urban popular forces” and “urban subalterns.” This ground covers their socio-spatial positionality, their bases of action, and the factors shaping their political subjectivities.

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High-Dose Therapy and Autologous Hematopoietic Progenitor Cells Transplantation for Recurrent or Refractory Hodgkin's Lymphoma: Analysis of King Hussein Cancer Center Results and Prognostic Variables

Cited by 3 publications

References 21 publications

The Use of Etoposide, Ara-Cytarabine, and Melphalan (EAM) Conditioning Chemotherapy in Autologous Stem Cell Transplantation (ASCT) for a Patient with Relapsed Hodgkin’s Lymphoma

The Use of Etoposide, Ara-Cytarabine, and Melphalan (EAM) Conditioning Chemotherapy in Autologous Stem Cell Transplantation (ASCT) for a Patient with Relapsed Hodgkin’s Lymphoma

Finding the Optimal Conditioning Regimen for Relapsed/Refractory Lymphoma Patients Undergoing Autologous Hematopoietic Cell Transplantation: A Retrospective Comparison of BEAM and High-Dose ICE

Urban Subalterns in the Arab Revolutions: Cairo and Damascus in Comparative Perspective

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