High-Dose Tetracycline Therapy in Severe Acne

Baer, Rudolf L.; Leshaw, Steven M.; Shalita, Alan R.

doi:10.1001/archderm.1976.01630280009002

Cited by 28 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified 48 clinical trials investigating systemic tetracycline treatment efficacy in inflammatory acne, 11–58 29 trials investigating minocycline systemic treatment efficacy, 28,37,39,45,46,54,58–80 10 trials investigating doxycycline systemic treatment efficacy 8,9,20,62,68,69,81–84 and seven trials investigating lymecycline systemic treatment efficacy, 77,80,85–89 57 of which were included 8,9,12,14,16,17,19–21,23,25–38,41,42,44–52,54,56–58,62,66,69,71,72,75–81,83–88 . Trials were excluded for the following reasons: combination with other topical or systemic drug with antiacne efficacy, 18,53,55,64,68,73,74,82,89 use of obsolete drugs, 11,15,22 antibiotic treatment < 1 month prior to the study or selection of cases unresponsive to other antibiotics, 24,53,59,61,63,67,74 duplicate reports, 70 specific forms of acne (nodulocystic acne, 43,65 oil acne 40 ), cross‐over studies 13,18,39,60,63 …”

Section: Resultsmentioning

confidence: 99%

Efficacy of tetracyclines in the treatment of acne vulgaris: a review

2007

View full text Add to dashboard Cite

There is insufficient evidence to support one tetracycline rather than another in terms of efficacy. In the range of investigated dosages, the antibiotic dosage seems to have no impact on efficacy. Despite increased resistance to antibiotics, oral tetracycline formulations displayed no change in efficacy during the study period. Further studies are, however, required to determine if the anti-inflammatory properties of tetracyclines are sufficient in managing acne.

show abstract

Section: Resultsmentioning

confidence: 99%

Efficacy of tetracyclines in the treatment of acne vulgaris: a review

2007

View full text Add to dashboard Cite

show abstract

“…Dose reduction has been utilized for several decades. For example, tetracycline used to be given at a gram/day or even higher as a loading dose 8 . When control of the disease was obtained, the dose was then reduced.…”

Section: New Ideas–old Ideasmentioning

confidence: 99%

Antimicrobials in the Treatment of Acne and Rosacea

Witkowski

Parish

2003

Skinmed

View full text Add to dashboard Cite

“…Its advantages are that it is safe (AKERS et al 1975;SAUER 1976), cheap and can be taken just once daily. Dose-response data are not available for tetracycline (or other antibiotics) in acne, but severe disease may require up to 2 g/day (BAER et al 1976). For convenience the best method is to take a single dose first thing in the morning.…”

Section: Tetracyclinementioning

confidence: 99%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

PrefaceThe recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology.We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.It was because of this burgeoning interest in pharmacology of skin and its diseases, that this book came about. Indeed it is long overdue and was planned several years ago; we console ourselves with the thought that the delay may have served to help define certain principles which were then only just emerging.The book is divided into two volumes which are independent but complementary; the first being an account of the general pharmacology of skin, the second volume being more concerned with disease and drugs. The first volume is divided into two parts, the one dealing with the pharmacology of skin systems and their control and the other with autocoids in normal and inflamed skin. This second volume has three parts; the first part deals with the methods of measurement which are becoming of increasing importance both in studying the pharmacological effects of drugs and the clinical pharmacology of skin; the second deals with toxicology in its widest sense -including metabolism and percutaneous absorption; and the third is an account both of specific drugs and the drugs used for specific diseases.

show abstract

High-Dose Tetracycline Therapy in Severe Acne

Cited by 28 publications

References 18 publications

Efficacy of tetracyclines in the treatment of acne vulgaris: a review

Efficacy of tetracyclines in the treatment of acne vulgaris: a review

Antimicrobials in the Treatment of Acne and Rosacea

Pharmacology of the Skin II

Contact Info

Product

Resources

About