High Dose-Rate Intracavitary Brachytherapy for Cervical Carcinomas With Lower Vaginal Infiltration

Kazumoto, Tomoko; Kato, Shingo; Tabushi, Katsuyoshi; Kutsutani-Nakamura, Y; Mizuno, Hideyuki; Takahashi, Michiko; Shiromizu, Kenji; Saito, Yoshihiro

doi:10.1016/j.ijrobp.2007.02.014

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Another successful application of HDR brachytherapy in the breast is the mammosite procedure which involves endocavitary irradiation with the aid of a balloon positioned in the breast following partial mastectomy (Benitez, et al, 2007). Similar successes have been reported for rectal (Vuong, et al, 2007), cervical (Kazumoto, et al, 2007), and prostate (Kälkner, et al, 2007) cancer HDR brachytherapies. Despite the high level of clinical interest being expressed over HDR treatment, very few animal studies are being conducted to provide formative histopathological and radiobiological information.…”

Section: Introductionsupporting

confidence: 76%

High dose rate radiation treatment of experimental intramuscular prostate carcinoma

Skourou¹,

Hoopes²,

Gibbs-Strauss³

et al. 2009

International Journal of Radiation Biology

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Purpose The Dunning R3327-MLL is a well established transplanted tumor line, and as such it makes a desirable model for evaluative studies of therapy. In the current study, the interstitial growth characteristics as well as the response of this tumor to a single fraction of high dose rate radiation is investigated. Materials and Methods The in-vitro response to radiation of the Dunning R3327-MLL was studied via a colony forming assay using a Cs-137 irradiator. In-vitro radiosensitivity was determined on tumors implanted intramuscularly in the left gastrocnemius muscle of the rat and irradiated using an Ir-192 afterloader. Results The results demonstrate a faster growth rate when compared to the reported subcutaneous growth rates. The Dunning R3327-MLL’s radiosensitivity is comparable to that of late response tissues. The dose required to achieve a specific radiobiological response (the α:β ratio) of the in-vitro cell line is 2.4 Gy, whereas the ratio for the intramuscularly growing tumor was 0.99 Gy. Conclusions These findings signify the intramuscularly implanted Dunning R3327-MLL tumor model as a desirable model for the study of single fraction high dose rate radiation treatments.

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Section: Introductionsupporting

confidence: 76%

High dose rate radiation treatment of experimental intramuscular prostate carcinoma

Skourou¹,

Hoopes²,

Gibbs-Strauss³

et al. 2009

International Journal of Radiation Biology

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“…The placement of the vaginal cylinder after the treatment with TR to complement the dose to the distal portion of the vagina is simple, feasible and safe. In spite of eventual inconveniences of changing applicators and increased treatment time, patients presenting with uterine cervix cancer extending to the lower vaginal third may potentially benefit from this technique (10,15) .…”

Section: Discussionmentioning

confidence: 99%

“…Other authors have developed a similar study combining two gynecologic high dose-rate brachytherapy applicators: intrauterine tandem and mini-ovoids, and intrauterine tandem and vaginal cylinder (15) . The authors have reported the treatment results based on calculations performed by a homemade planning software that generates a "galaxy-shaped" isodose.…”

Section: Discussionmentioning

confidence: 99%

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina

et al. 2009

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OBJECTIVE: To evaluate an alternative brachytherapy technique for uterine cervix cancer involving the distal vagina, without increasing the risk of toxicity. MATERIALS AND METHODS: Theoretical study comparing three different high-dose rate intracavitary brachytherapy applicators: intrauterine tandem and vaginal cylinder (TC); tandem/ring applicator combined with vaginal cylinder (TR+C); and a virtual applicator combining both the tandem/ring and vaginal cylinder in a single device (TRC). Prescribed doses were 7 Gy at point A, and 5 Gy on the surface or at a 5 mm depth of the vaginal mucosa. Doses delivered to the rectum, bladder and sigmoid colon were kept below the tolerance limits. Volumes covered by the isodoses, respectively, 50% (V50), 100% (V100), 150% (V150) and 200% (V200) were compared. RESULTS: Both the combined TR+C and TRC presented a better dose distribution as compared with the TC applicator. The TR+C dose distribution was similar to the TRC dose, with V150 and V200 being about 50% higher for TR+C (within the cylinder). CONCLUSION: Combined TR+C in a two-time single application may represent an alternative therapy technique for patients affected by uterine cervix cancer involving the distal vagina.OBJETIVO: Avaliar uma alternativa de braquiterapia para tumores do colo uterino acometendo a porção distal da vagina, sem aumentar os riscos de toxicidade. MATERIAIS E MÉTODOS: Estudo teórico comparando três diferentes aplicadores de braquiterapia intracavitária de alta taxa de dose: sonda intrauterina e cilindro vaginal (SC); sonda e anel associado ao cilindro vaginal (SA+C) e um aplicador virtual com sonda, anel e cilindro vaginal em um único conjunto (SAC). Foram prescritas doses de 7 Gy no ponto A e 5 Gy na superfície ou a 5 mm de profundidade na mucosa vaginal, mantendo as doses nos pontos de reto, bexiga e sigmoide abaixo dos limites de tolerância. Foram comparados os volumes englobados pelas isodoses de 50% (V50), 100% (V100), 150% (V150) e 200% (V200), respectivamente. RESULTADOS: Tanto SA+C quanto SAC apresentaram melhor distribuição de dose quando comparados ao aplicador SC. A distribuição de dose obtida com SA+C foi semelhante à do aplicador SAC, sendo V150 e V200 cerca de 50% maiores para SA+C, todavia, dentro do cilindro. CONCLUSÃO: A utilização de SA+C em uma única aplicação em dois tempos pode ser uma alternativa de tratamento para pacientes que apresentam tumores de colo uterino com acometimento distal da vagina. Unitermos: Câncer do colo uterino; Radioterapia; Braquiterapia intracavitária; Dosimetria. Abstract ResumoGuimarães RGR, Carvalho HA, Stuart SR, Rubo RA, Seraide RM. Dosimetric evaluation of a combination of brachytherapy applicators for uterine cervix cancer with involvement of the distal vagina. Radiol Bras. 2009;42(4):209-214. 0100-3984 © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 5. Master,

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High dose rate ¹⁹²Ir versus high dose rate ⁶⁰Co brachytherapy: an overview of systematic reviews of clinical responses of gynecological cancers from 1984 to 2020

Abtahi

Gholami

Nashi

2021

Biomed. Phys. Eng. Express

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The Purpose. Radioisotope of 192Iradium (192Ir) has a half-life (74 days) and is not easily accessible in developing countries. As a result, by the time source shipment clearance and the customs paperwork are completed, a large proportion of useful activity had already been decayed away. In fact, 60Cobalt (60Co) remote afterloading systems are commercially available by many venders. As a result, it may well become an alternative source to 192Ir and conform many of these challenges. The aim of this study is that to report clinical responses of different types of gynaecological cancers treated with high dose rate (HDR) 192Ir and HDR60Co brachytherapy in order to check whether HDR 60Co could be used as an alternative brachytherapy, source to HDR 192Ir. Materials and Methods. A retrospective study of clinical responses of different types of gynaecological cancers, staged from I to IV according to recommendations of International Federation of Gynaecology and Obstetrics (FIGO), treated by brachytherapy alone, radiotherapy alone (combined brachytherapy and radiotherapy) and combined radiotherapy and chemotherapy (brachytherapy, radiotherapy and chemotherapy) between 1984 and December 2020 was conducted. The patients were treated with external beam radiotherapy 45–51 Gy boosted with HDR 192Ir and HDR 60Co afterloading brachytherapy of 18–30 Gy to point A. The results. The study scrutinized the data of 11086 patients with different types of gynaecological cancers. Most of the patients, 70 percent of them, were diagnosed with gynaecological cancers in stages II and III. For patients treated with 192Ir brachytherapy source 5-years overall survival rate (OS), local control, 2-years, 5-years and 10-years disease free survival (DFS), complications of gastro-intestine (GI) and complications of genito-urinary (GU) were 63.5%, 92%, 72.6%, 64.07%, 43.75%, 3.9% and 5.92%, but for those treated with 60Co they were 57.7%, 86.63%, 82.5%, 53.35%, 43.75%, 4.8% and 3.7%, respectively. Conclusions. The use of HDR 60Co brachytherapy has the capacity to produce overall survival rate and disease control in patients with carcinoma of the gynaecology comparable to that reported for HDR 192Ir brachytherapy. Currently, the toxicity and damage of the normal tissues and radiation-related second cancers are of a similar incidence to that of standard HDR 192Ir brachytherapy. Source exchange frequency is not a serious concern because it requires less frequency of replacement, and commissioning can be accomplished within years; hence, replacing HDR 192Ir with HDR 60Co brachytherapy achieves significant cost saving. Therefore, we recommend that 60Co source ought to be the first choice for low resource radiotherapy setting as it offers economic advantages over 192Ir and have comparable clinical outcomes to that of 192Ir source.

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High Dose-Rate Intracavitary Brachytherapy for Cervical Carcinomas With Lower Vaginal Infiltration

Cited by 3 publications

References 29 publications

High dose rate radiation treatment of experimental intramuscular prostate carcinoma

High dose rate radiation treatment of experimental intramuscular prostate carcinoma

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina

High dose rate ¹⁹²Ir versus high dose rate ⁶⁰Co brachytherapy: an overview of systematic reviews of clinical responses of gynecological cancers from 1984 to 2020

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High Dose-Rate Intracavitary Brachytherapy for Cervical Carcinomas With Lower Vaginal Infiltration

Cited by 3 publications

References 29 publications

High dose rate radiation treatment of experimental intramuscular prostate carcinoma

High dose rate radiation treatment of experimental intramuscular prostate carcinoma

Avaliação dosimétrica de uma combinação de aplicadores para braquiterapia de tumores do colo uterino com acometimento da porção distal da vagina

High dose rate 192Ir versus high dose rate 60Co brachytherapy: an overview of systematic reviews of clinical responses of gynecological cancers from 1984 to 2020

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High dose rate ¹⁹²Ir versus high dose rate ⁶⁰Co brachytherapy: an overview of systematic reviews of clinical responses of gynecological cancers from 1984 to 2020