High-Dose-Rate Interstitial Brachytherapy for the Treatment of High-Volume Locally Recurrent Endometrial Carcinoma

Huang, Kim; D’Souza, David; Patil, Nikhilesh; Leung, Eric; Murray, T.; Derrah, L.; Jewlal, E.; Stitt, Larry; Whiston, Frances; Sugimoto, Akira; McGee, Jacob; Préfontaine, Michel

doi:10.1016/j.ijrobp.2015.07.1216

Cited by 2 publications

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“…The rates of grade ≥2 lower urinary tract toxicity and lower gastrointestinal toxicity were 5.0% and 10.6% in our study, respectively. According to previous studies, grade ≥2 late complications of RT for recurrent patients are usually tolerable, with an approximate rate lower than 15% ( 21 , 23 , 27 ). It has been reported that re-irradiation might increase the risk of complication up to 15%–20% ( 12 , 28 ).…”

Section: Discussionmentioning

confidence: 96%

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Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors

et al. 2021

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ObjectiveThe role of salvage radiotherapy (RT) in the treatment for vaginal recurrence of cervical cancer in patients after prior surgery remains controversial. The aim of this study was to evaluate the efficacy and toxicity of salvage RT and explore prognostic factors associated with the survival after recurrence.MethodsPatients with cervical cancer, treated for vaginal recurrences at Peking Union Medical College Hospital between July 2011 and November 2019, were identified. All the patients underwent prior surgery for primary tumor and received salvage RT including external beam radiotherapy (EBRT), brachytherapy (BT), or both. The irradiation field and dose depended on the conditions of patients. Recurrence patterns were classified into four categories according to the site of recurrence. Prognostic factors on the overall survival (OS), progression-free survival (PFS), and local control (LC) were analyzed, and late toxicity was evaluated.ResultsA total of 141 patients were included in the analysis, with a median follow-up time of 40.8 months. The estimated 5-year OS, PFS, and LC rates were 81%, 75%, and 87%, respectively. In multivariate analysis, endovaginal recurrence and no irradiation history were favorable prognostic factors associated with OS (all p < 0.05), PFS (all p < 0.05), and LC (all p < 0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of the recurrence pattern is larger than the stage of primary tumor (0.734 vs. 0.670).ConclusionsRT was an effective treatment with tolerable toxicity for vaginal recurrences of cervical cancer in patients with prior surgery. Recurrence pattern and irradiation history were important prognostic factors.

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Section: Discussionmentioning

confidence: 96%

“…Huang et al. reported a 2-year LC rate of 60% in recurrent cervical cancer patients treated with interstitial BT ( 21 ). There were a few studies focusing on the role of salvage RT in cervical cancer patients with postoperative recurrence.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors

et al. 2021

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“…Locoregional recurrence of endometrial carcinoma is rare. With the advent of modern image guided radiation therapy, including IMRT and image-guided adaptive brachytherapy, radiotherapy has become the treatment of choice in previously not-irradiated patients with isolated vaginal recurrence or locoregional recurrence [362,363,[369][370][371][372][373][374][375][376][377][378]. Consideration should be given to remove solitary, easily accessible vaginal relapses, for better local symptom control prior to radiotherapy.…”

Section: Radiotherapy Naïve Patientsmentioning

confidence: 99%

“…Otherwise, further radiation should be considered as radical therapy with or without systemic therapy. Interstitial brachytherapy (low-dose rate or highdose rate) as sole modality of treatment or combined with EBRT can result in high local control over 1-5 years [373,374,381,382]. Other techniques like permanent seed implant or post-operative electron irradiation, protons and stereotactic body radiotherapy may be reccommended in highly selected patients [383][384][385].…”

Section: Radiotherapy Pretreated Patients With Locoregional Recurrencementioning

confidence: 99%

ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

Concin

Matías‐Guiu

Vergote

et al. 2021

Radiotherapy and Oncology

166

203

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A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and the European Society of Pathology (ESP) jointly decided to update these evidence-based guidelines and to cover new topics in order to improve the quality of care for women with endometrial carcinoma across Europe and worldwide. ESGO/ESTRO/ESP nominated an international multidisciplinary development group consisting of practicing clinicians and researchers who have demonstrated leadership and expertise in the care and research of endometrial carcinoma (27 experts across Europe). To ensure that the guidelines are evidence-based, the literature published since 2014, identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the

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High-Dose-Rate Interstitial Brachytherapy for the Treatment of High-Volume Locally Recurrent Endometrial Carcinoma

Cited by 2 publications

References 0 publications

Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors

Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors

ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

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