High-dose-rate brachytherapy with surface applicator in penile cancer

Saldi, Simonetta; Zucchetti, C.; Fulcheri, C.; Saccia, S.; Alì, Emanuele; Marani, Simona; Ingrosso, Gianluca; Aristei, Cynthia

doi:10.1016/j.brachy.2021.03.015

Cited by 3 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 13 There are few reports showing good results of BT in well-selected early cases of carcinoma penis. 12 13 14 Dee et al presented a case series of 12 patients treated by surface mold technique. 12 They used customized wrapper applicators, which were fit circumferentially and longitudinally around the penile shaft using super flap bolus material.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach

Thakur

Gupta

et al. 2022

ASJO

View full text Add to dashboard Cite

Purpose In this report we discuss an individually customized surface mold applicator technique to treat a case of early carcinoma penis. This case report is one of its kind which describes the brachytherapy treatment planning based on orthogonal X-ray technique. Material and methods T1N0 disease with squamous cell carcinoma histology involving the foreskin of penis and abutting the glans penis was treated by surface mold applicator technique. Impression of the organ was taken using alginate. Cast was prepared from the impression using Type 4 gypsum. The acrylic mold-based applicator was fabricated on the cast. The catheters were positioned and fixed on the acrylic mold. The organ is placed in the mold-based applicator and the catheters are reconstructed on two-dimensional imaging. The brachytherapy is delivered by the 18-channel high-dose rate Oncentra brachytherapy using Ir192 source. The dose given was 45 Gy in 15 fractions, twice daily more than 6 hours apart. Results Patient was reviewed after 6 weeks for follow-up and there was complete regression of the ulcer. At present, patient is on follow-up for the last 10 months and is now disease-free. Conclusion With judicious patient selection, surface mold brachytherapy is an attractive alternative to the interstitial brachytherapy. It is comfortable for the patient, is easily repeatable, and is time saving in high work load and limited resource settings. Early results with this technique are promising.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Saldi et al reported a series of 7 patients treated by customized applicators constructed using a three-dimensional printer or thermoplastic mask. 14 Dose delivered was 57 Gy in 19 fractions. All patients achieved complete remission and none developed grade 3 or grade 4 acute or late toxicities.…”

Section: Discussionmentioning

confidence: 99%

Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach

Thakur

Gupta

et al. 2022

ASJO

View full text Add to dashboard Cite

show abstract

Organ sparing treatment for penile cancer using a 3D-printed high-dose-rate brachytherapy applicator

et al. 2023

View full text Add to dashboard Cite

Design and development of additivemanufactured multi-channel brachytherapy applicators for cancer treatment

A. K.,

Saxena,

Puzhakkal

et al. 2024

Journal of Micromanufacturing

View full text Add to dashboard Cite

Additive manufacturing (AM) is emerging as an effective manufacturing technology that benefits the medical field with its ease of quickly realizing complex designs. Brachytherapy is a process to cure cancer patients through a high dose rate of gamma radiation. This work aimed at AM-based development of multi-channel vaginal and penile brachytherapy applicators for selectively treating cancer cells in a direction sideways to the applicator rather than the uniform radiation dose possible around the conventional applicator used in cancer treatment. An analytical model was proposed to predict the maximum surface temperature on applicators during Ir-192 source radiation. Also, the predicted values of multi-physics-based finite element method simulation were experimentally validated using a thermal imaging camera. Thermal imaging is a non-contact measurement that is found superior to the brachytherapy scale to position radioactive sources inside the applicator. Experimentally examined multi-channel applicator shows dosimetry advantage in effective radiation control and shows promise of curing cancerous cells with minimal effects on normal cells.

show abstract

High-dose-rate brachytherapy with surface applicator in penile cancer

Cited by 3 publications

References 23 publications

Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach

Step-by-Step Guide to Surface Mold Applicator-Based Brachytherapy in a Case of Early Carcinoma Penis: An Organ-Preserving Approach

Organ sparing treatment for penile cancer using a 3D-printed high-dose-rate brachytherapy applicator

Design and development of additivemanufactured multi-channel brachytherapy applicators for cancer treatment

Contact Info

Product

Resources

About