High-dose-rate brachytherapy as sole modality for early-stage endobronchial carcinoma

Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers

“…Apart from treatment for local stenosis, brachytherapy has the potential to increase local control and survival time when used in combination with external irradiation. Although none of the studies published so far could demonstrate a clear advantage in terms of survival in nonselected patients treated with this combined modality, there are indications that at least local control is better in patients with additional endoluminal brachytherapy [47].…”

“…Especially in carcinoma in situ or limited invasive tumours without nodal involvement, HDR brachytherapy could represent the definite treatment due to the deeper and unrestricted penetration. As with other treatment modalities, data published on intraluminal brachytherapy in early stage NSCLC are limited [41,[47][48][49][50][51].…”

Radioterapia no câncer de pulmão

“…Os resultados variam de 40 a 100% de melhora de sintomas como tosse, dispnéia, hemoptise e infecções de repetição (32)(33)(34)(35) . Como tratamento curativo, pode ser utilizada para reforço de dose da RT externa ou ainda de maneira exclusiva, em casos selecionados, iniciais, com lesão mucosa apenas (33,36) .…”

High Dose Rate Endobronchial Brachytherapy in Lung Cancer in Patients with Central Airway Obstruction

“…EBBT has been used in curative treatment of lung cancer, both in the exclusive treatment of early tumors with EBRT as overprint (boost or reirradiation) 2,3 . About the first indication, Marsiglia et al, reported a two year survival rate of 78% in 34 patients with small tumors without evidence of spread that were treated only with HDR-EBBT with a 30 Gy dose in 6 fractions 3 .Hennequin et al, in a series of 106 patients with localized tumors that were not candidates for surgery or EBRT, obtained a specific 3 and 5 years survival of 60% and 50% respectively 2 .The ABS recommended a healing (palliative) dose is 3 fractions of 5 to 7.5 Gy (total 15 -22.5Gy) when the patient already received 60 Gy pretreatment with EBRT, and 5 to 6 fractions of 5 to 7 Gy (total 25 -42 Gy) if this treatment is exclusively used 17 .…”

“…Boost EBBT to endobronchial gross tumors combined with external beam radiotherapy (EBRT) provides not only palliative but curative possibilities 2 . In small endobronchial tumors EBBT is used as definitive curative treatment 3 .EBBT is also used for non-oncologic pathologies 4,5 . The majority of non-small cell lung cancer (NSCLC)found at loco-regionally advanced stage and frequently associated with bronchial obstruction Various endoscopic techniques available today are including cryotherapy, stent, laser, photodynamic, and EBBT 6,7 .…”