High dose-rate afterloading in the treatment of cervical cancer of the uterus

Retrospective analysis was performed on 1022 patients with squamous cell carcinoma of the uterine cervix who were treated with high‐dose‐rate remote afterloading intracavitary irradiation at the National Institute of Radiological Sciences, Angawa, Chiba‐shi, Japan, from 1968 to 1982 in comparison with low‐dose‐rate intracavitary radiation therapy. The patient population consisted of 147 patients with Stage I disease, 256 patients with Stage II disease, 515 patients with Stage III disease, and 104 patients with Stage IV disease. Absolute 5‐year survival rates for Stages Ib, IIa, IIb, IIIb, IVa, and IVb disease were 88.1%, 76.9%, 67.0%, 52.2%, 24.1%, and 13.3%, respectively. The rates of severe complication of Grades 3 and 4 were 4.1% for the rectosigmoid colon, 1.2% for the bladder, and 1.1% for the small intestine. In the case of Stage I to II disease, the optimal dose from intracavitary sources was suggested to be 2900 cGy ± 200 cGy at point A, with 4 to 5 fractions of 600 to 700 cGy delivered over 4 to 5 weeks. These results suggested that high‐dose‐rate intracavitary radiation therapy provided clinical results comparable to those of a low‐dose‐rate technique.

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High-dose-rate remote afterloading intracavitary radiation therapy for cancer of the uterine cervix. A 20-year experience

Arai¹,

Nakano²,

Morita³

et al. 1992

Cancer

146

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Dosimetry of intracavitary placements for uterine and cervical carcinoma: results of orthogonal film, TLD, and CT-assisted techniques

Kapp¹,

Stuecklschweiger²,

Kapp

et al. 1992

Radiotherapy and Oncology

107

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High-dose-rate brachytherapy for carcinoma of the cervix: High tech or high risk?

Eifel¹

1992

International Journal of Radiation Oncology*Biology*Physics

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High dose-rate afterloading in the treatment of cervical cancer of the uterus

Cited by 16 publications

References 6 publications

High-dose-rate remote afterloading intracavitary radiation therapy for cancer of the uterine cervix. A 20-year experience

High-dose-rate remote afterloading intracavitary radiation therapy for cancer of the uterine cervix. A 20-year experience

Dosimetry of intracavitary placements for uterine and cervical carcinoma: results of orthogonal film, TLD, and CT-assisted techniques

High-dose-rate brachytherapy for carcinoma of the cervix: High tech or high risk?

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