High‐Dose, pulse intravenous methylprednisolone enhances fcγ receptor–mediated mononuclear phagocyte function in systemic lupus erythematosus

Abstract

The benefit of high-dose, pulse intravenous methylprednisolone (IVMP) for some patients with active lupus nephritis would appear paradoxical, since active nephritis is associated with profound abnormalities in Fcy receptor function, and several studies have demonstrated that glucocorticoids decrease monocyte Fc y receptor expression and phagocytic function. To resolve this paradox, we investigated the possibility that pulse IVMP might enhance monocyte Fcy receptor function in patients with systemic lupus erythematosus (SLE). Circulating immune complex (CIC) levels, Fcy receptor-mediated clearance, and Fc y receptor-dependent monocyte function were analyzed in 23 SLE patients before and after pulse IVMP (1 gm daily for 3 days). A biphasic response in CIC levels, determined by a staphylococcal protein A binding assay, was observed. Initially, CIC levels increased within 2-4 hours after the first dose of pulse IVMP and then decreased by 50% within 24-48 hours after the completion of therapy. Fcy

Antiendotoxin immune response and its relationship to the total immunity and inflammation in patients with systemic lupus erythematosus I and II degree of activity

“…При этом нормализация экспрессии LPS-FITC и увеличение специфических антител приводит к снижению лабораторных признаков воспалительного процесса. Так же в пользу протекторного вли- При изучении литературных источников, был обнаружен ряд научных исследований, где описывалось, что ГКС не имеют прямого влияния на фагоцитарную функцию лейкоцитов [23], в том числе и назначение высоких доз ГКС при пульстерапии у больных СКВ [24,25]. В исследовании G. Umberto Meduri и соавт.…”

Infections in Patients with Systemic Lupus Erythematosus: The Contribution of Primary Immune Defects Versus Treatment-Induced Immunosuppression

“…Consequently, patients receiving therapy may demonstrate enhanced neutrophil migration and phagocytic function in contrast to untreated SLE patients. 91 The risk of infection in SLE can vary according to the type of immunosuppression used. We will review studies investigating drugs used to treat patients with SLE and studies attempting to introduce new biologics and small drugs.…”

Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side

“…Corticosteroids also act on many target cells involved in innate or adaptive immunity [ 46 ]: macrophages, dendritic cells, polymorphonuclear cells, and T and B lymphocytes in particular.…”