High-Dose Oral Amoxicillin Plus Probenecid Is Highly Effective for Syphilis in Patients With HIV Infection

Abstract

The combination of oral amoxicillin 3 g plus probenecid was highly effective and tolerable for the treatment of syphilis in patients with HIV-1 infection.

Prognosis of ocular syphilis in patients infected with HIV in the antiretroviral therapy era

“…Fifteen patients (75%) were treated with intravenous benzylpenicillin (24 MU per day) with or without other medications, such as oral amoxicillin plus probenecid before or after intravenous benzylpenicillin 16. Five patients (25%) did not receive intravenous benzylpenicillin.…”

“…Serological success of syphilis treatment was defined as at least fourfold decrement in RPR titre within 24 months after initiation of treatment 16. Follow-up serum RPR titre was examined at the discretion of the attending physician.…”

“…At our clinic, written informed consent is obtained from each patient to store serum samples at the first and subsequent visits. Based on this, the RPR data from the stored samples were also used to supplement the RPR data from daily clinical practice in order to determine the response to treatment 16. Recurrence of ocular syphilis was defined as repeated episodes of ophthalmologic findings separated by periods of inactivity without treatment for at least 3 months 9…”

Amoxicillin and Ceftriaxone as Treatment Alternatives to Penicillin for Maternal Syphilis

“…A pharmacokinetic study reported that oral amoxicillin and probenecid could attain treponemicidal concentrations in cerebrospinal fluid; therefore, these drugs were considered alternative agents for treatment of neurosyphilis ( 7 ). Tanizaki et al ( 8 ) reported that treatment with oral amoxicillin (3 g) and probenecid (750 mg) was highly effective in and well tolerated by syphilis patients with HIV infection. However, in their report, all patients were men.…”

The growing epidemic of sexually transmitted infections in adolescents: a neglected population

“…While syphilis rates are at their highest in 20 years, penicillin benzathine G has become unavailable in many hospitals [41]. In Japan, amoxicillin has been successfully used as an alternative to penicillin benzathine G to treat syphilis infection and prevent mother-to-child transmission [42, 43]. …”