High dose of aspirin moderates diabetes-induced changes of heart glycogen/glucose metabolism in rats

Abstract

Aspirin (ASA), as a multifunctional drug has been used as a hypoglycaemic agent in the treatment of diabetes and severe hyperglycaemia and has been established as a secondary strategy which may prevent many cardiovascular events. In this study we investigated high dose (100 mg/kg b.w./i.p) and time-dependent (2, 7 and 14 days) effects of ASA on the heart key enzymes and substrates from glycogen/glucose metabolism in control and diabetic rats. The results accomplished demonstrated that ASA significantly potentiates glycogen accumulation, as well as decreased blood glucose level and heart glycolytic potential in control rats. The treatment of diabetic rats with ASA caused moderation of the diabetic complication-significant inhibition of glycogen accumulation, lowering of blood glucose, as well as elevation of glycolytic potential. In conclusion, we propose that use of high-dose of ASA has anabolic effects in control rats and reduces heart glycogen glucose complications in diabetic rats. The moderation of diabetes-induced changes is time-dependent and involves reduction of glycogenogenesis and inhibited depression of glycolysis, with a tendency to maintenance control values.

Tissue-Specific Metabolic Response of Acanthopanax Senticosus (Rupr. Et. Maxim.) Harms Leaf To UV-B radiation

“…In our results, the accumulation of kaempferol and rutin increased signi cantly after UV-B treatment, especially under moderate radiation, suggesting that they are the main ultraviolet absorbing substances. Salicylic acid (C6C1-type), a compound that reduces the risk of long-term heart disease in diabetic patients, increases signi cantly in A. senticosus plants when exposed to moderate UV-B radiation (Farthing et al 2007;Nulton-Persson et al 2004;Eisen et al 2009;Dervisevik et al 2014). Therefore, it can be inferred that an appropriate amount of UV-B radiation application to the plant may improve the medicinal effect of A. senticosus extract, with relation to heart disease and diabetes.…”

Comparison of the Neuroprotective Effects of Aspirin, Atorvastatin, Captopril and Metformin in Diabetes Mellitus

“…This suggests that aspirin alone has no positive effect on lipid profile improvement. However, some recent studies reported that high-dose aspirin influences lipid metabolism [26,27].…”

Aspirin suppresses colorectal cancer initiation in populations without cardiovascular disease by inhibiting cell glycolysis

“…Aspirin is a commonly used medication to prevent cardiovascular disease, which has been identified as an inhibitor of glycolysis. Dervisevik et al [3] reported that aspirin impaired glycolysis in diabetic rat heart as a result of decreased phosphofructokinase (PFK) activity. In addition, aspirin was suggested to attenuate glycolysis in HCT-116 colon cancer cells by acetylation of glycolytic pathway enzymes [4].…”