High-dose methylprednisolone pulse therapy upregulated FcγRIIb expression on B cells in primary Sjögren’s syndrome patients with thrombocytopenia

Chen, Haifeng; Zhou, Shiliang; Su, Dinglei; Lu, Liwei; Li, Xia; Sun, Lingyun

doi:10.1007/s10067-013-2344-x

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…Chen et al pointed out that the expression of FcγRIIb on B cells was significantly decreased in patients with pSS with severe thrombocytopenia. After high-dose of hormone treatment, the expression of FcγRIIb on memory B cells was up-regulated, and the platelet count was significantly increased (16). Those studies are suggestive of a role of the humoral immune response in platelet destruction which may occur in pSS.…”

Section: Discussionmentioning

confidence: 79%

Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's Syndrome

Yang

Rao

et al. 2020

Front. Med.

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Objective: Clinical characteristics of immune thrombocytopenia (ITP) associated with primary Sjögren's syndrome (pSS) have not been clearly defined. This study aimed to evaluate the prevalence and clinical characteristics of secondary ITP in patients with pSS. Methods: 291 pSS patients in our hospital were retrospectively analyzed. Clinical manifestations and laboratory findings were compared between pSS patients with and without ITP. Results: The prevalence of secondary ITP in pSS patients was 12.03%. Compared to pSS patients without ITP, pSS patients with ITP were younger and had higher disease activity. The prevalence of interstitial lung diseases (ILD) was significantly lower in pSS patients with ITP (30.43 vs. 54.95%; P = 0.029), and it was the same with arthritis (17.14 vs. 3.9.11%; P = 0.014) and dry eye (33.33 vs. 54.17%, P = 0.027) compared with those without ITP. Serum creatinine level was lower in pSS patients with ITP (P = 0.009), while positivity of anti-histone autoantibodies was higher in pSS patients with ITP (P = 0.025). Conclusion: This study is an initial report describing clinical features of ITP in pSS. The lower incidence of ILD and arthritis among pSS patients with ITP indicated potential active roles of platelets in the pathogenesis of fibrosis or inflammatory arthritis, which may open the way for further experimental and clinical work.

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Section: Discussionmentioning

confidence: 79%

Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's Syndrome

Yang

Rao

et al. 2020

Front. Med.

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“…The mechanisms of SS with thrombocytopenia is not clear. A few studies have shown that may be a complex immune pathology relating multiple factors，such as P-selectin ( 21), TLR7 signaling pathway (22) and FcγRIIb on B cells (23).…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory features of primary Sjögren’s syndrome complicated with mild to severe thrombocytopenia

Wu¹,

Chang²,

Zhang³

et al. 2022

Ann Transl Med

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Background: Patients with thrombocytopenia accompanied by positive Ro/SS-A and/or La/SS-B autoantibodies have a possible diagnosis of Sjögren's syndrome (SS). Owing to its low prevalence, large-sample controlled studies on thrombocytopenia in primary SS (pSS) are scarce. Thus, this study aimed to investigate the clinical and laboratory characteristics of pSS complicated with mild to severe thrombocytopenia, and compared them with pSS patients without thrombocytopenia. Methods: This medical records review study analyzed the demographic data, clinical manifestations, laboratory examinations, and other results of 88 patients diagnosed with pSS between March 2007 and March 2018 in the

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“…These phenomena are noteworthy. Platelet destruction is often implicated in autoimmune disease, and elevated P-selectin autoantibodies and FcγRIIb suppression on B cells may promote thrombocytopenia in pSS patients [ 23 , 24 ]. Our study suggests that ILD reduces the possibility of thrombocytopenia in SS patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical profiles of SS-ILD compared with SS-NILD in a Chinese population: a retrospective analysis of 735 patients

et al. 2021

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Background Interstitial lung disease (ILD) is a serious complication in patients with Sjögren’s syndrome (SS). Most studies on primary SS (pSS) with ILD are limited in sample size, and studies on secondary SS (sSS) with ILD are rare. This study aimed to elucidate both primary and secondary SS-associated ILD (SS-ILD) based on a large cohort. Methods The medical records of hospitalized patients diagnosed with SS at the Second Xiangya Hospital of Central South University from January 2010 to May 2020 were retrospectively reviewed. Clinical manifestations, medical history, biological results and imaging data were collected. Results Of the 735 SS patients enrolled in this study, 563 (76.6%) were diagnosed with pSS, 172 (23.4%) were diagnosed with sSS. Additionally, 316 (43.0%) were diagnosed with SS-ILD. No significant difference was found between the pSS and sSS groups concerning the incidence of ILD ( p = .718). Factors associated with SS-ILD were older age ( p < .001), male sex ( p = .032), female sex at menopause ( p = .002), Raynaud’s phenomenon ( p < .001), low levels of albumin ( p = .010) and respiratory symptoms ( p < .001). The SS-ILD group showed higher counts of platelets ( p < .001). The three most frequent high-resolution CT (HRCT) findings of SS-ILD were irregular linear opacities (42.7%), grid shadows (30.7%) and pleural thickening (28.5%). NSIP (56.3%) was the most frequent HRCT pattern. Compared with pSS patients with ILD (pSS-ILD) patients, sSS patients with ILD (sSS-ILD) patients had a higher incidence of proteinuria ( p < .001) and hypercreatinaemia ( p = .013), a higher level of erythrocyte sedimentation rate (ESR) ( p = .003), low levels of complement 3 (C3) ( p = .013), lymphocytes ( p = .009) and leukocytes ( p = .024), and worse DLCO (%Pred) ( p = .035). Conclusions ILD is a common pulmonary involvement in both pSS patients and sSS patients. Older age, male sex, female sex at menopause, Raynaud’s phenomenon, low albumin levels and respiratory symptoms are risk factors associated with SS-ILD. NSIP is important HRCT feature of SS-ILD. sSS-ILD patients showed worse laboratory results and pulmonary function. KEY MESSAGE Older age, male sex, female sex at menopause, Raynaud’s phenomenon, low albumin levels and respiratory symptoms are risk factors associated with SS-ILD. SS-ILD patients show higher counts of platelets and less purpura. sSS-ILD patients have worse laboratory results and pulmonary functi...

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High-dose methylprednisolone pulse therapy upregulated FcγRIIb expression on B cells in primary Sjögren’s syndrome patients with thrombocytopenia

Cited by 7 publications

References 28 publications

Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's Syndrome

Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's Syndrome

Clinical and laboratory features of primary Sjögren’s syndrome complicated with mild to severe thrombocytopenia

Clinical profiles of SS-ILD compared with SS-NILD in a Chinese population: a retrospective analysis of 735 patients

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