High-dose intravenous iron supplementation after preoperative autologous blood donation is useful to prevent post-donation/preoperative anemia

Investigation on the feasibility of large‐volume autologous red blood cells donation: A pilot trial in a small cohort of Chinese

“…17 It suggests that on the basis of stimulating the erythropoiesis capacity by the large-volume RBC donation, intravenous iron supplementation can improve the recovery of RBC in the relatively short period without the low absorption rate and low medication compliance of oral iron supplementation. 36 The levels of serum iron, serum ferritin, and transferrin saturation increased during the first week because of the supplement of intravenous iron, and then gradually decreased and approached to the baseline at the end of the study period. It was proved that intravenous iron supplementation not only guaranteed the rapid erythropoiesis but also maintained the stability of iron until the end of the study.…”

“…Therefore, it is necessary to avoid the suppression of RBC production caused by iron deficiency after blood donation. Compared with oral iron supplementation that takes more time for RBC recovery after donation, high‐dose IV iron supplementation after PAD will be useful in the treatment of post‐donation anemia 36,37 …”

“…However, Höcker calculated the median net profit of red cells with only 140 mL obtained after 2‐unit autologous RBC (310 mL) apheresis and oral iron supplementation within 3 weeks 17 . It suggests that on the basis of stimulating the erythropoiesis capacity by the large‐volume RBC donation, intravenous iron supplementation can improve the recovery of RBC in the relatively short period without the low absorption rate and low medication compliance of oral iron supplementation 36 …”

“…Compared with oral iron supplementation that takes more time for RBC recovery after donation, high-dose IV iron supplementation after PAD will be useful in the treatment of post-donation anemia. 36,37 In order to prevent iron deficiency affecting the recovery of Hb, 800 mg of iron sucrose was intermittently given within 8 days after donation in our study. We observed the overall changes of RBC, Hb concentration, Hct, Epo, and reticulocyte count after large-volume RBC apheresis without being affected by iron deficiency.…”