High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis

Abstract

23. Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI): experimental models.

Intravenous Immunoglobulin-Induced Neutrophil Apoptosis in the Lung during Murine Endotoxemia

“…The reported anti-inflammatory effects of IVIg have indicated that it reduced serum or plasma cytokine concentrations in vivo [8,12,13] IVIg therapy requires high doses (1,000-2,000 mg/kg) of IVIg because a minor population of IgG crystallizable fragments (Fcs) with glycans terminating in a2,6 sialic acids (sFc) is an important factor in anti-inflammatory effects [14,15]. The sFc target is composed of myeloid regulatory cells expressing the lectin dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN).…”

“…A recent clinical study showed that septic shock patients with low-IgG concentrations have a higher tendency to develop ARDS associated with higher mortality [7]. Hagiwara et al reported that administration of high-dose (1,000 mg/kg) IVIg reduced mortality and improved pulmonary pathology in a rat sepsis model via reduction of high mobility group box protein 1 (HMGB1) [8]. Takeshita et al reported that IVIg induced LPS-stimulated neutrophil apoptosis in vitro [9].…”

High-mobility-group box chromosomal protein 1 as a new target for modulating stress response

“…119 Several other commercially available drugs, such as sivelestat, nafamostat, antithrombin III, and γ-globulin, have also been suggested to modulate infl ammatory response through HMGB1-related mechanisms. [120][121][122][123][124] Others It has been suggested that direct hemoperfusion using a polymyxin B-immobilized fi ber column reduces HMGB1 levels in septic patients. 125…”

Alternate Day Calorie Restriction Improves Systemic Inflammation in a Mouse Model of Sepsis Induced by Cecal Ligation and Puncture

“…All mice were weighed before random assignment to one of four 8-d treatments: calorie restriction every other day for a total of four times followed by CLP (ACRþCLP group), normal feeding followed by CLP (CLP group), normal feeding followed by abdominal surgery without cecal ligation and puncture (control group), calorie restriction every other day for a total of four times without cecal ligation and puncture (ACR group). After anesthesia was induced by 5% sevoflurane, CLP was performed as previously described [14]. Briefly, the cecum was ligated below the ileocecal valve and punctured with a 21-gauge needle.…”