High dose hypofractionated frameless volumetric modulated arc radiotherapy is a feasible method for treating canine trigeminal nerve sheath tumors

Dolera, Mario; Malfassi, Luca; Marcarini, Silvia; Mazza, G.; Carrara, Nancy; Pavesi, Simone; Sala, Massimo; Finesso, Sara; Urso, Gaetano

doi:10.1111/vru.12637

Cited by 8 publications

(10 citation statements)

References 32 publications

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“…Observed clinical signs, neurological deficits, and MRI findings were similar to those previously reported . Although recent studies have focused on clinical outcomes after advanced treatment strategies, including stereotactic radiotherapy and volumetric‐modulated arc radiotherapy, the natural progression and survival of dogs with TNST after conservative treatment has rarely been reported. Although 2 of 27 dogs in which treatment was attempted underwent radiotherapy, the remaining 25 dogs included in our study received conservative medical treatment or no specific treatment at all.…”

Section: Discussionsupporting

confidence: 81%

Clinical findings and outcome of dogs with unilateral masticatory muscle atrophy

Milodowski

Amengual-Batle

Beltrán

et al. 2018

Veterinary Internal Medicne

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Background Little is known about the spectrum of underlying disorders in dogs with unilateral masticatory muscle (MM) atrophy. Objectives To evaluate the clinical presentation, magnetic resonance imaging (MRI) findings, and outcome of dogs with unilateral MM atrophy. Animals Sixty‐three client‐owned dogs. Methods The medical database was retrospectively reviewed for dogs that underwent MRI for evaluation of unilateral MM atrophy. Imaging studies were reviewed and follow‐up information was obtained from telephone interviews. Results Presumptive trigeminal nerve sheath tumor (pTNST) was diagnosed in 30 dogs (47.6%); survival time varied from 1 day to 21 months (median, 5 months). Other extra‐axial mass lesions were observed in 13 dogs (20.6%); survival time varied from 6 days to 25 months (median, 2.5 months). In 18 dogs (28.6%), no abnormalities were observed on MRI; neurological signs only progressed in 1 dog. Diagnosis had a significant influence on the type of neurological abnormalities, with additional neurological deficits observed in most dogs with pTNST and in all dogs with other extra‐axial mass lesions. Diagnosis had a significant effect on euthanasia at the time of diagnosis and likelihood of neurological deterioration. Dogs with mass lesions were more likely to be euthanized or experience neurological deterioration, whereas these outcomes occurred less often in dogs in which no causative lesion could be identified. Conclusions and Clinical Importance Trigeminal nerve sheath tumors should not be considered the only cause of unilateral MM atrophy. Our results illustrate the importance of performing a neurological examination and MRI when evaluating dogs with unilateral MM atrophy.

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Section: Discussionsupporting

confidence: 81%

Clinical findings and outcome of dogs with unilateral masticatory muscle atrophy

Milodowski

Amengual-Batle

Beltrán

et al. 2018

Veterinary Internal Medicne

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“…It is now possible to perform irradiation at a dose rate higher than 400 cGy/min using a linac. However, we considered our dose rate more appropriate, since the intensity‐modulated radiation therapy creates a very complicated irradiation field and takes more time to deliver the dosage to the target (with the effective dose rate of around 200 cGy/min or less, depending on the degree of modulation and complexity of the plan) . Furthermore, increment of dose rate 200 to 400 cGy affects only less than 1% for cellular survival fraction.…”

Section: Discussionmentioning

confidence: 99%

Analysis of radiosensitivity of cancer stem‐like cells derived from canine cancer cell lines

Deguchi

Hosoya

Murase

et al. 2019

Vet Comparative Oncology

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Cancer stem‐like cells (CSCs) are self‐renewing cells comprising a small subpopulation in tumours, and generate differentiated progeny through asymmetric division. It has been shown that CSCs are resistant to ionizing radiation, and this feature could be one of the mechanisms of tumour recurrence after radiation therapy. Much attention has been focused on to target CSCs; however, difficult of isolating CSCs and lack of knowledge on their radiosensitivity have limited this kind of research in veterinary medicine. In the present study, sphere‐forming cells (SC), cultured using sphere formation method, were isolated from four type of canine tumour cell lines and evaluated if they have CSCs‐like properties by expression of CSCs markers (real‐time polymerase chain reaction) and capacity of tumorigenesis (xenograft transplantation in nude mice), and were assessed radiosensitivity (clonogenic survival assay) and DNA repair kinetics (immunofluorescence staining for p53‐binding protein 1) after X‐ray irradiation in comparison with the corresponding normal adherent culture cells (AC). All SCs were isolated using sphere formation and showed high gene expression of CD133 and tumorigenic ability as compared with AC. All SCs were significantly resistant against X‐ray irradiation as compared with AC. In addition, the amount of DNA double‐strand breaks after X‐ray irradiation were significantly lower in SC compared with the corresponding AC. These results indicate that SC isolated through sphere formation possess CSCs‐like characteristics and CSCs are important factor that affect radiosensitivity in canine tumours. In addition, radioresistance of CSCs may depend on reaction of DNA double‐strand break after X‐ray exposure.

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“…There is little documentation of pseudoprogression in the veterinary literature. In one small study investigating the feasibility and effectiveness of curative intent high‐dose hypofractionated frameless volumetric modulated arc radiotherapy for treatment of canine trigeminal peripheral nerve sheath tumours, one of the seven dogs enrolled experienced possible pseudoprogression with transient increase in tumour size despite substantial clinical improvement 10. To the authors’ knowledge, this is the only documented case of suspect pseudoprogression in the veterinary literature.…”

Section: Discussionmentioning

confidence: 97%

Unexpected but transient tumour enlargement preceded complete regression and long‐term control after irradiation of squamous cell carcinoma in a red‐eared slider (Trachemys scripta elegans)

Baja¹,

Lewbart²,

Luff

et al. 2020

Vet Record Case Reports

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A red-eared slider with a chronic non-healing ulcerative shell lesion was diagnosed with cutaneous squamous cell carcinoma (SCC). The animal underwent surgical debulking and adjuvant hypofractionated radiation therapy. The lesion initially responded, with near-complete tumour regression, but then began growing again just a few months after finishing radiotherapy. Then, after several months with no additional tumour-directed therapy, the lesion again regressed. Five years post-irradiation and with no further treatment, the turtle now remains tumour-free. This unusual pattern of disease regression, followed by transient growth and then long-term local tumour control, suggests either a spontaneous remission or a pseudoprogression-like phenomenon. Careful clinical follow-up and reporting of future cases will aid in determining whether this pseudoprogression-like event was random, versus being a common component of the chelonian response to irradiation of cutaneous SCC.

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High dose hypofractionated frameless volumetric modulated arc radiotherapy is a feasible method for treating canine trigeminal nerve sheath tumors

Cited by 8 publications

References 32 publications

Clinical findings and outcome of dogs with unilateral masticatory muscle atrophy

Clinical findings and outcome of dogs with unilateral masticatory muscle atrophy

Analysis of radiosensitivity of cancer stem‐like cells derived from canine cancer cell lines

Unexpected but transient tumour enlargement preceded complete regression and long‐term control after irradiation of squamous cell carcinoma in a red‐eared slider (Trachemys scripta elegans)

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