High-dose erythropoietin inhibits apoptosis and stimulates proliferation in neonatal rat intestine

McPherson, Ronald J.; Juul, Sandra E.

doi:10.1016/j.ghir.2007.05.006

Cited by 28 publications

(21 citation statements)

References 50 publications

(51 reference statements)

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“…Although no consensus exists for optimal EPO dosage, timing, and frequency, EPO has been shown to have beneficial effects when used with several different treatment strategies (3,15). Consistent with these studies, the authors of this study demonstrated EPO neuroprotection at a dosage 5 kU/kg, but not 20 kU/kg.…”

supporting

confidence: 69%

Is Erythropoietin the Answer?: Commentary on the article by Fan et al. on page 56

2011

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supporting

confidence: 69%

Is Erythropoietin the Answer?: Commentary on the article by Fan et al. on page 56

2011

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“…With respect to the digestive tract, cells in the gastric mucosa [58] and enterocytes in the fetal and neonatal small intestine of the rat [59,60] express EPO-R.…”

Section: Epo and Epo-r Expression In Nonerythroid Tissuesmentioning

confidence: 99%

“…McPherson and Juul [60] reported that EPO affects the development of rat intestine wherein it (a) promotes the division of intestinal smooth muscle cells and enterocytes and (b) stimulates the migration of intestinal epithelial cells and prevents their apoptosis.…”

Section: Other Actions Of Epomentioning

confidence: 99%

Erythropoietin: A Hormone with Multiple Functions

2011

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Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion of EPO and the expression of its receptor (EPO-R) are regulated by tissue oxygenation. EPO and EPO-R, expressed in several tissues, exert pleiotropic activities and have different effects on nonhemopoietic cells. EPO is a cytokine with antiapoptotic activity and plays a potential neuroprotective and cardioprotective role against ischemia. EPO is also involved in angiogenesis, neurogenesis, and the immune response. EPO can prevent metabolic alterations, neuronal and vascular degeneration, and inflammatory cell activation. Consequently, EPO may be of therapeutic use for a variety of disorders. Many tumors express EPO and/or EPO-R, but the action of EPO on tumor cells remains controversial. It has been suggested that EPO promotes the proliferation and survival of cancer cells expressing EPO-R. On the other hand, other reports have concluded that EPO-R plays no role in tumor progression. This review provides a detailed insight into the nonhemopoietic role of EPO and its mechanism(s) of action which may lead to a better understanding of its potential therapeutic value in diverse clinical settings.

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“…Inhibition of STAT5b suppresses proliferation of human glioblastoma multiforme cells, and thus, it may serve as a therapeutic target (Liang et al, 2009). It can be activated by erythropoietin and thus mediates proliferation signaling (McPherson and Juul, 2007).…”

Section: Discussionmentioning

confidence: 99%

Analysis of key genes and modules during the courses of traumatic brain injury with microarray technology

Xy¹,

Cg²,

Gu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Gene expression data acquired at different times after traumatic brain injury (TBI) were analyzed to identify differentially expressed genes (DEGs). Interaction network analysis and functional enrichment analysis were performed to extract valuable information, which may benefit diagnosis and treatment of TBI. Microarray data were downloaded from Gene Expression Omnibus and pre-treated with MATLAB. DEGs were screened out with the SAM method. Interaction networks of the DEGs were established, followed by module analysis and functional enrichment analysis to obtain insight into the molecular mechanisms. A total of 39 samples at six time points (30 min, 4, 8, 24 , 72 h, and 21 days) were analyzed and generated 377 DEGs. Eight modules 9221 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 9220-9228 (2014) Biomarker screening for traumatic brain injury were identified from the networks and network ontology analysis revealed that cell surface receptor-linked signaling pathway, response to wounding and signaling pathway were significantly overrepresented. Altered risk genes and modules in TBI were uncovered through comparing the gene expression data acquired at various time points. These genes or modules could be potential biomarkers for diagnosis and treatment of TBI.

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High-dose erythropoietin inhibits apoptosis and stimulates proliferation in neonatal rat intestine

Cited by 28 publications

References 50 publications

Is Erythropoietin the Answer?: Commentary on the article by Fan et al. on page 56

Is Erythropoietin the Answer?: Commentary on the article by Fan et al. on page 56

Erythropoietin: A Hormone with Multiple Functions

Analysis of key genes and modules during the courses of traumatic brain injury with microarray technology

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