High dose dexmedetomidine as the sole sedative for pediatric MRI

“…Mason et al [13] showed that recovery time from dexmedetomidine sedation was 24.8-35.2 min during MRI scans using loading dose of 2 to 3 μg/kg and the infusion rate increased from 1 to 1.5 to 2 μg/kg/h. In that study, discharge criteria required a minimum Aldrete score of 9 points and in our cases, she presented not fewer than Aldre score of 9 points immediately after radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine for Repeated Sedation in Pediatric Sedation During Consecutive Radiation Therapy

Kim

Baek

Byeon

et al. 2014

J Korean Dent Soc Anesthesiol

View full text Add to dashboard Cite

External beam radiotherapy (EBRT) causes anxiety and claustrophobia in pediatric patients. To provide exact figures and radiation amounts, an appropriate sedation or anesthesia can be supplied. Alpha 2 agonist dexmedetomidine has been used for sedation and anesthesia in pediatric imaging. Dexmedetomidine has an advantage because it has minimal respiratory depression and no direct effects on myocardial function. We report repeated sedation with dexmedetomidine for 33 consecutive radiation therapies in 5 years old children. Dexmedetomidine is a selective α 2 -adrenoreceptor agonist that decreases sympathetic tone and attenuate the stress response to anesthesia and surgery. It was introduced during the 1990s as a sedative in the intensive care unit. Dexmedetomidine has no effect of myocardial function and minimal effect on respiratory function [4,5], these characteristics make an appealing agent for the ERBT in pediatric patients.We present a case about using of dexmedetomidine as the sole sedation anesthetics for 33 consecutive EBRT sessions in a 5 year old child. CASE REPORTA 5 year old female child (111 cm, 21.4 kg) was admitted to hospital with nausea, vomiting and headache that had lasted for 4 weeks. Magnetic resonance imaging (MRI) revealed a contrast enhanced 3.7 × 4.3 cm lesion in left parietal lobe. A glioblastoma was suspected and confirmed histologically after craniotomy with tumor resection. After surgery, 33 consecutive radiation therapies (involved field, two co-axial isocentric field, fractionated; cumulative dose 61.2 Gy) were implemented for duration of 7 weeks. In order to plan proper radiation

show abstract

“…A 16G or 18G intravenous cannula was inserted for drug and continuous fluid infusion. All the patients in group D received injection dexmedetomidine in a dose of 1µg/kg over a period of 10 minutes, [13][14][15] prior to induction of anaesthesia through an infusion pump. During infusion, heart rate, systolic blood pressure, diastolic blood pressure and SPO2 at 5 minutes and at 10 minutes interval (end of infusion) were recorded.…”

Section: Methodsmentioning

confidence: 99%

Dexmedetomidine Attenuates the Stress Response to Laryngoscopy, Endotracheal Intubation and Reduces the Dose of Thiopentone

Munshi¹,

Yunus²,

Khan³

et al. 2015

jemds

View full text Add to dashboard Cite

BACKGROUND: Dexmedetomidine, an α-2 adrenoreceptor agonist, is gaining popularity for its sympatholytic, anaesthetic sparing and haemodynamic stabilizing properties without significant respiratory depression. METHODS: We assessed the efficacy of dexmedetomidine in attenuating stress response to laryngoscopy, endotracheal intubation and analyzed reduction in the dose of thiopentone. Sixty patients scheduled for elective general abdominal surgeries were randomly selected. Control group (C) received isoflurane-opioid-saline and study group (D) received isoflurane-opioid-dexmedetomidine anaesthesia. Dexmedetomidine infusion in a dose of 1 μg/kg and Saline (at same rate-ml/hr.) was given over 10 min before the induction of anaesthesia. All patients were induced with thiopentone, fentanyl and vecuronium. Haemodynamic variables were recorded at different time intervals. RESULTS: The need for thiopentone was decreased by 22.96% in the dexmedetomidine group as compared to the control group. After laryngoscopy and endotracheal intubation, maximal average increase was 8.18% in systolic and 10.07% in diastolic blood pressure in dexmedetomidine group, as compared to 33.81% and 24.02%, respectively, in the control group. Similarly, average increase in heart rate was 7.48% and 19.28% in the dexmedetomidine and control groups, respectively. CONCLUSION: Preoperative infusion of dexmedetomidine is effective in attenuating the stress response to laryngoscopy and endotracheal intubation. It has significant anaesthetic sparing effect.

show abstract

High dose dexmedetomidine as the sole sedative for pediatric MRI

Cited by 293 publications

References 25 publications

Dexmedetomidine in Current Anaesthesia Practice- A Review

Dexmedetomidine in Current Anaesthesia Practice- A Review

Dexmedetomidine for Repeated Sedation in Pediatric Sedation During Consecutive Radiation Therapy

Dexmedetomidine Attenuates the Stress Response to Laryngoscopy, Endotracheal Intubation and Reduces the Dose of Thiopentone

Contact Info

Product

Resources

About