High‐dose cutaneous exposure to mite allergen induces IgG‐mediated protection against anaphylaxis

Hirai, Toshiro; Yoshioka, Yasuo; Takahashi, Hideki; Handa, Takayuki; Izumi, Nastumi; Mori, Takahide; Uemura, Eiichiro; Nishijima, Nobuo; Sagami, Ko‐ichi; Yamaguchi, Manami; Eto, Shun‐ichi; Nagano, Kazuya; Kamada, Haruhiko; Tsunoda, Shin‐ichi; Ishii, Ken J.; Higashisaka, Kazuma; Tsutsumi, Yasuo

doi:10.1111/cea.12722

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…However, allergen specific IgG competes with allergen specific IgE and thereby protects against allergic immune response, a mechanism that is used during allergen-specific immunotherapy[ 33 ]. Indeed, high-dose HDM exposure can induce IgG-mediated protection against HDM-specific anaphylaxis[ 34 ]. Therefore we hypothesize that in our HDM exposed asthma model elevated HDM specific IgG 1 dampens adaptive immunity.…”

Section: Discussionmentioning

confidence: 99%

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

et al. 2017

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C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation.

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Section: Discussionmentioning

confidence: 99%

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

et al. 2017

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“…Recent experimental study using a high-dose cutaneous exposure to Dermatophagoides pteronyssinus mite extract has shown to induce effective blocking IgG production, supporting that the detection of increased IgG antibody titres is a promisor marker of clinical efficacy of AIT [57].…”

Section: Immunotherapy Follow-upmentioning

confidence: 92%

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Taketomi¹,

Miranda²,

Júnior³

et al. 2017

Immunotherapy - Myths, Reality, Ideas, Future

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The clinical efficacy of the allergen-specific immunotherapy (AIT) has been well-documented using inhalant or hymenoptera-derived allergens in atopic patients with corresponding specific IgE antibodies. AIT is considered as the unique treatment that is capable of modifying the natural course of the allergic disease because it induces a variety of immunological mechanisms, with emphasis in the production of blocking IgG antibodies by IL-10-stimulated B cells due to the generation of Treg, Breg, or even Th2 cells. Thus, the measurement of specific IgG subclasses, particularly IgG4, to the crude extract or more importantly to allergen components, might be a useful and potential tool to follow-up objectively the patients undergoing AIT in addition to clinical parameters. In this chapter, the authors have emphasized a very sensitive and highly specific reverse ELISA, developed by them, to measure IgG subclasses directed to clinically relevant natural allergens that are undoubtedly better when compared to those obtained with recombinant counterparts. Such a technique may produce more authentic results taking into account the IgG subclass binding capacity to a particular allergen and might be a valuable and alternative method for monitoring activation of tolerance-inducing mechanisms in patients under AIT.

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“…50,51 Hirai et al employed a mouse model system whereby mice were cutaneously sensitized to Dermatophagoides pteronyssinus dust mite extract (HDM) to examine the relationship of the dosage of cutaneous allergen exposure, development of IgG-and IgE-specific immune responses, and allergen sensitization. 52 The authors showed that epicutaneous exposure of NC/ Nga mice to various doses of HDM induced a dose-dependent exacerbation of atopic dermatitis (AD)-like skin lesions that was associated with elevated HDM-specific IgG and IgE. Notably, the mice exposed to low doses of HDM demonstrated increased susceptibility to HDM-specific IgE and anaphylaxis, and adoptive transfer of total IgG from HDM-sensitized mice reduced the susceptibility seen in mice exposed to low doses of HDM.…”

Section: Allergen-specific Immunotherapy: the Weight Of Iggmentioning

confidence: 99%

Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy

Roberts

Boyle

Crane

et al. 2017

Clin Experimental Allergy

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High‐dose cutaneous exposure to mite allergen induces IgG‐mediated protection against anaphylaxis

Cited by 10 publications

References 41 publications

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy

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