2008
DOI: 10.1159/000151539
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High-Dose Chemotherapy without Stem Cell Transplantation for Refractory Childhood Systemic Lupus Erythematosus

Abstract: Background:Intensive chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is effective for refractory systemic lupus erythematosus (SLE). When intensive chemotherapy is immunoablative but nonmyeloablative, ASCT for hematopoietic reconstitution, with the risk of reinfusing autoreactive lymphocytes, is unnecessary. Methods:Four children aged 12–16 years were enrolled, 3 with WHO class IV nephritis, 2 with hemolytic anemia and 1 with thrombocytopenia. Median disease duration prior to… Show more

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Cited by 7 publications
(6 citation statements)
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“…Carnitine and oxazaphosphorines-induced organs toxicity Cyclophosphamide (CP) and ifosfamide (IFO) are alkylating oxazaphosphorine agents that are commonly used in most cancer chemotherapy and immunosuppressive protocols (Murphy et al, 1986;Preiss and Baumann, 2001). Unfortunately, the optimal clinical usefulness of these drugs is severely limited by a high incidence of urotoxicity, cardiotoxicity and nephrotoxicity (Brock et al, 1982;Colvin, 1999;Ludeman, 1999;Luo et al, 2008). The metabolic pathway of oxazaphosphorines leads to formation of chloroacetyl-CoA, with subsequent depletion of the CoA-SH levels.…”
Section: Carnitine and Carboplatin-induced Bone Marrow Toxicitymentioning
confidence: 99%
“…Carnitine and oxazaphosphorines-induced organs toxicity Cyclophosphamide (CP) and ifosfamide (IFO) are alkylating oxazaphosphorine agents that are commonly used in most cancer chemotherapy and immunosuppressive protocols (Murphy et al, 1986;Preiss and Baumann, 2001). Unfortunately, the optimal clinical usefulness of these drugs is severely limited by a high incidence of urotoxicity, cardiotoxicity and nephrotoxicity (Brock et al, 1982;Colvin, 1999;Ludeman, 1999;Luo et al, 2008). The metabolic pathway of oxazaphosphorines leads to formation of chloroacetyl-CoA, with subsequent depletion of the CoA-SH levels.…”
Section: Carnitine and Carboplatin-induced Bone Marrow Toxicitymentioning
confidence: 99%
“…CP has been in the clinic since the late 1950s and is still one of the most widely used drugs in cancer chemotherapy [1,2]. CP has a wide spectrum of clinical uses and it has been proved to be effective in the treatment of cancer and non-malignant disease states such as rheumatoid arthritis and refractory childhood systemic lupus erythematosus [3,4]. While both CP and ifosfamide have severe urotoxic side effects, only ifosfamide is thought to be nephrotoxic.…”
Section: Introductionmentioning
confidence: 99%
“…Cyclophosphamide (CP) and its structural analogue ifosfamide (IFO), oxazaphosphorine alkylating agents, are highly effective cytotoxic drugs against different types of human tumours and are commonly used in cancer chemotherapy protocols [1][2][3]. While both CP and IFO have severe urotoxic side-effects, only ifosfamide is thought to be nephrotoxic, causing tubular damage and resulting in Fanconi syndrome [4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%